Stratigraphy and Geochemical Characterization of the Middle Triassic - Carnian Sequence of the Lumiei Valley (Carnia, Northeastern Italy)

Stratigraphy of carbonate and terrigenous beds of the Anisian, Ladinian and Carnian of the Lumiei Valley (Middle-Western sector of Carnia, NE Italy) is updated and referred to the new chronological scale of Triassic. Western Carnian Alps were emerged in Early Anisian time. The sea transgressed southward and the region was covered by a thick sequence of lagoonal, clastic, and pelagic sediments. The sequence is thicker in this area, where a system of synsedimentary faults increased the subsidence. Tectonic activity increased during Middle(?) Anisian; this area turned into a topographic and structural high, divided by synsedimentary faults from neighbouring open-marine areas that received large amounts of terrigenous sediments. The latest Anisian and the Ladinian are characterized by a general progradation of the platform facies. Basin areas with pelagic and volcanic sediments were mostly developed in this area and towards the Carnian-Julian Alps. In the Late Ladinian a local resuming of volcanism is present in the transgression marked by the Acquatona Formation. The topmost part of the Ladinian is characterized by the general and wide diffusion of the inner platform, mostly with peritidal facies. At the Ladinian-Carnian boundary, tensional tectonics caused the breaking up of the Schlern platform and increased the subsidence. In the Early-Middle Carnian, this area is dominated by a marine transgression with marly limestone, pelagic, and terrigenous sediments. Moreover, major, minor and trace elements were determined. Statistical multivariate analysis methods were applied to experimental geochemical data to study the stratigraphic sequence. The purpose of this paper was to verify the capacity of these methods to describe the different lithologies of the sequence through its geochemical analysis. A multivariate statistical analysis based on geochemical parameters identifies distinct groups of sediments corresponding to lithological intervals of the examined sequence. In this way a good correspondence between geochemical groups and the lithologies was established

Interactions between species in coastal lagoons: Predation on recent brackish ostracod populations of the Lagoon of Venice (NE Italy).

This chapter analyzes the first evidences of predation observed on recent brackishostracod populations of the Lagoon of Venice. The study of ninety-nine samples andalmost 1300 specimens allowed extraction of 12 bored valves. The bioerosion structures(Oichnus simplex Bromley) are concentrated in the central area of the valves. Boreholediameter shows a negative but not significant correlation with the dimensions of thepredated valves, whereas the number of bored shells is significantly correlated with theostracod density. Predation affects the most abundant species of this environment (mainlyadults and the last juvenile instars)

Geochemistry of natural and anthropogenic fall-out (aerosol and precipitation) collected in NW Mediterranean: two different multivariate statistical approaches

The chemical characteristics of the mineral fractions of aerosol and precipitation collected in Sardinia (NW Mediterranean) are highlighted by means of two multivariate statistical approaches. Two different combinations of classification and statistical methods for geochemical data are presented. It is shown that the application of cluster analysis subsequent to Q-Factor analysis better distinguishes among Saharan dust, Background pollution (Europe-Mediterranean) and Local aerosol from various source regions (Sardinia). Conversely, the application of simple cluster analysis was able to distinguish only between aerosols and precipitation particles, without assigning the sources (local or distant) to the aerosol. This method also highlighted the fact that crust-enriched precipitation is similar to desert-derived aerosol. Major elements (Al, Na) and trace metal (Pb) turn out to be the most discriminating elements of the analysed data set. Independent use of mineralogical, granulometric and meteorological data confirmed the results derived from the statistical methods employed

Association of kidney disease measures with risk of renal function worsening in patients with type 1 diabetes

Background: Albuminuria has been classically considered a marker of kidney damage progression in diabetic patients and it is routinely assessed to monitor kidney function. However, the role of a mild GFR reduction on the development of stage 653 CKD has been less explored in type 1 diabetes mellitus (T1DM) patients. Aim of the present study was to evaluate the prognostic role of kidney disease measures, namely albuminuria and reduced GFR, on the development of stage 653 CKD in a large cohort of patients affected by T1DM. Methods: A total of 4284 patients affected by T1DM followed-up at 76 diabetes centers participating to the Italian Association of Clinical Diabetologists (Associazione Medici Diabetologi, AMD) initiative constitutes the study population. Urinary albumin excretion (ACR) and estimated GFR (eGFR) were retrieved and analyzed. The incidence of stage 653 CKD (eGFR < 60 mL/min/1.73 m2) or eGFR reduction > 30% from baseline was evaluated. Results: The mean estimated GFR was 98 \ub1 17 mL/min/1.73m2 and the proportion of patients with albuminuria was 15.3% (n = 654) at baseline. About 8% (n = 337) of patients developed one of the two renal endpoints during the 4-year follow-up period. Age, albuminuria (micro or macro) and baseline eGFR < 90 ml/min/m2 were independent risk factors for stage 653 CKD and renal function worsening. When compared to patients with eGFR > 90 ml/min/1.73m2 and normoalbuminuria, those with albuminuria at baseline had a 1.69 greater risk of reaching stage 3 CKD, while patients with mild eGFR reduction (i.e. eGFR between 90 and 60 mL/min/1.73 m2) show a 3.81 greater risk that rose to 8.24 for those patients with albuminuria and mild eGFR reduction at baseline. Conclusions: Albuminuria and eGFR reduction represent independent risk factors for incident stage 653 CKD in T1DM patients. The simultaneous occurrence of reduced eGFR and albuminuria have a synergistic effect on renal function worsening

Prevention of congenital malformations and other adverse pregnancy outcomes with 4.0 mg of folic acid : community-based randomized clinical trial in Italy and the Netherlands

Background: In 2010 a Cochrane review confirmed that folic acid (FA) supplementation prevents the first- and second-time occurrence of neural tube defects (NTDs). At present some evidence from observational studies supports the hypothesis that FA supplementation can reduce the risk of all congenital malformations (CMs) or the risk of a specific and selected group of them, namely cardiac defects and oral clefts. Furthermore, the effects on the prevention of prematurity, foetal growth retardation and pre-eclampsia are unclear.Although the most common recommendation is to take 0.4 mg/day, the problem of the most appropriate dose of FA is still open.The aim of this project is to assess the effect a higher dose of peri-conceptional FA supplementation on reducing the occurrence of all CMs. Other aims include the promotion of pre-conceptional counselling, comparing rates of selected CMs, miscarriage, pre-eclampsia, preterm birth, small for gestational age, abruptio placentae.Methods/Design: This project is a joint effort by research groups in Italy and the Netherlands. Women of childbearing age, who intend to become pregnant within 12 months are eligible for the studies. Women are randomly assigned to receive 4 mg of FA (treatment in study) or 0.4 mg of FA (referent treatment) daily. Information on pregnancy outcomes are derived from women-and-physician information.We foresee to analyze the data considering all the adverse outcomes of pregnancy taken together in a global end point (e.g.: CMs, miscarriage, pre-eclampsia, preterm birth, small for gestational age). A total of about 1,000 pregnancies need to be evaluated to detect an absolute reduction of the frequency of 8%. Since the sample size needed for studying outcomes separately is large, this project also promotes an international prospective meta-analysis.Discussion: The rationale of these randomized clinical trials (RCTs) is the hypothesis that a higher intake of FA is related to a higher risk reduction of NTDs, other CMs and other adverse pregnancy outcomes. Our hope is that these trials will act as catalysers, and lead to other large RCTs studying the effects of this supplementation on CMs and other infant and maternal outcomes.Trial registration: Italian trial: ClinicalTrials.gov Identifier: NCT01244347.Dutch trial: Dutch Trial Register ID: NTR3161