Management of severe epistaxis during pregnancy: a case report and review of the literature

Epistaxis is a common problem during pregnancy. Few cases of severe epistaxis, not associated with nasal lesions or clotting disorders, were described in the literature. We reported a case of severe epistaxis in a pregnant patient, exploring all the different possible management options

Investigating the Role of Minimally Invasive Surgery in Patients with Chronic Pulmonary Disease.

In the recent years, the role of minimally invasive surgery (e.g., laparoscopic or robotic assisted surgery) has emerged for the treatments of several benign and malignant conditions [1–4]. Growing..

Wind Energy Forecast in Complex Sites with a Hybrid Neural Network and CFD based Method

Abstract The wind is an intermittent renewable energy source and the energy production forecast is a fundamental activity for many reasons (grid regulation, maintenance, etc.). In this work a hybrid method (based on weather forecast data, neural networks and computational fluid dynamics) and a pure neural network approach are compared in a complex terrain site. The post processing of real production data has been discovered to be a key activity. Treatment and filtering of data spreading out from the supervisory control and data acquisition system are fundamental both for training and testing methods reliability

A Practical Approach in the CFD Simulation of Off-shore Wind Farms through the Actuator Disc Technique

Abstract In this work a practical approach to Computational Fluid Dynamics (CFD) simulations in wind resource evaluation is proposed in a test case of the IEA project (task 31) "Wakebench" focused on the benchmarking of wind wakes models. The proposed method uses an easy wake model, the Actuator Disc (AD), in a CFD approach, in order to understand the wind behavior in a complex wind farm of 18 turbines sited in the northern part of Netherlands, with a sustainable computational load. In order to optimize the simulation results a useful tool that automates the parameters evolution was developed; such tool is able to improve the control of the engineering parameters and is useful to prepare advanced post processing. The study was mainly focused on the analysis of the single wake; also simulations on the double wake case and other tests on larger wind farm were performed with success using the same automatic approach. Results are in quite good agreement with experimental data and the differences between the predicted and experimental results are to be addressed to: global effect of stability, turbine inferences in the actual wind farm and to some lacks in physical wake model

Aquatic ecological modelling with TELEMAC3D: performance of the ecological library AED2 in a natural ecosystem

Hydrodynamic

N-3 polyunsaturated fatty acid effect in periodontal disease: state of art and possible mechanisms involved.

Anti-inflammatory properties have been widely reported for n-3 polyunsaturated fatty acids (PUFAs) and some studies have been focalized on their possible role in the modulation of gingivitis and alveolar bone resorption in periodontal disease (PD). Increased formation of arachidonic acid-derived inflammatory eicosanoids and augmented oxidative stress are two molecular mechanisms pathogenetically involved in the progression of PD and known to be inhibited by n-3 PUFAs in PD setting. The present review will focus also on other molecular pathways and factors known to be altered in the development of PD and known to be subject to n-3 PUFA modulation in other pathological settings different from PD. Overall, the available findings strongly encourage further experimental studies on animals subject to experimental PD and treated with n-3 PUFAs, long term n-3 PUFA intervention studies on PD patients and molecular studies to identify additional potential molecular routes of n-3 PUFA action in PD

On the Possible Wind Energy Contribution for Feeding a High Altitude Smart Mini Grid

The use of renewable energy sources to increase electricity access, especially in remote areas as high mountains, is a possible contribution to poverty reduction, climate change mitigation and improved resilience. In this paper an evaluation of the wind potential of a remote area in Nepal is performed, using CFD methods and the simulation of a micro wind turbine projected by Perugia University. With an accurate analysis of wind data and air density effects it is possible to test energy production potential in areas with high average wind speed. The overall estimated production for each turbine is an interesting result and an easily exportable contribution to the perspective of sustainable development at very high altitudes and remote areas

The Anesthesiologist's Perspective Regarding Non-intubated Thoracic Surgery: A Scoping Review

Non-intubated thoracic surgery (NITS) is a growing practice, alongside minimally invasive thoracic surgery. To date, only a consensus of experts provided opinions on NITS leaving a number of questions unresolved. We then conducted a scoping review to clarify the state of the art regarding NITS. The systematic review of all randomized and non-randomized clinical trials dealing with NITS, based on Pubmed, EMBASE, and Scopus, retrieved 665 articles. After the exclusion of ineligible studies, 53 were assessed examining: study type, Country of origin, surgical procedure, age, body mass index, American Society of Anesthesiologist's physical status, airway management device, conversion to orotracheal intubation and pulmonary complications rates and length of hospital stay. It emerged that NITS is a procedure performed predominantly in Asia, and certain European Countries. In China, NITS is more frequently performed for parenchymal resection surgery, whereas in Europe, it is mainly employed for pleural pathologies. The most commonly used device for airway management is the laryngeal mask. The conversion rate to orotracheal intubation is a~3%. The results of the scoping review seem to suggest that NITS procedures are becoming increasingly popular, but its role needs to be better defined. Further randomized clinical trials are needed to better define the role of the clinical variables possibly impacting on the technique effectiveness. SYSTEMATIC REVIEW REGISTRATION: https://osf.io/mfvp3/, identifier: 10.17605/OSF.IO/MFVP3

Match-Making Reactors to Chemistry: A Continuous Manufacturing-Enabled Sequence to a Key Benzoxazole Pharmaceutical Intermediate

The focus of this study was to develop a chemical reaction sequence toward a key benzoxazole building block, required for clinical manufacturing of a lead candidate in the respiratory disease area. The chemistry consisted of initial low-temperature reactions with an organometallic reagent to generate the benzoxazole core, and was followed by noncryogenic transformations toward a sulfonamide substituent. With particular interest in continuous-flow manufacturing we attempted to integrate the entire sequence on lab scale. Subsequent in-depth process research, supported by PAT and calorimetry studies, revealed the critical parameters of each step, leading to a more rational attribution of mode of operation: flow, batch, or semibatch. Two bench-scale cascades of continuously stirred tank reactors (CSTRs) were constructed to meet the challenge of high exothermicity and solids formation and were key to smoothly upscaling the chemistry to deliver 17 kg of benzoxazole in superior yield, quality, and robustness

Telemac3D for aquatic ecological modelling: calibration of the coupled ecological library AED2

HydrodynamicsAbstrac