Mucus-degrading Bacteroides link carbapenems to aggravated graft-versus-host disease

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Cyclostratigraphy - concepts, definitions, and applications

Cyclostratigraphy is the subdiscipline of stratigraphy that deals with the identification, characterization, correlation, and interpretation of cyclic variations in the stratigraphic record and, in particular, with their application in geochronology by improving the accuracy and resolution of time-stratigraphic frameworks. As such it uses astronomical cycles of known periodicities to date and interpret the sedimentary record. The most important of these cycles are the Earth's orbital cycles of precession, obliquity, and eccentricity (Milankovitch cycles), which result from perturbations of the Earth's orbit and its rotational axis. They have periods ranging from 20 to 400 kyr, and even up to millions of years. These cycles translate (via orbital-induced changes in insolation) into climatic, oceanographic, sedimentary, and biological changes that are potentially recorded in the sedimentary archives through geologic time. Many case studies have demonstrated that detailed analysis of the sedimentary record (stacking patterns of beds, disconformities, facies changes, fluctuations in biological composition, and/or changes in geochemical composition) enables identification of these cycles with high confidence. Once the relationship between the sedimentary record and the orbital forcing is established, an unprecedented high time resolution becomes available, providing a precise and accurate framework for the timing of Earth system processes. For the younger part of the geologic past, astronomical time scales have been constructed by tuning cyclic palaeoclimatic records to orbital and insolation target curves; these time scales are directly tied to the Present. In addition, the astronomical tuning has been used to calibrate the ⁴⁰Ar/³⁹Ar dating method. In the older geologic past, "floating" astronomical time scales provide a high time resolution for stratigraphic intervals, even if their radiometric age is subject to the error margins of the dating techniques

Conodont distribution, paleoecology, and preliminary biostratigraphy of the Upper Cherokee and Marmaton groups (Upper Desmoinesian, Middle Pennsylvanian) from two cores in south-central Iowa

https://ir.uiowa.edu/igs_tis/1013/thumbnail.jp

Genomic innovations, transcriptional plasticity and gene loss underlying the evolution and divergence of two highly polyphagous and invasive Helicoverpa pest species

Background: Helicoverpa armigera and Helicoverpa zea are major caterpillar pests of Old and New World agriculture, respectively. Both, particularly H. armigera, are extremely polyphagous, and H. armigera has developed resistance to many insecticides. Here we use comparative genomics, transcriptomics and resequencing to elucidate the genetic basis for their properties as pests. Results: We find that, prior to their divergence about 1.5 Mya, the H. armigera/H. zea lineage had accumulated up to more than 100 more members of specific detoxification and digestion gene families and more than 100 extra gustatory receptor genes, compared to other lepidopterans with narrower host ranges. The two genomes remain very similar in gene content and order, but H. armigera is more polymorphic overall, and H. zea has lost several detoxification genes, as well as about 50 gustatory receptor genes. It also lacks certain genes and alleles conferring insecticide resistance found in H. armigera. Non-synonymous sites in the expanded gene families above are rapidly diverging, both between paralogues and between orthologues in the two species. Whole genome transcriptomic analyses of H. armigera larvae show widely divergent responses to different host plants, including responses among many of the duplicated detoxification and digestion genes. Conclusions: The extreme polyphagy of the two heliothines is associated with extensive amplification and neofunctionalisation of genes involved in host finding and use, coupled with versatile transcriptional responses on different hosts. H. armigera's invasion of the Americas in recent years means that hybridisation could generate populations that are both locally adapted and insecticide resistant