525 research outputs found
Realistic loophole-free Bell test with atom-photon entanglement
The establishment of nonlocal correlations, obtained through the violation of
a Bell inequality, is not only important from a fundamental point of view, but
constitutes the basis for device-independent quantum information technologies.
Although several nonlocality tests have been performed so far, all of them
suffered from either the locality or the detection loopholes. Recent studies
have suggested that the use of atom-photon entanglement can lead to Bell
inequality violations with moderate transmission and detection efficiencies. In
this paper we propose an experimental setup realizing a simple atom-photon
entangled state that, under realistic experimental parameters available to
date, achieves a significant violation of the Clauser-Horn-Shimony-Holt
inequality. Most importantly, the violation remains when considering typical
detection efficiencies and losses due to required propagation distances.Comment: 21 pages, 5 figures, 3 table, to appear in Nature Com
Drug Sensitivity Testing in Cytoreductive Surgery and Intraperitoneal Chemotherapy of Pseudomyxoma Peritonei
Long-term aspirin use and colorectal cancer risk: a cohort study in Sweden
In a prospective cohort study of 74 250 Swedish women and men, with 7.2 years of follow-up and 705 incident colorectal cancer cases, long duration of aspirin use (>20 years) was associated with a reduced risk of colorectal cancer (multivariate rate ratio: 0.65; 95% confidence interval: 0.45–0.94). Aspirin use for a shorter period was not associated with risk
A Novel Animal Model of Borrelia recurrentis Louse-Borne Relapsing Fever Borreliosis Using Immunodeficient Mice
Louse-borne relapsing fever (LBRF) borreliosis is caused by Borrelia recurrentis, and it is a deadly although treatable disease that is endemic in the Horn of Africa but has epidemic potential. Research on LBRF has been severely hampered because successful infection with B. recurrentis has been achieved only in primates (i.e., not in other laboratory or domestic animals). Here, we present the first non-primate animal model of LBRF, using SCID (-B, -T cells) and SCID BEIGE (-B, -T, -NK cells) immunocompromised mice. These animals were infected with B. recurrentis A11 or A17, or with B. duttonii 1120K3 as controls. B. recurrentis caused a relatively mild but persistent infection in SCID and SCID BEIGE mice, but did not proliferate in NUDE (-T) and BALB/c (wild-type) mice. B. duttonii was infectious but not lethal in all animals. These findings demonstrate that the immune response can limit relapsing fever even in the absence of humoral defense mechanisms. To study the significance of phagocytic cells in this context, we induced systemic depletion of such cells in the experimental mice by injecting them with clodronate liposomes, which resulted in uncontrolled B. duttonii growth and a one-hundred-fold increase in B. recurrentis titers in blood. This observation highlights the role of macrophages and other phagocytes in controlling relapsing fever infection. B. recurrentis evolved from B. duttonii to become a primate-specific pathogen that has lost the ability to infect immunocompetent rodents, probably through genetic degeneration. Here, we describe a novel animal model of B. recurrentis based on B- and T-cell-deficient mice, which we believe will be very valuable in future research on LBRF. Our study also reveals the importance of B-cells and phagocytes in controlling relapsing fever infection
Renormalizing a BRST-invariant composite operator of mass dimension 2 in Yang-Mills theory
We discuss the renormalization of a BRST and anti-BRST invariant composite
operator of mass dimension 2 in Yang-Mills theory with the general BRST and
anti-BRST invariant gauge fixing term of the Lorentz type. The interest of this
study stems from a recent claim that the non-vanishing vacuum condensate of the
composite operator in question can be an origin of mass gap and quark
confinement in any manifestly covariant gauge, as proposed by one of the
authors. First, we obtain the renormalization group flow of the Yang-Mills
theory. Next, we show the multiplicative renormalizability of the composite
operator and that the BRST and anti-BRST invariance of the bare composite
operator is preserved under the renormalization. Third, we perform the operator
product expansion of the gluon and ghost propagators and obtain the Wilson
coefficient corresponding to the vacuum condensate of mass dimension 2.
Finally, we discuss the connection of this work with the previous works and
argue the physical implications of the obtained results.Comment: 49 pages, 35 eps-files, A number of typographic errors are corrected.
A paragraph is added in the beginning of section 5.3. Two equations (7.1) and
(7.2) are added. A version to be published in Phys. Rev.
Evidence that autonomic mechanisms contribute to the adaptive increase in insulin secretion during dexamethasone-induced insulin resistance in humans
Testing foundations of quantum mechanics with photons
The foundational ideas of quantum mechanics continue to give rise to
counterintuitive theories and physical effects that are in conflict with a
classical description of Nature. Experiments with light at the single photon
level have historically been at the forefront of tests of fundamental quantum
theory and new developments in photonics engineering continue to enable new
experiments. Here we review recent photonic experiments to test two
foundational themes in quantum mechanics: wave-particle duality, central to
recent complementarity and delayed-choice experiments; and Bell nonlocality
where recent theoretical and technological advances have allowed all
controversial loopholes to be separately addressed in different photonics
experiments.Comment: 10 pages, 5 figures, published as a Nature Physics Insight review
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Evaluation of the global lung function initiative 2012 reference values for spirometry in a Swedish population sample
Background: The Global Lung Function Initiative 2012 (GLI) reference values are currently endorsed by several respiratory societies but evaluations of applicability for adults resident in European countries are lacking. The aim of this study was to evaluate if the GLI reference values are appropriate for an adult Caucasian Swedish population. Methods: During 2008-2013, clinical examinations including spirometry were performed on general population samples in northern Sweden, in which 501 healthy Caucasian non-smokers were identified. Predicted GLI reference values and Z-scores were calculated for each healthy non-smoking subject and the distributions and mean values for FEV1, FVC and the FEV1/FVC ratio were examined. The prevalence of airway obstruction among these healthy non-smokers was calculated based on the Lower Limit of normal (LLN) criterion (lower fifth percentile) for the FEV1/FVC ratio. Thus, by definition, a prevalence of 5% was expected. Results: The Z-scores for FEV1, FVC and FEV1/FVC were reasonably, although not perfectly, normally distributed, but not centred on zero. Both predicted FEV1 and, in particular, FVC were lower compared to the observed values in the sample. The deviations were greater among women compared to men. The prevalence of airway obstruction based on the LLN criterion for the FEV1/FVC ratio was 9.4% among women and 2.7% among men. Conclusions: The use of the GLI reference values may produce biased prevalence estimates of airway obstruction in Sweden, especially among women. These results demonstrate the importance of validating the GLI reference values in different countries.Peer reviewe
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