91 research outputs found
Volume modulus inflation and a low scale of SUSY breaking
The relation between the Hubble constant and the scale of supersymmetry
breaking is investigated in models of inflation dominated by a string modulus.
Usually in this kind of models the gravitino mass is of the same order of
magnitude as the Hubble constant which is not desirable from the
phenomenological point of view. It is shown that slow-roll saddle point
inflation may be compatible with a low scale of supersymmetry breaking only if
some corrections to the lowest order Kahler potential are taken into account.
However, choosing an appropriate Kahler potential is not enough. There are also
conditions for the superpotential, and e.g. the popular racetrack
superpotential turns out to be not suitable. A model is proposed in which
slow-roll inflation and a light gravitino are compatible. It is based on a
superpotential with a triple gaugino condensation and the Kahler potential with
the leading string corrections. The problem of fine tuning and experimental
constraints are discussed for that model.Comment: 28 pages, 8 figures, comments and references added, minor change in
notation, version to be publishe
Flavour in supersymmetry: horizontal symmetries or wave function renormalisation
We compare theoretical and experimental predictions of two main classes of
models addressing fermion mass hierarchies and flavour changing neutral
currents (FCNC) effects in supersymmetry: Froggatt-Nielsen (FN) U(1) gauged
flavour models and Nelson-Strassler/extra dimensional models with hierarchical
wave functions for the families. We show that whereas the two lead to identical
predictions in the fermion mass matrices, the second class generates a stronger
suppression of FCNC effects. We prove that, whereas at first sight the FN setup
is more constrained due to anomaly cancelation conditions, imposing unification
of gauge couplings in the second setup generates conditions which precisely
match the mixed anomaly constraints in the FN setup. Finally, we provide an
economical extra dimensional realisation of the hierarchical wave functions
scenario in which the leptonic FCNC can be efficiently suppressed due to the
strong coupling (CFT) origin of the electron mass.Comment: 23 page
Lectures on Cosmic Inflation and its Potential Stringy Realizations
These notes present a brief introduction to Hot Big Bang cosmology and Cosmic
Inflation, together with a selection of some recent attempts to embed inflation
into string theory. They provide a partial description of lectures presented in
courses at Dubrovnik in August 2006, at CERN in January 2007 and at Cargese in
August 2007. They are aimed at graduate students with a working knowledge of
quantum field theory, but who are unfamiliar with the details of cosmology or
of string theory.Comment: 68 pages, lectures given at Dubrovnik, Aug 2006; CERN, January 2007;
and Cargese, Aug 200
Accidental Inflation in String Theory
We show that inflation in type IIB string theory driven by the volume modulus
can be realized in the context of the racetrack-based Kallosh-Linde model (KL)
of moduli stabilization. Inflation here arises through the volume modulus
slow-rolling down from a flat hill-top or inflection point of the scalar
potential. This situation can be quite generic in the landscape, where by
uplifting one of the two adjacent minima one can turn the barrier either to a
flat saddle point or to an inflection point supporting eternal inflation. The
resulting spectral index is tunable in the range of 0.93 < n_s < 1, and there
is only negligible production of primordial gravitational waves r < 10^{-6}.
The flatness of the potential in this scenario requires fine-tuning, which may
be justified taking into account the exponential reward by volume factors
preferring the regions of the universe with the maximal amount of slow-roll
inflation. This consideration leads to a tentative prediction of the spectral
index or depending on whether the
potential has a symmetry phi -> - phi or not.Comment: 15 pages, 6 figures, LaTeX, uses RevTex
Chiral matter wavefunctions in warped compactifications
We analyze the wavefunctions for open strings stretching between intersecting
7-branes in type IIB/F-theory warped compactifications, as a first step in
understanding the warped effective field theory of 4d chiral fermions. While in
general the equations of motion do not seem to admit a simple analytic
solution, we provide a method for solving the wavefunctions in the case of weak
warping. The method describes warped zero modes as a perturbative expansion in
the unwarped spectrum, the coefficients of the expansion depending on the
warping. We perform our analysis with and without the presence of worldvolume
fluxes, illustrating the procedure with some examples. Finally, we comment on
the warped effective field theory for the modes at the intersection.Comment: 64 pages, 1 figure. References updated, typos fixed, discussion on
varying dilaton case slightly modified. Version to appear in JHE
Models of Modular Inflation and Their Phenomenological Consequences
We study models of modular inflation of the form expected to arise from low
energy effective actions of superstring theories. We argue on general grounds
that the most likely models of modular slow-roll inflation are small field
models in which the inflaton moves about a Planck distance from an extremum of
the potential. We then focus on models in which the inflaton is the bosonic
component of a single (complex) chiral superfield and explain the generic
difficulties in designing small field models of modular inflation. We then show
that if the Kaehler potential (KP) of the inflaton is logarithmic as in
perturbative string theories, then it is not possible to satisfy the slow-roll
conditions for any superpotential. We find that if the corrections to the KP
are large enough so it can be approximated by a canonical KP in the vicinity of
the extremum, then viable slow-roll inflation is possible. In this case,
several parameters have to be tuned to a fraction of a percent. We give a
prescription for designing successful small field supergravity models of
inflation when the KP is canonical and calculate the slow-roll parameters from
the superpotential parameters. Our results strengthen the case for models in
which the moduli slowly roll about a Planck distance from a relatively high
scale extremum that is located in the vicinity of the central region of moduli
space units. Generic models of this class predict a red spectrum of scalar
perturbations and negligible spectral index running. They also predict a
characteristic suppression of tensor perturbations despite the high scale of
inflation. Consequently, a detection of primordial tensor anisotropies or
spectral index running in cosmic microwave background observations in the
foreseeable future will rule out this entire class of modular inflation models.Comment: 35 pages, 1 figur
Manipulation of Cell:Cell Contacts and Mesoderm Suppressing Activity Direct Lineage Choice from Pluripotent Primitive Ectoderm-Like Cells in Culture
In the mammal, the pluripotent cells of embryo differentiate and commit to either the mesoderm/endoderm lineages or the ectoderm lineage during gastrulation. In culture, the ability to direct lineage choice from pluripotent cells into the mesoderm/endoderm or ectoderm lineages will enable the development of technologies for the formation of highly enriched or homogenous populations of cells. Here we show that manipulation of cell:cell contact and a mesoderm suppressing activity in culture affects the outcome of pluripotent cell differentiation and when both variables are manipulated appropriately they can direct differentiation to either the mesoderm or ectoderm lineage. The disruption of cell:cell contacts and removal of a mesoderm suppressor activity results in the differentiation of pluripotent, primitive ectoderm-like cells to the mesoderm lineage, while maintenance of cell:cell contacts and inclusion, within the culture medium, of a mesoderm suppressing activity results in the formation of near homogenous populations of ectoderm. Understanding the contribution of these variables in lineage choice provides a framework for the development of directed differentiation protocols that result in the formation of specific cell populations from pluripotent cells in culture
Snake Cathelicidin from Bungarus fasciatus Is a Potent Peptide Antibiotics
Background: Cathelicidins are a family of antimicrobial peptides acting as multifunctional effector molecules of innate immunity, which are firstly found in mammalians. Recently, several cathelicidins have also been found from chickens and fishes. No cathelicidins from other non-mammalian vertebrates have been reported. Principal Findings: In this work, a cathelicidin-like antimicrobial peptide named cathelicidin-BF has been purified from the snake venoms of Bungarus fasciatus and its cDNA sequence was cloned from the cDNA library, which confirm the presence of cathelicidin in reptiles. As other cathelicidins, the precursor of cathelicidin-BF has cathelin-like domain at the N terminus and carry the mature cathelicidin-BF at the C terminus, but it has an atypical acidic fragment insertion between the cathelin-like domain and the C-terminus. The acidic fragment is similar to acidic domains of amphibian antimicrobial precursors. Phylogenetic analysis revealed that the snake cathelicidin had the nearest evolution relationship with platypus cathelicidin. The secondary structure of cathelicidin-BF investigated by CD and NMR spectroscopy in the presence of the helicogenic solvent TFE is an amphipathic α-helical conformation as many other cathelicidins. The antimicrobial activities of cathelicidin BF against forty strains of microorganisms were tested. Cathelicidin-BF efficiently killed bacteria and some fungal species including clinically isolated drug-resistance microorganisms. It was especially active against Gram-negative bacteria. Furthermore, it could exert antimicrobial activity against some saprophytic fungus. No hemolytic and cytotoxic activity was observed at the dose of up to 400 µg/ml. Cathelicidin-BF could exist stably in the mice plasma for at least 2.5 hours. Conclusion: Discovery of snake cathelicidin with atypical structural and functional characterization offers new insights on the evolution of cathelicidins. Potent, broad spectrum, salt-independent antimicrobial activities make cathelicidin-BF an excellent candidate for clinical or agricultural antibiotics
Genomic Targets of Brachyury (T) in Differentiating Mouse Embryonic Stem Cells
The T-box transcription factor Brachyury (T) is essential for formation of the posterior mesoderm and the notochord in vertebrate embryos. Work in the frog and the zebrafish has identified some direct genomic targets of Brachyury, but little is known about Brachyury targets in the mouse.Here we use chromatin immunoprecipitation and mouse promoter microarrays to identify targets of Brachyury in embryoid bodies formed from differentiating mouse ES cells. The targets we identify are enriched for sequence-specific DNA binding proteins and include components of signal transduction pathways that direct cell fate in the primitive streak and tailbud of the early embryo. Expression of some of these targets, such as Axin2, Fgf8 and Wnt3a, is down regulated in Brachyury mutant embryos and we demonstrate that they are also Brachyury targets in the human. Surprisingly, we do not observe enrichment of the canonical T-domain DNA binding sequence 5'-TCACACCT-3' in the vicinity of most Brachyury target genes. Rather, we have identified an (AC)(n) repeat sequence, which is conserved in the rat but not in human, zebrafish or Xenopus. We do not understand the significance of this sequence, but speculate that it enhances transcription factor binding in the regulatory regions of Brachyury target genes in rodents.Our work identifies the genomic targets of a key regulator of mesoderm formation in the early mouse embryo, thereby providing insights into the Brachyury-driven genetic regulatory network and allowing us to compare the function of Brachyury in different species
From Dynamic Expression Patterns to Boundary Formation in the Presomitic Mesoderm
The segmentation of the vertebrate body is laid down during early embryogenesis. The formation of signaling gradients, the periodic expression of genes of the Notch-, Fgf- and Wnt-pathways and their interplay in the unsegmented presomitic mesoderm (PSM) precedes the rhythmic budding of nascent somites at its anterior end, which later develops into epithelialized structures, the somites. Although many in silico models describing partial aspects of somitogenesis already exist, simulations of a complete causal chain from gene expression in the growth zone via the interaction of multiple cells to segmentation are rare. Here, we present an enhanced gene regulatory network (GRN) for mice in a simulation program that models the growing PSM by many virtual cells and integrates WNT3A and FGF8 gradient formation, periodic gene expression and Delta/Notch signaling. Assuming Hes7 as core of the somitogenesis clock and LFNG as modulator, we postulate a negative feedback of HES7 on Dll1 leading to an oscillating Dll1 expression as seen in vivo. Furthermore, we are able to simulate the experimentally observed wave of activated NOTCH (NICD) as a result of the interactions in the GRN. We esteem our model as robust for a wide range of parameter values with the Hes7 mRNA and protein decays exerting a strong influence on the core oscillator. Moreover, our model predicts interference between Hes1 and HES7 oscillators when their intrinsic frequencies differ. In conclusion, we have built a comprehensive model of somitogenesis with HES7 as core oscillator that is able to reproduce many experimentally observed data in mice
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