13 research outputs found

    Emerging evidence of a link between the polycystins and the mTOR pathways

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    Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disease characterized by the formation of renal cysts. This disease can be caused by mutations in two genes, PKD1 and PKD2, which encode polycystin-1 (PC-1) and -2 (PC-2), respectively

    Thick ascending limb: the Na+:K+:2Cl− co-transporter, NKCC2, and the calcium-sensing receptor, CaSR

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    Translational research in ADPKD: lessons from animal models

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    Mechanisms of disease, diagnostics and therap

    Physiology and pathophysiology of SLC12A1/2 transporters

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