Warmte-koude opslag en duurzaam gebruik van de ondergrond

Warmte koude opslag (WKO) is een energie en kostenbesparende methode voor het verwarmen en koelen van gebouwen. Open WKO systemen pompen het grondwater heen en weer om het gebouw te koelen of te verwarmen. Gesloten WKO systemen gebruiken alleen de warmte van het grondwater om huizen te verwarmen of te koelen. In Nederland is er de laatste jaren een sterke en door de overheid gestimuleerde groei van het aantal WKO systemen. Gesloten WKO systemen zouden een risico kunnen vormen voor de kwaliteit van het grondwater door het groot aantal perforaties van de ondergrond en door het mogelijke lekken van koelvloeistof. Bij open WKO systemen moet voorkomen worden dat verschillende grondwaterlagen gemengd worden waardoor ongewenste geochemische en microbiologische processen optreden. In principe kan een open WKO systeem wel op een vervuilde locatie worden toegepast, maar er is specifiek maatwerk nodig om de verspreiding van de vervuiling te beperken. De bescheiden temperatuursveranderingen die door WKO systemen worden opgewekt in het grondwater vormen slechts een gering risico voor geochemische processen. Deze temperatuursveranderingen zouden in principe wel aanleiding kunnen geven tot een toename van het aantal ziektekiemen in het grondwater. Daarom is het belangrijk dat er voldoende afstand is tussen een drinkwaterwinning en de omringende WKO installaties. Verder onderzoek is nodig om vast te stellen welke invloed WKO installaties hebben op de bacteriën in het grondwater. Het opslaan van heet (90 °C) grondwater heeft een groot aantal milieubezwaren. De Europese kaderrichtlijn water ziet ook de inbreng van warmte in het grondwater als een mogelijke verontreiniging wanneer daar nadelige gevolgen voor mensen of ecosystemen aan verbonden zijn. Het toezicht van de provincies op het groeiende aantal WKO systemen in de praktijk verdient nadere aandacht

Combining prior knowledge with data driven modeling of a batch distillation column including start-up

This paper presents the development of a simple model which describes the product quality and production over time of an experimental batch distillation column, including start-up. The model structure is based on a simple physical framework, which is augmented with fuzzy logic. This provides a way to use prior knowledge about the dynamics, which have a general validity, while additional information about the specific column behavior is derived from measured process data. The model framework is applicable for a wide range of columns operating under a certain control policy. The model framework for the particular column under study makes a priori assumptions about the specific behavior superfluous. In addition, a detailed description of the internal dynamics is not required, which reduces modeling effort. Three different hybrid model structures are compared; the model that uses the available sources of information most effectively can be used to simulate production including part of the start-up by applying constant quality control. (C) 2003 Elsevier Science Ltd. All rights reserved

Glutamine-enriched enteral nutrition in very low birth weight infants. Design of a double-blind randomised controlled trial [ISRCTN73254583]

BACKGROUND: Enteral feeding of very low birth weight (VLBW) infants is a challenge, since metabolic demands are high and administration of enteral nutrition is limited by immaturity of the gastrointestinal tract. The amino acid glutamine plays an important role in maintaining functional integrity of the gut. In addition, glutamine is utilised at a high rate by cells of the immune system. In critically ill patients, glutamine is considered a conditionally essential amino acid. VLBW infants may be especially susceptible to glutamine depletion as nutritional supply of glutamine is limited in the first weeks after birth. Glutamine depletion has negative effects on functional integrity of the gut and leads to immunosuppression. This double-blind randomised controlled trial is designed to investigate the effect of glutamine-enriched enteral nutrition on feeding tolerance, infectious morbidity and short-term outcome in VLBW infants. Furthermore, an attempt is made to elucidate the role of glutamine in postnatal adaptation of the gut and modulation of the immune response. METHODS: VLBW infants (gestational age <32 weeks and/or birth weight <1500 g) are randomly allocated to receive enteral glutamine supplementation (0.3 g/kg/day) or isonitrogenous placebo supplementation between day 3 and 30 of life. Primary outcome is time to full enteral feeding (defined as a feeding volume ≥ 120 mL/kg/day). Furthermore, incidence of serious infections and short-term outcome are evaluated. The effect of glutamine on postnatal adaptation of the gut is investigated by measuring intestinal permeability and determining faecal microflora. The role of glutamine in modulation of the immune response is investigated by determining plasma Th1/Th2 cytokine concentrations following in vitro whole blood stimulation

NF-κB dependent and independent mechanisms of quartz-induced proinflammatory activation of lung epithelial cells

In the initiation and progression of pulmonary inflammation, macrophages have classically been considered as a crucial cell type. However, evidence for the role of epithelial type II cells in pulmonary inflammation has been accumulating. In the current study, a combined in vivo and in vitro approach has been employed to investigate the mechanisms of quartz-induced proinflammatory activation of lung epithelial cells. In vivo, enhanced expression of the inflammation- and oxidative stress-related genes HO-1 and iNOS was found on the mRNA level in rat lungs after instillation with DQ12 respirable quartz. Activation of the classical NF-κB pathway in macrophages and type II pneumocytes was indicated by enhanced immunostaining of phospho-IκBα in these specific lung cell types. In vitro, the direct, particle-mediated effect on proinflammatory signalling in a rat lung epithelial (RLE) cell line was compared to the indirect, macrophage product-mediated effect. Treatment with quartz particles induced HO-1 and COX-2 mRNA expression in RLE cells in an NF-κB independent manner. Supernatant from quartz-treated macrophages rapidly activated the NF-κB signalling pathway in RLE cells and markedly induced iNOS mRNA expression up to 2000-fold compared to non-treated control cells. Neutralisation of TNFα and IL-1β in macrophage supernatant did not reduce its ability to elicit NF-κB activation of RLE cells. In addition the effect was not modified by depletion or supplementation of intracellular glutathione

A Unifying View on Recombination Spaces and Abstract Convex Evolutionary Search

This is the author accepted manuscript. The final version is available from Springer via the DOI in this record.Proceedings of EvoCOP 2019 - 19th European Conference on Evolutionary Computation, 24-26 April 2019, Leipzig, GermanyPrevious work proposed to unify an algebraic theory of fitness landscapes and a geometric framework of evolutionary algorithms (EAs). One of the main goals behind this unification is to develop an analytical method that verifies if a problem's landscape belongs to certain abstract convex landscapes classes, where certain recombination-based EAs (without mutation) have polynomial runtime performance. This paper advances such unification by showing that: (a) crossovers can be formally classified according to geometric or algebraic axiomatic properties; and (b) the population behaviour induced by certain crossovers in recombination-based EAs can be formalised in the geometric and algebraic theories. These results make a significant contribution to the basis of an integrated geometric-algebraic framework with which analyse recombination spaces and recombination-based EAs