The conservation project in polarity of the multidimensional survey. The need for critical discussion drafting of operating protocols. Modernity and tradition: the wooden caisson in the great hall of the Economic School in Naples

The paper focuses on the multidisciplinary study of the coffered ceiling wooden, existing in the Great Hall of the School of Economics of Naples. One of the rare examples of wooden work carried out in Italy in the twentieth century, designed by Roberto Pane, master of Italian architecture and academia.. The multidisciplinary and multidimensional approach has involved researchers and academics active in remote sensing and 3D modeling (Argenziano P.), in the conservation and restoration (Saverio Carillo, Petillo Pasquale, Luca Ferri), in lighting and colorimetry (Sibilio Sergio, Falconetti Pasquale).. The direct and instrumental survey, from 3D modeling to videoendoscopy, from the characterization of materials and coatings, the work has allowed us to understand the material composition of the coffered ceiling and its manufacturing technology in a non-invasive approach. This protocol will be useful for a possible conservation work of the coffered ceiling in question and also provides a scientific protocol for the analytical study of coffered wood of any size and timing

La Resurrezione by Pericle Fazzini in the Aula Paolo VI at the Vatican. The restoration of contemporary art by sacred multi-disciplinary dimensions

The preservative restoration of the great work of Pericle Fazzini (1913-1987), entitled La Resurrezione in the Aula Paolo VI at the Vatican, has involved the workers of the Fonderia Del Giudice (Nola), and (for free) the authors of this paper, as researchers of the Faculty Architecture “Luigi Vanvitelli” and of the Benecon Research Center, for over seventy days.. The University contribution was orientated towards the scientific project of its conservation and restoration, as well as providing a repertoire of diagnostic tests that have supported the intervention protocol, appropriately designed, applied by the Foundry and confirmed by the Directorate of the Vatican Museums and Laboratories.. The essays describe the multidisciplinary methodology, analytical operations as well as techniques that have marked all the development and implementation phases of the preservative restoration, from concept to project, from shipyard to communication. At the same time, particular attention was given to the spectacular architectural space designed by Pier Luigi Nervi.. In line with the Tenth Forum topics, the work was inspired by the minimal intervention – remote analysis and non-invasive interventions – accurately planned, for the best expected result, that has returned the dazzling image to the statue as Pericle Fazzini has realized in a mixed alloy of bronze and brass. The work has also provided material and structural integrity of the articulated metallic mass

Enhanced in vitro antitumor activity of a titanocene complex encapsulated into polycaprolactone (PCL) electrospun fibers

The purpose of this work was to achieve detailed biomaterials characterization of a drug delivery system for local cancer treatment based on electrospun titanocene trichloride-​loaded resorbable polycaprolactone (PCL) fibers. METHODS: The PCL fibers were characterized for their structural, morphologic and physical properties. The drug release kinetics of the titanocene complex was investigated at different concentrations, to obtain a set of correlations between structure and tuneable release. After exposing cancer cells directly onto the surface of PCL fibers, the anti-​proliferative effects of titanocene-​loaded PCL were assessed by: (i) counting viable cells via live​/dead staining methods, and (ii) analyzing cell apoptosis. Titanocene concentration influenced fiber diameters reduced for PCL filled with titanocene. X-​ray analysis suggested that the titanocene, encapsulated into the PCL fibers, is not allowed to crystallize and exists as amorphous aggregates into the fibers. The titanocene release curves presented two stages unrelated to PCL degradation: an initial burst release followed by a release linear with time, extending for a very long time. All of the titanocene-​loaded fibers revealed sustained drug release properties suggesting their potential clinical applicability for the treatment of local cancer diseases

Rabeprazole is equivalent to omeprazole in the treatment of erosive gastro-oesophageal reflux disease. A randomised, double-blind, comparative study of rabeprazole and omeprazole 20 mg in acute treatment of reflux oesophagitis, followed by a maintenance open-label, low-dose therapy with rabeprazole

Background.: Previous studies have shown similar effects of rabeprazole and omeprazole, when used at the same dose in the treatment of reflux oesophagitis. However, such studies have been conducted as superiority studies but interpreted as equivalence ones. Aim.: To properly assess the comparative efficacy of rabeprazole and omeprazole in inducing complete endoscopic healing and symptom relief in patients with reflux oesophagitis. Methods.: Patients (n = 560) with Savary-Miller grade I-III reflux oesophagitis were randomised in a double-blind, double-dummy fashion to rabeprazole or omeprazole 20 mg once daily for 4-8 weeks. Then, patients endoscopically healed and symptomatically relieved were openly maintained with rabeprazole 10 mg or 2 × 10 mg once daily (in the event of clinical and/or endoscopic relapse) for a maximum of 48 weeks. Results.: After 4-8 weeks of treatment, healing (primary end-point) was observed in 228/233 (97.9%) patients in the rabeprazole group and in 231/237 (97.5%) in the omeprazole one (equivalence effect demonstrated by p < 0.0001 at Blackwelder test and an upper confidence limit at 97.5% of 0.023). However, rabeprazole was faster in inducing heartburn relief than omeprazole (2.8 ± 0.2 versus 4.7 ± 0.5 days of therapy to reach the first day with satisfactory heartburn relief, p = 0.0045 at log-rank test). In the maintenance phase, 15.2% of patients had an endoscopic and/or clinical relapse. Conclusion.: Rabeprazole is equivalent to omeprazole in healing reflux oesophagitis, but shows a faster activity on reflux symptoms in the early treatment phase. © 2005 Editrice Gastroenterologica Italiana S.r.l