A respeito da materialidade do patrimônio imaterial: o caso do INRC Porongos

O colecionamento e a conservação de "bens culturais" vêm ganhando em complexidade pela inclusão de temas oriundos de minorias étnicas e econômicas. Apesar do consenso relativo ao conceito de patrimônio cultural proposto pela Unesco, a definição do que deve ser preservado e celebrado como "bem cultural" pode ser objeto de lutas políticas, jurídicas, econômicas e sociais. Visando refletir sobre as consequências dessas lutas, este artigo aborda o processo de inventário de referências culturais em torno do Massacre de Porongos, evento da Revolução Farroupilha (1835-1845) que vem servindo de apoio à configuração de uma identidade negra e gaúcha no Rio Grande do Sul. Segundo os autores, apesar de se apresentar no registro de "patrimônio imaterial", o processo de inventário possibilitou a fabricação de um "corpo" (de textos e imagens) e a delimitação de "lugares" (de memória) a partir dos quais os referentes culturais ditos "imateriais" vêm se inscrever.<br>The collection and conservation of "cultural objects" has been gaining in complexity with the inclusion of non-material associations regarding ethnic and economic minorities. Despite the consensus on the concept of cultural heritage proposed by Unesco, the definition of what should be preserved and celebrated as "cultural object" may be subject of political, legal, economic and social struggles. In order to reflect upon the consequences of these struggles, this article discusses the process of inventory of cultural references related to the Porongos Massacre, an event of the Farroupilha's Revolution (1835-1845). These cultural references are serving in the configuration of black people's and gauchos identities. According to the authors, althought relating to the "intangible heritage", the process of inventory has enabled the fabrication of a "body" (text and images) and the definition of "places" (from memory) from which the cultural references so-called "non-material" come subscribe

Effect of Sustained Inflations vs Intermittent Positive Pressure Ventilation on Bronchopulmonary Dysplasia or Death Among Extremely Preterm Infants The SAIL Randomized Clinical Trial

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Extending thrombolysis to 4·5–9 h and wake-up stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data

Background: Stroke thrombolysis with alteplase is currently recommended 0–4·5 h after stroke onset. We aimed to determine whether perfusion imaging can identify patients with salvageable brain tissue with symptoms 4·5 h or more from stroke onset or with symptoms on waking who might benefit from thrombolysis. Methods: In this systematic review and meta-analysis of individual patient data, we searched PubMed for randomised trials published in English between Jan 1, 2006, and March 1, 2019. We also reviewed the reference list of a previous systematic review of thrombolysis and searched ClinicalTrials.gov for interventional studies of ischaemic stroke. Studies of alteplase versus placebo in patients (aged ≥18 years) with ischaemic stroke treated more than 4·5 h after onset, or with wake-up stroke, who were imaged with perfusion-diffusion MRI or CT perfusion were eligible for inclusion. The primary outcome was excellent functional outcome (modified Rankin Scale [mRS] score 0–1) at 3 months, adjusted for baseline age and clinical severity. Safety outcomes were death and symptomatic intracerebral haemorrhage. We calculated odds ratios, adjusted for baseline age and National Institutes of Health Stroke Scale score, using mixed-effects logistic regression models. This study is registered with PROSPERO, number CRD42019128036. Findings: We identified three trials that met eligibility criteria: EXTEND, ECASS4-EXTEND, and EPITHET. Of the 414 patients included in the three trials, 213 (51%) were assigned to receive alteplase and 201 (49%) were assigned to receive placebo. Overall, 211 patients in the alteplase group and 199 patients in the placebo group had mRS assessment data at 3 months and thus were included in the analysis of the primary outcome. 76 (36%) of 211 patients in the alteplase group and 58 (29%) of 199 patients in the placebo group had achieved excellent functional outcome at 3 months (adjusted odds ratio [OR] 1·86, 95% CI 1·15–2·99, p=0·011). Symptomatic intracerebral haemorrhage was more common in the alteplase group than the placebo group (ten [5%] of 213 patients vs one [&lt;1%] of 201 patients in the placebo group; adjusted OR 9·7, 95% CI 1·23–76·55, p=0·031). 29 (14%) of 213 patients in the alteplase group and 18 (9%) of 201 patients in the placebo group died (adjusted OR 1·55, 0·81–2·96, p=0·66). Interpretation: Patients with ischaemic stroke 4·5–9 h from stroke onset or wake-up stroke with salvageable brain tissue who were treated with alteplase achieved better functional outcomes than did patients given placebo. The rate of symptomatic intracerebral haemorrhage was higher with alteplase, but this increase did not negate the overall net benefit of thrombolysis