Search for long-lived, massive particles in events with a displaced vertex and a muon with large impact parameter in pp collisions at root s=13 TeV with the ATLAS detector

A search for long-lived particles decaying into hadrons and at least one muon is presented. The analysis selects events that pass a muon or missing-transverse-momentum trigger and contain a displaced muon track and a displaced vertex. The analyzed dataset of proton-proton collisions at √ s = 13 TeV was collected with the ATLAS detector and corresponds to 136 fb − 1. The search employs dedicated reconstruction techniques that significantly increase the sensitivity to long-lived particle decays that occur in the ATLAS inner detector. Background estimates for Standard Model processes and instrumental effects are extracted from data. The observed event yields are compatible with those expected from background processes. The results are presented as limits at 95% confidence level on model-independent cross sections for processes beyond the Standard Model, and interpreted as exclusion limits in scenarios with pair production of long-lived top squarks that decay via a small R -parity-violating coupling into a quark and a muon. Top squarks with masses up to 1.7 TeV are excluded for a lifetime of 0.1 ns, and masses below 1.3 TeV are excluded for lifetimes between 0.01 ns and 30 ns

Processamento auditivo em gagos: análise do desempenho das orelhas direita e esquerda Auditory processing in stutterers: performance of right and left ears

OBJETIVO: Comparar a diferença entre as orelhas nos testes comportamentais do processamento auditivo e os resultados de sujeitos com diferentes graus de gravidade de gagueira em cada teste do processamento auditivo. MÉTODOS: Cinqüenta e seis indivíduos, com idades entre quatro e 34 anos, foram encaminhados pelo Ambulatório de Avaliação Fonoaudiológica da UNIFESP para avaliação comportamental do processamento auditivo. Todos os pacientes foram submetidos à avaliação de audição, fala e linguagem. A disfluência foi classificada segundo o protocolo de Riley (1994), o qual prevê os seguintes graus de gravidade da gagueira: muito leve, leve, moderado, severo e muito severo. Os testes para avaliação do processamento auditivo foram selecionados e analisados de acordo com a idade do paciente e a proposta de Pereira & Schochat (1997). RESULTADOS: Observamos prevalência da gagueira de grau leve nas faixas etárias de quatro a sete anos e de 12 a 34 anos de idade, e de grau moderado nos indivíduos de oito a 11 anos de idade. Dos 56 indivíduos avaliados 92,85% apresentaram alteração do processamento auditivo. Houve diferença estatisticamente significante entre as orelhas direita e esquerda na etapa de atenção direcionada do teste dicótico não verbal, em todas as faixas etárias estudadas. Não foram encontradas diferenças significativas entre os graus de gravidade da gagueira em nenhum dos testes de processamento auditivo. CONCLUSÕES: A orelha direita apresentou melhor desempenho do que a esquerda nos diferentes testes comportamentais. O grau de gravidade da gagueira não interferiu no resultado de cada teste.<br>PURPOSE: To compare the difference between the performances of right and left ears in behavioral tests of auditory processing and to compare the results obtained by subjects with different stuttering severity classifications in each auditory processing test. METHODS: Fifty six subjects (49 male, 7 female), with ages ranging from four to 34 years, were referred to auditory processing evaluation as a complement to speech and language evaluation. All subjects were submitted to auditory, speech and language evaluation. Disfluency severity was classified according to the Riley Stuttering Severity Index as: very mild, mild, moderate, severe and very severe. Behavioral auditory processing tests were selected and analyzed regarding the patients' age and following the proposal of Pereira & Schochat (1997). RESULTS: Mild stuttering was prevalent among subjects with ages ranging from four to seven years and from 12 to 34 years. Moderate stuttering was the most prevalent degree among subjects with eight to 11 years old. Auditory processing disorders were observed in 92,85% of the subjects tested. Significant statistical differences between left and right ears were found in directed attention conditions for the nonverbal dichotic test, in all age ranges. No differences were found among subjects with different stuttering severity classifications in any of the auditory processing tests carried out. CONCLUSIONS: Right ear showed better results than left ear in both monotic and dichotic tests. Stuttering severity didn't interfere with the results of each test

Cardiopulmonary bypass alters the pharmacokinetics of propranolol in patients undergoing cardiac surgery

The pharmacokinetics of propranolol may be altered by hypothermic cardiopulmonary bypass (CPB), resulting in unpredictable postoperative hemodynamic responses to usual doses. The objective of the present study was to investigate the pharmacokinetics of propranolol in patients undergoing coronary artery bypass grafting (CABG) by CPB under moderate hypothermia. We evaluated 11 patients, 4 women and 7 men (mean age 57 ± 8 years, mean weight 75.4 ± 11.9 kg and mean body surface area 1.83 ± 0.19 m²), receiving propranolol before surgery (80-240 mg a day) and postoperatively (10 mg a day). Plasma propranolol levels were measured before and after CPB by high-performance liquid chromatography. Pharmacokinetic Solutions 2.0 software was used to estimate the pharmacokinetic parameters after administration of the drug pre- and postoperatively. There was an increase of biological half-life from 4.5 (95% CI = 3.9-6.9) to 10.6 h (95% CI = 8.2-14.7; P < 0.01) and an increase in volume of distribution from 4.9 (95% CI = 3.2-14.3) to 8.3 l/kg (95% CI = 6.5-32.1; P < 0.05), while total clearance remained unchanged 9.2 (95% CI = 7.7-24.6) vs 10.7 ml min-1 kg-1 (95% CI = 7.7-26.6; NS) after surgery. In conclusion, increases in drug distribution could be explained in part by hemodilution during CPB. On the other hand, the increase of biological half-life can be attributed to changes in hepatic metabolism induced by CPB under moderate hypothermia. These alterations in the pharmacokinetics of propranolol after CABG with hypothermic CPB might induce a greater myocardial depression in response to propranolol than would be expected with an equivalent dose during the postoperative period

Efeito de diferentes temperaturas na qualidade de mandioquinha-salsa minimamente processada Effect of different temperatures on the quality of fresh-cut Peruvian carrot

O objetivo do presente trabalho foi avaliar a vida útil de mandioquinha-salsa 'Amarela de Senador Amaral' minimamente processada e armazenada em três temperaturas de armazenamento. As raízes foram descascadas manualmente, fatiadas (±1 cm de espessura), imersas em solução de dicloro isocianurato de sódio 100 mg L-1 por 15 minutos e acondicionadas em embalagem rígida de polipropileno (15 x 11,5 x 4,5 cm). As embalagens, contendo cerca de 150 g de raízes minimamente processadas, foram armazenadas a 0±1ºC, 5±1ºC ou 10±1ºC durante 15 dias, sendo realizadas análises a cada 3 dias. O delineamento experimental foi inteiramente casualizado em fatorial 3 x 6, sendo 3 temperaturas de armazenamento e 6 períodos de armazenamento, com 3 repetições. O armazenamento a 0ºC determinou, ao longo do armazenamento, aumento nos valores de L* e b*, menores valores de a*, menor atividade da peroxidase, polifenoloxidase, poligalacturonase, solubilização péctica e taxa respiratória, sendo a temperatura mais indicada para o armazenamento da mandioquinha-salsa 'Amarela de Senador Amaral' minimamente processada.<br>The shelf life of fresh-cut Peruvian carrots 'Amarela de Senador Amaral', stored under three temperatures, was evaluated. The roots were peeled manually, sliced (±1 cm thick), immersed in a solution of sodium dichloroisocyanurate 100 mg L-1 during 15 minutes and packed in rigid polypropylene package (15 x 11.5 x 4.5 cm). The packages containing around 150 g of fresh cut roots were stored under 0±1ºC, 5±1ºC or 10±1ºC during 15 days. The analyses were performed every 3 days. The experimental design was completely randomized in a 3 x 6 factorial (3 storage temperature) and 6 periods of storage, with three replicates. The storage at 0ºC provided higher L* and b* values, lower a* values, lower peroxidase, polyphenoloxidase and polygalacturonase activity, pectic solubilization and respiration rate. This temperature is the most proper for the storage of the fresh-cut peruvian carrot 'Amarela de Senador Amaral'