614 research outputs found
Signaling, Resource-Based Power, and Pre-IPO Organizational Change
The theory presented suggests that underwriters are both advisors and independent agents in the issuer’s attempt to send “signals” of quality to investors by making pre-IPO organizational changes. These pre-IPO gambits are intended to increase IPO proceeds, and preemptively address potential investor concerns that would deter them from subscribing. These organizational changes initially can financially benefit founders, early investors and underwriters. But they can also have a longterm impact that some issuers, especially founders, would prefer to avoid. Utilizing signaling and resource-based power, we find that underwriter power is significantly associated with making pre-IPO gambits and lower levels of underpricing
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Development and status of the Evaluated Nuclear Data File ENDF/B
From IAEA conference on physics of fast reactors; Tokyo, Japan (16 Oct 1973). The Evaluated Nuclear Data File is part of a system developed by the USAEC to improve the quality and facilitate the use of nuclear data in applications. The widespread use of a single, welldefined format reduces the number of schemes necessary to process information or compare alternate data sets. A network of checking codes that examine the consistency of the data sets and perform physical checks against known nuclear properties helps to ensure the reliability of the file. The basic elements of the ENDF system are described, and the organization and purposes of the Cross Section Evaluation Working Group (CSEWG) are discussed. (7 figures) (RWR
Height Pairing on Higher Cycles and Mixed Hodge Structures
For a smooth, projective complex variety, we introduce several mixed Hodge
structures associated to higher algebraic cycles. Most notably, we introduce a
mixed Hodge structure for a pair of higher cycles which are in the refined
normalized complex and intersect properly. In a special case, this mixed Hodge
structure is an oriented biextension, and its height agrees with the higher
archimedean height pairing introduced in a previous paper by the first two
authors. We also compute a non-trivial example of this height given by
Bloch-Wigner dilogarithm function. Finally we study the variation of mixed
Hodge structures of Hodge-Tate type, and show that the height extends
continuously to degenerate situations
Plasma Edge Kinetic-MHD Modeling in Tokamaks Using Kepler Workflow for Code Coupling, Data Management and Visualization
A new predictive computer simulation tool targeting the development of the H-mode pedestal at the plasma edge in tokamaks and the triggering and dynamics of edge localized modes (ELMs) is presented in this report. This tool brings together, in a coordinated and effective manner, several first-principles physics simulation codes, stability analysis packages, and data processing and visualization tools. A Kepler workflow is used in order to carry out an edge plasma simulation that loosely couples the kinetic code, XGC0, with an ideal MHD linear stability analysis code, ELITE, and an extended MHD initial value code such as M3D or NIMROD. XGC0 includes the neoclassical ion-electron-neutral dynamics needed to simulate pedestal growth near the separatrix. The Kepler workflow processes the XGC0 simulation results into simple images that can be selected and displayed via the Dashboard, a monitoring tool implemented in AJAX allowing the scientist to track computational resources, examine running and archived jobs, and view key physics data, all within a standard Web browser. The XGC0 simulation is monitored for the conditions needed to trigger an ELM crash by periodically assessing the edge plasma pressure and current density profiles using the ELITE code. If an ELM crash is triggered, the Kepler workflow launches the M3D code on a moderate-size Opteron cluster to simulate the nonlinear ELM crash and to compute the relaxation of plasma profiles after the crash. This process is monitored through periodic outputs of plasma fluid quantities that are automatically visualized with AVS/Express and may be displayed on the Dashboard. Finally, the Kepler workflow archives all data outputs and processed images using HPSS, as well as provenance information about the software and hardware used to create the simulation. The complete process of preparing, executing and monitoring a coupled-code simulation of the edge pressure pedestal buildup and the ELM cycle using the Kepler scientific workflow system is described in this paper
Thyroseq V3 Molecular Profiling for Tailoring the Surgical Management of Hürthle Cell Neoplasms.
Hürthle cell predominant thyroid nodules often confound the diagnostic utility of fine needle aspiration biopsy (FNAB) with cytology often interpreted as a Hürthle cell lesion with an indeterminate risk of malignancy, Bethesda category (BC) III or IV. Molecular diagnostics for Hürthle cell predominant nodules has also been disappointing in further defining the risk of malignancy. We present a case of a slowly enlarging nodule within a goiter initially reported as benign on FNAB, BC II but on subsequent FNAB suspicious for a Hürthle cell neoplasm, BC IV. The patient had initially requested a diagnostic lobectomy for a definitive diagnosis despite a higher risk of malignancy based on the size of the nodule \u3e 4 cm alone. To better tailor this patient\u27s treatment plan, a newer expanded gene mutation panel, ThyroSeq® v3 that includes copy number alterations (CNAs) and was recently found to have greater positive predictive value (PPV) for identifying Hürthle cell carcinoma (HCC), was performed on the FNAB material. Molecular profiling with ThyroSeq® v3 was able to predict a greater risk of carcinoma, making a more convincing argument in favor of total thyroidectomy. Surgical pathology confirmed a Hürthle cell carcinoma with 5 foci of angioinvasion and foci of capsular invasion
Reversible uncoupling of oxidative phosphorylation at low oxygen tension.
The stoichiometry of oxidative phosphorylation at low oxygen tension (
Analysis of proton-induced fragment production cross sections by the Quantum Molecular Dynamics plus Statistical Decay Model
The production cross sections of various fragments from proton-induced
reactions on Fe and Al have been analyzed by the Quantum
Molecular Dynamics (QMD) plus Statistical Decay Model (SDM). It was found that
the mass and charge distributions calculated with and without the statistical
decay have very different shapes. These results also depend strongly on the
impact parameter, showing an importance of the dynamical treatment as realized
by the QMD approach. The calculated results were compared with experimental
data in the energy region from 50 MeV to 5 GeV. The QMD+SDM calculation could
reproduce the production cross sections of the light clusters and
intermediate-mass to heavy fragments in a good accuracy. The production cross
section of Be was, however, underpredicted by approximately 2 orders of
magnitude, showing the necessity of another reaction mechanism not taken into
account in the present model.Comment: 12 pages, Latex is used, 6 Postscript figures are available by
request from [email protected]
Model dependence of single-energy fits to pion photoproduction data
Model dependence of multipole analysis has been explored through
energy-dependent and single-energy fits to pion photoproduction data. The MAID
energy-dependent solution has been used as input for an event generator
producing realistic pseudo data. These were fitted using the SAID
parametrization approach to determine single-energy and energy-dependent
solutions over a range of lab photon energies from 200 to 1200 MeV. The
resulting solutions were found to be consistent with the input amplitudes from
MAID. Fits with a -squared per datum of unity or less were generally
achieved. We discuss energy regions where consistent results are expected, and
explore the sensitivity of fits to the number of included single- and
double-polarization observables. The influence of Watson's theorem is examined
in detail.Comment: 12 pages, 8 figure
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Spheromak Energy Transport Studies via Neutral Beam Injection
Results from the SSPX spheromak experiment provide strong motivation to add neutral beam injection (NBI) heating. Such auxiliary heating would significantly advance the capability to study the physics of energy transport and pressure limits for the spheromak. This LDRD project develops the physics basis for using NBI to heat spheromak plasmas in SSPX. The work encompasses three activities: (1) numerical simulation to make quantitative predictions of the effect of adding beams to SSPX, (2) using the SSPX spheromak and theory/modeling to develop potential target plasmas suitable for future application of neutral beam heating, and (3) developing diagnostics to provide the measurements needed for transport calculations. These activities are reported in several publications
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