A narrative review on the similarities and dissimilarities between myalgic encephalomyelitis/chronic fatigue syndrome (me/cfs) and sickness behavior

It is of importance whether myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a variant of sickness behavior. The latter is induced by acute infections/injury being principally mediated through proinflammatory cytokines. Sickness is a beneficial behavioral response that serves to enhance recovery, conserves energy and plays a role in the resolution of inflammation. There are behavioral/symptomatic similarities (for example, fatigue, malaise, hyperalgesia) and dissimilarities (gastrointestinal symptoms, anorexia and weight loss) between sickness and ME/CFS. While sickness is an adaptive response induced by proinflammatory cytokines, ME/CFS is a chronic, disabling disorder, where the pathophysiology is related to activation of immunoinflammatory and oxidative pathways and autoimmune responses. While sickness behavior is a state of energy conservation, which plays a role in combating pathogens, ME/CFS is a chronic disease underpinned by a state of energy depletion. While sickness is an acute response to infection/injury, the trigger factors in ME/CFS are less well defined and encompass acute and chronic infections, as well as inflammatory or autoimmune diseases. It is concluded that sickness behavior and ME/CFS are two different conditions

Supervision trajectories of male juvenile offenders: growth mixture modeling on SAVRY risk assessments

Background: Structured risk/need assessment tools are increasingly used to orientate risk reduction strategies with juvenile offenders. The assumption is that the risk/need items on these tools are sufficiently sensitive to measure changes in the individual, family and/or contextual characteristics of juvenile offenders. However, there is very little research demonstrating the capacity of these tools to measure changes in juvenile offenders. Congruent with the developmental and life-course criminology theories (DLC) the objective of this study is to explore the existence of heterogeneous trajectories of juvenile offenders across the juvenile justice system as measured through five empirical risk/need areas based on the Structured Assessment of Violence Risk in Youth (SAVRY), one of the most widely applied risk assessment tools for juveniles. Methods: This longitudinal study included 5205 male juvenile offenders who transitioned through the Catalan juvenile justice system between 2006 and 2014. During intervention they received at least two, and a maximum of seven, consecutive SAVRY risk/need assessments over an 18-month period. The heterogeneity of latent class trajectories was explored through growth mixture modeling (GMM). The trajectory class membership was linked to covariates through multinomial logistic regression analyses. Results: Through GMM three to four heterogeneous trajectories, with high quality of separation, were identified in each of the risk/need areas. The trajectories with low risk/needs (45-77% of the sample) remained low and presented a very limited increase in risk/needs during the 18-month period. The high risk/need trajectories (20-37% of the sample) showed a limited decrease or no change. Between 5 and 13% of the sample had large reductions in their risk/needs levels, and approximately 5% showed a large increase in risk/needs. Conclusions: In line with the DLC theories this study shows that trajectories on criminogenic risk/needs can be heterogeneous and indicate distinct rates of change over time. The results of this study also may suggest a limited sensibility to measure change over time of SAVRY's risk and protective items. Suggestions to improve the sensitivity of measuring change over time, such as shorter time frames or future-oriented time frames for the scoring of the items, are offered

Emerging Early Actions to Bend the Curve in Sub-Saharan Africa’s Nutrition Transition

BACKGROUND : Sub-Saharan Africa is the last region to undergo nutrition transition and can still avoid its adverse health outcomes. OBJECTIVE : The paper explores emerging responses to ―bend the curve‖ in sub-Saharan Africa‘s nutrition transition to steer public health outcomes onto a healthier trajectory. METHODS : Early responses in three countries at different stages in food system transformation are examined: South Africa -advanced, Ghana –intermediate, and Uganda -early. By comparing these with international experience, actions are proposed to influence nutrition and public health trajectories as Africa‘s food systems undergo rapid structural change. RESULTS : Arising from rapid urbanization and diet change, major public health problems associated with overweight are taking place, particularly in South Africa and among adult women. However, public health responses are generally tepid in sub-Saharan Africa. Only in South Africa have policy makers instituted extensive actions to combat overweight and associated non-communicable diseases through regulation, education and public health programmes. Elsewhere, in countries in the early and middle stages of transition, public health systems continue to focus their limited resources primarily on under-nutrition. Related pressures on the supply side of Africa‘s food systems are emerging that also need to be addressed. CONCLUSIONS :Three types of intervention appear most feasible: Maternal and child health programmes to simultaneously address short-term undernutrition problems while at the same time helping to reduce future tendencies towards overweigh; Regulatory and fiscal actions to limit access to unhealthy foods; Modernization of Africa‘s agrifood food system, through job skills training, marketing reforms and food industry entrepreneurship.http://www.elsevier.com /locate/compind2017-06-30hb2016Food Scienc

Pesticidal plants for stored product pests on small-holder farms in Africa

Despite the near elimination of pests from food stores in industrialised nations, insects are still the most important challenge to food security for small-holder farmers in less developed nations. Losses are frequently as high as 20 %. Synthetic products provide effective control when used correctly but are not sustainable or universally appropriate and present many challenges for farmers, not least of all their cost. Pesticidal plants offer an economic, effective and often the only alternative. Much published research, however, overlooks critical knowledge gaps providing outputs that are unlikely to improve pesticidal plant use or improve food security. This chapter identifies opportunities for better targeted research and improvements for uptake and use of pesticidal plants. We also highlight how a deeper understanding of different morphs, gender and age of insect can influence experimental results and should be considered more carefully. To be effective plant materials need to show low animal and environmental toxicity at typical application levels but at the same time be effective against a wide range of target species, at low doses and with longevity. They must also be low cost, safe, compatible with other pest management technologies and stable and have no consequences for the stored products such as impairing flavour. Research should be targeted at optimising the efficacy of the pesticidal plants already known to have potential, and this should be supported by chemistry to fully understand spatial, temporal and phenotypic variability and nontarget impacts. Availability of plants is a limiting factor to uptake so propagation and cultivation of elite provenances would alleviate pressure on natural ecosystems and improve reliability of efficacy and supply when supported by improved harvesting techniques. The large-scale commercialisation of plants may not compete with synthetic products globally but local production may foster a mechanism to support and encourage uptake through local markets and value chains