Large magnetoresistance and finite-size effects in electrodeposited single-crystal bi thin films

Trigonal-axis oriented single-crystal Bi thin films have been made by electrodeposition followed by suitable annealing. Very large magnetoresistance with ratios as much as 1500 at 5 K and 2.9 at 300 K under 5 T, Shubnikov-de Haas oscillations, and finite-size effects have been observed. © 1999 The American Physical Society

Perpendicular giant magnetoresistance of multilayered Co/Cu nanowires.

We have successfully fabricated multilayered Co/Cu nanowires with different diameters and various layer thicknesses by electrodeposition. They display a large perpendicular giant magnetoresistance up to 11% at room temperature and 22% at 5 K. The spin-flip diffusion length has been directly measured to be about 210 for this system. © 1995 The American Physical Society

Large magnetoresistance and finite-size effects in electrodeposited single-crystal bi thin films

Trigonal-axis oriented single-crystal Bi thin films have been made by electrodeposition followed by suitable annealing. Very large magnetoresistance with ratios as much as 1500 at 5 K and 2.9 at 300 K under 5 T, Shubnikov-de Haas oscillations, and finite-size effects have been observed. © 1999 The American Physical Society

Perpendicular giant magnetoresistance of multilayered Co/Cu nanowires.

We have successfully fabricated multilayered Co/Cu nanowires with different diameters and various layer thicknesses by electrodeposition. They display a large perpendicular giant magnetoresistance up to 11% at room temperature and 22% at 5 K. The spin-flip diffusion length has been directly measured to be about 210 for this system. © 1995 The American Physical Society

Structural and magneto-transport properties of electrodeposited bismuth nanowires

Arrays of semimetallic Bi nanowires have been successfully fabricated by electrodeposition. Each nanowire consists of elongated Bi grains along the wire direction. Very large positive magnetoresistance of 300% at low temperatures and 70% at room temperature with quasilinear field dependence has been observed. These features are desirable for wide-range field sensing applications. © 1998 American Institute of Physics

Optical coding of fusion genes using multicolor quantum dots for prostate cancer diagnosis

Hyojin Lee,1,* Chloe Kim,2,* Dongjin Lee,1,3,* Jea Ho Park,1,2 Peter C Searson,2 Kwan Hyi Lee1,3 1Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea; 2Department of Materials Science and Engineering, 3Department of Biomedical Engineering, Korea University of Science and Technology (UST), Daejeon, Republic of Korea *These authors contributed equally to this work Abstract: Recent studies have found that prostate cancer expresses abnormal genetic markers including multiple types of TMPRSS2–ERG fusion genes. The expression level of different TMPRSS2–ERG fusion genes is correlated to pathologic variables of aggressive prostate cancer and disease progression. State-of-the-art methods for detection of TMPRSS2–ERG fusion genes include reverse transcription polymerase chain reaction (RT-PCR) with a detection limit of 1 fmol at urinary condition. RT-PCR is time consuming, costly, and inapplicable for multiplexing. Ability to identify multiple fusion genes in a single sample has become important for diagnostic and clinical purposes. There is a need for a sensitive diagnostic test to detect multiple TMPRSS2–ERG fusion genes for an early diagnosis and prognosis of prostate cancer. Here, we propose to develop an assay for prostate cancer diagnosis using oligonucleotide-functionalized quantum dot and magnetic microparticle for optical detection of rearranged TMPRSS2–ERG fusion genes at a low concentration in urine. We found that our assay was able to identify three different types of fusion gene with a wide detection range and detection limit of 1 fmol (almost the same level of the RT-PCR result reported). Here, we show detection of multiple TMPRSS2–ERG fusion genes using color-coded oligonucleotides in cell lysate and urine. Keywords: fusion genes, prostate cancer, quantum dots, multiplexed assay, optical detectio

Diagnosis of prostate cancer via nanotechnological approach

Benedict J Kang,1,2,* Minhong Jeun,1,2,* Gun Hyuk Jang,1,2 Sang Hoon Song,3 In Gab Jeong,3 Choung-Soo Kim,3 Peter C Searson,4 Kwan Hyi Lee1,2 1KIST Biomedical Research Institute, 2Department of Biomedical Engineering, Korea University of Science and Technology (UST), 3Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; 4Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD, USA *These authors contributed equally to this work Abstract: Prostate cancer is one of the leading causes of cancer-related deaths among the Caucasian adult males in Europe and the USA. Currently available diagnostic strategies for patients with prostate cancer are invasive and unpleasant and have poor accuracy. Many patients have been overly or underly treated resulting in a controversy regarding the reliability of current conventional diagnostic approaches. This review discusses the state-of-the-art research in the development of novel noninvasive prostate cancer diagnostics using nanotechnology coupled with suggested diagnostic strategies for their clinical implication.Keywords: bioassay, nanomaterial, nanodevice, PSA, non-PSA biomarker, bodily flui