29 research outputs found
Efficacious Recombinant Influenza Vaccines Produced by High Yield Bacterial Expression: A Solution to Global Pandemic and Seasonal Needs
- Author
- AJ Caton
- Albert Price
- Andrea Jacobs
- DC Wiley
- DJ Smith
- DN Hebert
- Douglas F. Nixon
- ED Kilbourne
- Gail Maksymiuk
- Ge Liu
- Hong Li
- IA Wilson
- Jie Tang
- Jim Huleatt
- JM Blander
- JM Blander
- JW Huleatt
- JW Huleatt
- Langzhou Song
- Lucia Reiserova
- Lynda Tussey
- PB Rosenthal
- Priyanka Desai
- RA Bright
- RJ Russell
- Rodney Bell
- Scott Umlauf
- SH Jeon
- SJ Gamblin
- T Bizebard
- T. J. Powell
- Uma Kavita
- Valerian Nakaar
- Virginia Takahashi
- WF McDonald
- William F. McDonald
- Y Ha
- Yan Huang
- Yi Zhang
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2008
- Field of study
It is known that physical linkage of TLR ligands and vaccine antigens significantly enhances the immunopotency of the linked antigens. We have used this approach to generate novel influenza vaccines that fuse the globular head domain of the protective hemagglutinin (HA) antigen with the potent TLR5 ligand, flagellin. These fusion proteins are efficiently expressed in standard E. coli fermentation systems and the HA moiety can be faithfully refolded to take on the native conformation of the globular head. In mouse models of influenza infection, the vaccines elicit robust antibody responses that mitigate disease and protect mice from lethal challenge. These immunologically potent vaccines can be efficiently manufactured to support pandemic response, pre-pandemic and seasonal vaccines
FUTURE PERSPECTIVES IN MELANOMA RESEARCH. Meeting report from the âMelanoma Research: a bridge from Naples to the World. Napoli, December 5thâ6 th2011â
- Author
- AA Tarhini
- AA Tarhini
- AJ Thomas
- AM Di Giacomo
- Antoni Ribas
- Antonio M Grimaldi
- Axel Hauschild
- Bernard A Fox
- Brendan Curti
- C Robert
- CM Balch
- CM Balch
- CM Balch
- David F Stroncek
- DF Stroncek
- Donald L Morton
- EL Korn
- Ena Wang
- EV Abel
- F Stephen Hodi
- Franco M Marincola
- FS Hodi
- FS Hodi
- Giuseppe Palmieri
- H Gogas
- Helen Gogas
- I Puzanov
- J Jin
- JA Jakob
- JE Gershenwald
- Jeffrey E Gershenwald
- JF Thompson
- JM Kirkwood
- John M Kirkwood
- JR Infante
- K Curran
- K Curran
- K Wheatley
- K Wheatley
- KB Kim
- Keith Flaherty
- Kenneth Grossmann
- L Gattinoni
- MA Davies
- Mark B Faries
- ME Dudley
- Michele Maio
- Nicola Mozzillo
- P Katiyar
- PA Ascierto
- Paolo A Ascierto
- PB Chapman
- PF Robbins
- RA Stewart
- Richard Kefford
- Richard Marais
- Rodney Stewart
- S Mocellin
- SA Rosenberg
- Sancy Leachmann
- SJ Soong
- Soldano Ferrone
- SS Agarwala
- T Tatsumi
- Thomas F Gajewski
- TL Bowles
- Publication venue
- BioMed Central
- Publication date
- 01/01/2012
- Field of study
After more than 30 years, landmark progress has been made in the treatment of cancer, and melanoma in particular, with the success of new molecules such as ipilimumab, vemurafenib and active specific immunization
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
- Author
- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
- Abdoli A
- Abel S
- Abeliovich H
- Abildgaard MH
- Abudu YP
- Acevedo-Arozena A
- Adamopoulos IE
- Adeli K
- Adolph TE
- Adornetto A
- Aflaki E
- Agam G
- Agarwal A
- Aggarwal BB
- Agnello M
- Agostinis P
- Agrewala JN
- Agrotis A
- Aguilar PV
- Ahmad ST
- Ahmed ZM
- Ahumada-Castro U
- Aits S
- Aizawa S
- Akkoc Y
- Akoumianaki T
- Akpinar HA
- Al-Abd AM
- Al-Akra L
- Al-Gharaibeh A
- Alaoui-Jamali MA
- Alberti S
- Alcocer-GĂłmez E
- Alessandri C
- Ali M
- Alim Al-Bari MA
- Aliwaini S
- Alizadeh J
- Almacellas E
- Almasan A
- Alonso A
- Alonso GD
- Altan-Bonnet N
- Altieri DC
- Alves da Costa C
- Alves S
- Alzaharna MM
- Amadio M
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- Amaral C
- Ambrosio S
- Amer AO
- Ammanathan V
- An Z
- Andersen SU
- Andrabi SA
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- Andres AM
- Angelini S
- Ann D
- Anozie UC
- Ansari MY
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- Zang QS
- Zanivan S
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- Zaragoza P
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- Zhivotovsky B
- Zhong Q
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- Zhu B
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- Zhu G-Q
- Zhu H
- Zhu H
- Zhu H
- Zhu W-G
- Zhu Y
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- Zhuang H
- Zhuang X
- Zientara-Rytter K
- Zimmermann CM
- Ziviani E
- Zoladek T
- Zong W-X
- Zorov DB
- Zorzano A
- Zou W
- Zou Z
- Zou Z
- Zuryn S
- Zwerschke W
- Ălvarez ĂMC
- Ăvalos Y
- Ănal G
- ĂstĂŒn S
- ÄoliÄ M
- ÄokiÄ J
- Ćœerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Large-scale sequencing identifies multiple genes and rare variants associated with Crohnâs disease susceptibility
- Author
- Abreu Maria T
- Ahmad Tariq
- Allez Matthieu
- Ananthakrishnan Ashwin N
- Anderson Carl A
- Atzmon Gil
- Avila Brandon
- Baras Aris
- Barrett Jeffrey C
- Barzilai Nir
- Beaugerie Laurent
- Beecham Ashley
- Belgium IBD Consortium
- Bernstein Charles N
- Bitton Alain
- Bokemeyer Bernd
- Brant Steven R
- Cedars-Sinai IBD
- Chan Andrew
- Cho Judy
- Chung Daniel
- Cleynen Isabelle
- Cosnes Jacques
- Cutler David J
- Daly Allan
- Daly Mark J
- Damas Oriana M
- Datta Lisa W
- Dawany Noor
- Devoto Marcella
- Dodge Sheila
- Duerr Richard H
- Ellinghaus Eva
- Fachal Laura
- Farkkila Martti
- Faubion William
- Ferreira Manuel
- Franchimont Denis
- Franke Andre
- Gabriel Stacey B
- Ge Tian
- Georges Michel
- Gettler Kyle
- Giri Mamta
- Glaser Benjamin
- Goerg Siegfried
- Goyette Philippe
- Graham Daniel
- Haritunians Talin
- Heap Graham A
- Hiltunen Mikko
- Hoeppner Marc
- Horowitz Julie E
- Huang Hailiang
- HÀmÀlÀinen Eija
- International IBD Genetics Consortium
- Irving Peter
- Iyer Vivek
- Jalas Chaim
- Kelsen Judith
- Khalili Hamed
- Kirschner Barbara S
- Kontula Kimmo
- Koskela Jukka T
- Kugathasan Subra
- Kupcinskas Juozas
- Lamb Christopher A
- Laudes Matthias
- Levine Adam P
- Lewis James D
- Liefferinckx Claire
- Loescher Britt-Sabina
- Louis Edouard
- Lévesque Chloé
- Mansfield John
- May Sandra
- McCauley Jacob L
- McGovern Dermot PB
- Mengesha Emebet
- Mni Myriam
- Moayyedi Paul
- Moran Christopher J
- Newberry Rodney D
- NIDDK IBD Genetics Consortium
- NIHR IBD BioResource
- O'Charoen Sirimon
- Okou David T
- Oldenburg Bas
- Ostrer Harry
- Palotie Aarno
- Paquette Jean
- Parkes Miles
- Pekow Joel
- Peter Inga
- Pierik Marieke J
- Ponsioen Cyriel Y
- Pontikos Nikolas
- Prescott Natalie
- Pulver Ann E
- Rahmouni Souad
- Regeneron Genetics Center
- Rice Daniel L
- Rioux John D
- Rivas Manuel A
- Saavalainen PĂ€ivi
- Sands Bruce
- Sartor R Balfour
- Sazonovs Aleksejs
- Schiff Elena R
- Schreiber Stefan
- Schumm L Philip
- Segal Anthony W
- Seksik Philippe
- SHARE Consortium
- Shawky Rasha
- Sheikh Shehzad Z
- Silverberg Mark S
- Simmons Alison
- Skeiceviciene Jurgita
- Sokol Harry
- Solomonson Matthew
- Somineni Hari
- SPARC IBD Network
- Stevens Christine R
- Sun Dylan
- Targan Stephan
- Turner Dan
- Uhlig Holm H
- UK IBD Genetics Consortium
- van der Meulen Andrea E
- Venkataraman Guhan R
- Vermeire SĂ©verine
- Verstockt Sare
- Voskuil Michiel D
- Weersma Rinse K
- Winter Harland S
- Xavier Ramnik J
- Young Justine
- Yuan Kai
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 29/08/2022
- Field of study
peer reviewe
On Markov Equilibria in Dynamic Inventory Competition
- Author
- Publication venue
- 'Institute for Operations Research and the Management Sciences (INFORMS)'
- Publication date
- Field of study
The RecQ DNA Helicases in DNA Repair
- Author
- Publication venue
- 'Annual Reviews'
- Publication date
- 01/01/2010
- Field of study
International audienceThe RecQ helicases are conserved from bacteria to humans and play a critical role in genome stability. In humans, loss of RecQ gene function is associated with cancer predisposition and/or premature aging. Recent experiments have shown that the RecQ helicases function during distinct steps during DNA repair; DNA end resection, displacement-loop (D-loop) processing, branch migration, and resolution of double Holliday junctions (dHJs). RecQ function in these different processing steps has important implications for its role in repair of double-strand breaks (DSBs) that occur during DNA replication and meiosis, as well as at specific genomic loci such as telomeres
Enclaves and Development: An Empirical Assessment
- Author
- A Heston
- A Winson
- AO Hirschman
- BR Mitchell
- BR Mitchell
- C Chase-Dunn
- CF Diaz-Alejandro
- D Acemoglu
- D Acemoglu
- D Acemoglu
- D Acemoglu
- D Acemoglu
- D Acemoglu
- DA Yarrington
- DC North
- FH Cardoso
- FH Cardoso
- HS Klein
- James A. Robinson
- JM Paige
- Jonathan H. Conning
- P Hill
- PB Evans
- PB Evans
- PB Evans
- PB Evans
- R Pankhurst
- R Szereszewski
- RE Hall
- RG Williams
- S Baier
- SL Engerman
- SL Engerman
- V Bulmer-Thomas
- W Rodney
- W Roseberry
- WG Clarence-Smith
- World Bank
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The RecQ DNA Helicases in DNA Repair
- Author
- Publication venue
- 'Annual Reviews'
- Publication date
- Field of study
Fabrication, simulations, and measurements of self-assembled millimeter-wave antennas for system-on-chip applications
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
WATCHMAN implantation in patients with a history of atrial fibrillation and intracranial hemorrhage
- Author
- A Majeed
- A Tzikas
- Andrea Natale
- Carola Gianni
- Dhanunjaya Lakkireddy
- Donita Atkins
- DR Holmes
- E Hutt
- E. Kevin Heist
- GF Tomaselli
- Jennifer Galvin
- Jeremy Ruskin
- Joshua A. Cohen
- Luigi Di Biase
- LV Boersma
- M. Edip Gurol
- ME Gurol
- Moussa Mansour
- P Fahmy
- P Renou
- PB Nielsen
- PB Nielsen
- Rodney Horton
- Sanghamitra Mohanty
- SR Dukkipati
- Sudha Bommana
- VY Reddy
- William J. Hucker
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study