Constructing Dirac linear fermions in terms of non-linear Heisenberg spinors

We show that the massive (or massless) neutrinos can be described as special states of Heisenberg nonlinear spinors. As a by-product of this decomposition a particularly attractive consequence appears: the possibility of relating the existence of only three species of mass-less neutrinos to such internal non-linear structure. At the same time it allows the possibility that neutrino oscillation can occurs even for massless neutrinos

MULTIFREQUENCY SURVEY OF THE INTERGALACTIC CLOUD IN THE M96 GROUP

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Historical perspectives in kidney transplantation: an updated review

The present state of success in kidney transplantation, including its benefits to patients with end-stage renal failure, was achieved through relentless research, both in experimental animal models and human volunteers. Kidney transplantation has evolved during the past century thanks to various milestones in surgical techniques, immunology, immunosuppressive drugs, expansion of donor sources, organ preservation, transplant against immunological barriers (ABO blood group-incompatible and positive crossmatch transplants), and research on induction of tolerance, xenotransplants, and stem cell technology. Despite significant improvements in graft and patient survival, several issues still must be addressed to reduce the growing number of patients with kidney failure waiting to receive organs. This article provides an up-to-date review of the milestones in the history of kidney transplantation and highlights strategies to resolve current problems faced by patients and the transplant community

Who’ll pay reparations on my soul?: social control and social suffering in Argentina

Contemporary debate about compensation for past wrongs turns on the assumption that state reparation benefits the victims of atrocity by acknowledging harm and ameliorating victim suffering. Indeed, much recent theoretical and practical work has concurred to establish reparation to victims of state crimes as a cornerstone of human rights. However, this article argues that reparation can also function to placate victim demands for criminal justice and to regulate the range of political and historical meanings with which the crimes of the past are endowed. This is most evident in transitional political contexts in which gestures of reparation are usually concomitant with the inauguration of new political orders, and formal investigations of past atrocity are conditioned by the balancing of the political demands of new and old regimes. This article argues that in such contexts, state reparation can work to control social suffering with the consequence that it sometimes intensifies rather than alleviates it. To evidence this claim, the article investigates the refusal of reparations by the victims towards whom it is addressed, with reference to Argentina’s Madres de Plaza de Mayo. This analysis of their refusal demonstrates how victim groups make important challenges to some of the core assumptions in the field, reveals internal inconsistencies within the analytical architecture of the scholarly and professional discourse, and indicates the ways in which reparations carry political, and not just palliative, significance

Modulation of cystic fibrosis lung disease by variants in interleukin-8

Cystic fibrosis pulmonary disease is characterized by excessive and prolonged inflammation. CF Pulmonary disease severity exhibits considerable variation that, to some extent, appears to be due to the presence of modifier genes. Several components of the inflammatory response are known to have altered regulation in the CF lung. Genetic variants in 52 inflammatory genes were tested for associations with lung disease indices in a CF patient population (n=737) homozygous for the ΔF508 cystic fibrosis transmembrane conductance regulator mutation. Variants in 3 inflammatory genes showed significant genotypic associations with CF lung disease severity, including IL8 and previously reported TGFβ1(1) (p≤0.05). When analyzed by gender, it was apparent that IL8 variant associations were predominantly due to males. The IL8 variants were tested in an additional CF population (n=385) and the association in males verified (p≤0.01). The IL8 variants were in strong linkage disequilibrium with each other (R(2)≥0.82), while variants in neighboring genes CXCL6, RASSF6 and PF4V1 did not associate (p≥0.26) and were in weaker LD with each other and with the IL8 variants (0.01≤R(2)≤0.49). Studies revealed differential expression between the IL8 promoter variant alleles (p<0.001). These results suggest that IL8 variants modify CF lung disease severity and have functional consequences