Isolated Third Cranial Nerve Palsy Leading to the Diagnosis of Disseminated Burkitt Lymphoma: A Case Report and Literature Review

Dysfunction of the third cranial nerve can result from lesions anywhere along its course between the midbrain and the orbit. Lymphoma is a rare cause of isolated oculomotor nerve palsy (OMP), with only 19 cases reported in the literature. We describe a case of an isolated OMP leading to the diagnosis of disseminated Burkitt lymphoma (BL)

Time delay reservoir computing with a silicon microring resonator and a fiber-based optical feedback loop

Silicon microring resonators serve as critical components in integrated photonic neural network implementations, owing to their compact footprint, compatibility with CMOS technology, and passive nonlinear dynamics. Recent advancements have leveraged their filtering properties as weighting functions, and their nonlinear dynamics as activation functions with spiking capabilities. In this work, we investigate experimentally the linear and nonlinear dynamics of microring resonators for time delay reservoir computing, by introducing an external optical feedback loop. After effectively mitigating the impact of environmental noise on the fiber-based feedback phase dependencies, we evaluate the computational capacity of this system by assessing its performance across various benchmark tasks at a bit rate of few Mbps. We show that the additional memory provided by the optical feedback is necessary to achieve error-free operation in delayed-boolean tasks that require up to 3 bits of memory. In this case the microring was operated in the linear regime and the photodetection was the nonlinear activation function. We also show that the Santa Fe and Mackey Glass prediction tasks are solved when the microring nonlinearities are activated. Notably, our study reveals competitive outcomes even when employing only 7 virtual nodes within our photonic reservoir. Our findings illustrate the silicon microring’s versatile performance in the presence of optical feedback, highlighting its ability to be tailored for various computing applications

The impact of reproductive life on breast cancer risk in women with family history or BRCA mutation

Reproductive history and exogenous hormonal exposures are acknowledged risk factors for breast cancer in the general population. In women at increased breast cancer risk for genetic predisposition or positive family history, data regarding these risk factors are limited or con icting, and recommendations for these categories are unclear. We evaluated the characteristics of reproductive life in 2522 women at increased genetic or familial breast cancer risk attending our Family Cancer Center. Breast cancers in BRCA mutation carriers were more likely to be hormone receptor negative, diagnosed at 35 years or before and multiple during the lifetime than tumors in women at increased familial risk, while the distribution of invasive cancers and HER2 positive tumors was similar in the different risk groups. At least one full- term pregnancy (HR 0.27; 95% CI 0.12\u20130.58; p = 0.001), breastfeeding either less (HR 0.24; 95% CI 0.09\u20130.66; p = 0.005) or more (HR 0.25; 95% IC 0.08\u20130.82; p = 0.022) than one year and late age at menopause (HR 0.10; 95% CI 0.01\u20130.82; p = 0.033) showed to be protective factors in BRCA mutation carriers, while in women at increased familial risk early age at rst full-term pregnancy (HR 0.62; 95% IC 0.38\u20130.99; p = 0.048) and late menarche (HR 0.61; 95% CI 0.42\u20130.85; p = 0.004) showed to be the main protective factors. Finally, for the entire population, combined hormonal contraceptives demonstrated to do not increase breast cancer risk. The results of our study suggest that women at high familial risk and mutation carries develop tumors with different clinical-pathological characteristics and, consequently, are in uenced by different protective and risk factors

A combined protocol with piroxicam, chemotherapy and whole pelvic irradiation with simultaneous boost volumetric modulated arc radiotherapy for muscle-invasive canine urinary transitional cell carcinoma: first clinical experiences

The aims of this pilot study were to evaluate the feasibility and efficacy of high-dose hypo-fractionated volumetric modulated arc radiotherapy (VMAT) applied to the whole pelvic region radiotherapy (WPRT) with multilevel simultaneous integrated boost (MLSIB) combined with piroxicam and chemotherapy in canine transitional cell carcinoma (TCC) of the lower urinary tract with muscle invasion transitional cell carcinoma (TCC). Twelve dogs were enrolled, according to stage, in two groups: group 1, TCC confined to the urinary tract; group 2, TCC with metastasis. The planning target volume (PTV-tumor) dose was tailored from 36 to 42 Gy in 6 fractions. All dogs were prescribed piroxicam and radiosensitizing carboplatin and six received chemotherapy after radiotherapy. Serial follow-up with computed tomography (CT) and magnetic resonance imaging (MRI) examinations was performed. Disease control and toxicity effects were evaluated according to the Response Evaluation Criteria in Solid Tumor (RECIST) and Veterinary Radiation Therapy Oncology Group (VRTOG) criteria. The treatment was well tolerated, and no high-grade side effects were reported. The median overall survival times for group 1 and group 2 were 1,230 days and 150 days, respectively. A considerable percentage of patients in group 1 (50%) was still alive at the time of writing, and a longer follow-up could enable a more accurate survival analysis. This preliminary analysis showed that VMAT applied to the WPRT with MLSIB is an effective and safe option for dogs suffering from lower urinary TCC although the presence of metastases worsens the prognosis

Autologous anti-GD2 CAR T cells efficiently target primary human glioblastoma

Glioblastoma (GBM) remains a deadly tumor. Treatment with chemo-radiotherapy and corticosteroids is known to impair the functionality of lymphocytes, potentially compromising the development of autologous CAR T cell therapies. We here generated pre-clinical investigations of autologous anti-GD2 CAR T cells tested against 2D and 3D models of GBM primary cells. We detected a robust antitumor effect, highlighting the feasibility of developing an autologous anti-GD2 CAR T cell-based therapy for GBM patients

Insights into healthcare professionals’ perceptions and attitudes toward nanotechnological device application: What is the current situation in glioblastoma research?

Nanotechnology application in cancer treatment is promising and is likely to quickly spread worldwide in the near future. To date, most scientific studies on nanomaterial development have focused on deepening the attitudes of end users and experts, leaving clinical practice implications unexplored. Neuro-oncology might be a promising field for the application of nanotechnologies, especially for malignant brain tumors with a low-survival rate such as glioblastoma (GBM). As to improving patients’ quality of life and life expectancy, innovative treatments are worth being explored. Indeed, it is important to explore clinicians’ intention to use experimental technologies in clinical practice. In the present study, we conducted an exploratory review of the literature about healthcare workers’ knowledge and personal opinions toward nanomedicine. Our search (i) gives evidence for disagreement between self-reported and factual knowledge about nanomedicine and (ii) suggests the internet and television as main sources of information about current trends in nanomedicine applications, over scientific journals and formal education. Current models of risk assessment suggest time-saving cognitive and affective shortcuts, i.e., heuristics support both laypeople and experts in the decision-making process under uncertainty, whereas they might be a source of error. Whether the knowledge is poor, heuristics are more likely to occur and thus clinicians’ opinions and perspectives toward new technologies might be biased

Comparação fotointerpretativa entre aerofoto e imagem de satélite

http://dx.doi.org/10.5902/198050989298This study evaluated the result of different methodologies in determining the use and occupancy of land using digital aerial photographs with spatial resolution of 1m (scenario 01) and satellite imagery with a spatial resolution of 0.5 m ( scenario 02), photo-interpreted screen, on a scale of 1:2.000 mapping, watershed ‘Horizonte’ stream, in Alegre, ES state. We used the global performance indices and Kappa index for determining the average error between the sets and t test at 5% probability to assess the degree of significance in the process of image interpretation between scenarios 01 and 02. We identified 27 classes of land use for scenarios 01 and 02. The classes of pasture (599.62 and 442.43 ha) and forest fragmentation (319.45 and 258.07 ha) respectively, occupying the largest areas in the two scenarios, composing 69.80% for scenario 01 and 53.04% for scenario 02 of the total area. There was a positive variation of 6.67% in the DG scenario in scenarios 01 and 02. However, the K shows that the scenario 02 has a lower rate of errors of omission and commission of 2.09%, but does not present significance by the statistical analysis presented at 5% level by t test.http://dx.doi.org/10.5902/198050989298Este estudo objetivou avaliar o uso de diferentes metodologias na determinação do uso e ocupação da terra utilizando aerofotos digitais, com resolução espacial de 1 m (cenário 01) e imagens de satélite, com resolução espacial de 0,5 m (cenário 02), fotointerpretadas em tela, na escala cartográfica de 1:2.000, da bacia hidrográfica do córrego Horizonte, Alegre-ES. Utilizaram-se os índices de desempenho global e índice Kappa para determinação do erro médio entre os cenários e teste t a 5 % de probabilidade para avaliar o grau de significância no processo de fotointerpretação entre os cenários 01 e 02. Foram identificadas 27 classes de uso da terra para os cenários 01 e 02. As classes de pastagem (599,62 e 442,43 ha) e fragmento florestal (319,45 e 258,07 ha) respectivamente, ocupando maiores áreas nos dois cenários, compondo 69,80 % para o cenário 01 e 53,04 % para o cenário 02 das áreas totais. Verificou-se uma variação positiva do DG em 6,67 % do cenário 01 em relação ao cenário 02. Entretanto o K demonstra que o cenário 02 possui uma menor taxa entre os erros de omissão e comissão em 2,09 %, não apresentado significância pela análise estatística em nível de 5 % pelo teste t

When sleep-related hypermotor epilepsy (SHE) met Charles Darwin and Francis Galton

Sleep-related hypermotor epilepsy (SHE) is characterized by short-lasting seizures patterned by repetitive and stereotyped motor events in the same person. In autosomal dominant SHE, genetic factors play a well-known key role. In The Expression of Emotions in Man and Animals, Charles Darwin quotes a plausible example of SHE illustrated by his cousin Sir Francis Galton: "the gentleman…lay fast asleep on his back in bed, raising his right arm slowly in front of his face, up to his forehead, and then dropping it with a jerk, so that the wrist fell heavily on the bridge of his nose. The trick did not occur every night, but occasionally, and was independent of any ascertained cause. Sometimes it was repeated incessantly for an hour or more." Similar manifestations during sleep occurred also in the patient's son and granddaughter, suggesting an autosomal inheritance without sex relationship. Differential diagnosis with REM behavior disorder and other parasomnias is discussed. To our knowledge, this could be the first description of a stereotyped SHE pattern with genetic transmission

The facial motor system

Facial movements support a variety of functions in human behavior. They participate in automatic somatic and visceral motor programs, they are essential in producing communicative displays of affective states and they are also subject to voluntary control. The multiplicity of functions of facial muscles, compared to limb muscles, is reflected in the heterogeneity of their anatomical and histological characteristics that goes well beyond the conventional classification in single facial muscles. Such parcellation in different functional muscular units is maintained throughout the central representation of facial movements from the brainstem up to the neocortex. Facial movements peculiarly lack a conventional proprioceptive feedback system, which is only in part vicariated by cutaneous or auditory afferents. Facial motor activity is the main marker of endogenous affective states and of the affective valence of external stimuli. At the cortical level, a complex network of specialized motor areas supports voluntary facial movements and, differently from upper limb movements, in such network there does not seem to be a prime actor in the primary motor cortex. \ua9 2013 Elsevier Ltd