Leishmania manipulation of sand fly feeding behavior results in enhanced transmission.

In nature the prevalence of Leishmania infection in whole sand fly populations can be very low (<0.1%), even in areas of endemicity and high transmission. It has long since been assumed that the protozoan parasite Leishmania can manipulate the feeding behavior of its sand fly vector, thus enhancing transmission efficiency, but neither the way in which it does so nor the mechanisms behind such manipulation have been described. A key feature of parasite development in the sand fly gut is the secretion of a gel-like plug composed of filamentous proteophosphoglycan. Using both experimental and natural parasite-sand fly combinations we show that secretion of this gel is accompanied by differentiation of mammal-infective transmission stages. Further, Leishmania infection specifically causes an increase in vector biting persistence on mice (re-feeding after interruption) and also promotes feeding on multiple hosts. Both of these aspects of vector behavior were found to be finely tuned to the differentiation of parasite transmission stages in the sand fly gut. By experimentally accelerating the development rate of the parasites, we showed that Leishmania can optimize its transmission by inducing increased biting persistence only when infective stages are present. This crucial adaptive manipulation resulted in enhanced infection of experimental hosts. Thus, we demonstrate that behavioral manipulation of the infected vector provides a selective advantage to the parasite by significantly increasing transmission

Solutions of the boundary Yang-Baxter equation for ADE models

We present the general diagonal and, in some cases, non-diagonal solutions of the boundary Yang-Baxter equation for a number of related interaction-round-a-face models, including the standard and dilute A_L, D_L and E_{6,7,8} models.Comment: 32 pages. Sections 7.2 and 9.2 revise

Evidence for Circumburst Extinction of Gamma-Ray Bursts with Dark Optical Afterglows and Evidence for a Molecular Cloud Origin of Gamma-Ray Bursts

First, we show that the gamma-ray bursts with dark optical afterglows (DOAs) cannot be explained by a failure to image deeply enough quickly enough, and argue that circumburst extinction is the most likely solution. If so, many DOAs will be ``revived'' with rapid follow up and NIR searches in the HETE-2 and Swift eras. Next, we consider the effects of dust sublimation and fragmentation, and show that DOAs occur in clouds of size R > 10L_{49}^{1/2} pc and mass M > 3x10^5L_{49} M_{sun}, where L is the luminosity of the optical flash. Stability considerations show that such clouds cannot be diffuse, but must be molecular. Consequently, we compute the expected column density distribution of bursts that occur in Galactic-like molecular clouds, and show that the column density measurements from X-ray spectra of afterglows, DOAs and otherwise, satisfy this expectation in the source frame.Comment: Invited Review. To appear in Procs. of Gamma-Ray Burst and Afterglow Astronomy 2001: A Workshop Celebrating the First Year of the HETE Mission, 8 pages, 8 figures, LaTe

Interstellar Ti II in the Milky Way and Magellanic Clouds

We discuss several sets of Ti II absorption-line data, which probe a variety of interstellar environments in our Galaxy and in the Magellanic Clouds. Comparisons of high-resolution (FWHM ~ 1.3-1.5 km/s) Ti II spectra of Galactic targets with corresponding high-resolution spectra of Na I, K I, and Ca II reveal both similarities and differences in the detailed structure of the absorption-line profiles -- reflecting component-to-component differences in the ionization and depletion behaviour of those species. Moderate-resolution (FWHM ~ 3.4-4.5 km/s) spectra of more heavily reddened Galactic stars provide more extensive information on the titanium depletion in colder, denser clouds -- where more than 99.9 per cent of the Ti may be in the dust phase. Moderate-resolution (FWHM ~ 4.5-8.7 km/s) spectra of stars in the Magellanic Clouds suggest that the titanium depletion is generally much less severe in the LMC and SMC than in our Galaxy [for a given N(H_tot), E(B-V), or molecular fraction f(H_2)] -- providing additional evidence for differences in depletion patterns in those two lower-metallicity galaxies. We briefly discuss possible implications of these results for the interpretation of gas-phase abundances in QSO absorption-line systems and of variations in the D/H ratio in the local Galactic ISM.Comment: 56 pages, 26 figures, accepted to MNRA

Wonderful blowups associated to group actions

A group action on a smooth variety provides it with the natural stratification by irreducible components of the fixed point sets of arbitrary subgroups. We show that the corresponding maximal wonderful blowup in the sense of MacPherson-Procesi has only abelian stabilizers. The result is inspired by the abelianization algorithm of Batyrev.Comment: 6 page

An Evaluation of the Sustainability of Global Tuna Stocks Relative to Marine Stewardship Council Criteria

The Marine Stewardship Council (MSC) has established a program whereby a fishery may be certified as being sustainable. The sustainability of a fishery is defined by MSC criteria which are embodied in three Principles: relating to the status of the stock, the ecosystem of which the stock is a member and the fishery management system. Since many of these MSC criteria are comparable for global tuna stocks, the MSC scoring system was used to evaluate nineteen stocks of tropical and temperate tunas throughout the world and to evaluate the management systems of the Regional Fishery Management Organizations (RFMO) associated with these stocks