Zeólitas e Yucca schidigera em rações para cães: palatabilidade, digestibilidade e redução de odores fecais Zeolites and Yucca schidigera in commercial ration for dogs: palatability, digestibility and reduction of fecal odors

Objetivou-se com este trabalho determinar a interferência dos aditivos extrato de Yucca schidigera e zeólitas (Clinoptilolita) na palatabilidade e digestibilidade de rações comerciais e avaliar sua capacidade de redução do odor das fezes e melhora da consistência fecal de cães. Utilizaram-se cães adultos da raça Beagle com peso médio de ±12,51 kg em três experimentos, todos em delineamento inteiramente casualizado. No teste de palatabilidade, realizado nos dez dias iniciais, utilizaram-se 16 animais distribuídos em duas dietas (controle, com 1,00% de zeólita; e controle + 375 ppm de Yucca schidigera) e, no teste de redução de odor das fezes, realizado nos seis dias posteriores, utilizaram-se 14 animais distribuídos em sete dietas (uma controle e outras seis, formuladas a partir da dieta controle, porém contendo Yucca schidigera (125, 250 ou 375 ppm) ou zeólitas (0,50; 0,75; ou 1,00%). Essas dietas foram utilizadas também no teste de digestibilidade e escore fecal, realizado com 21 animais durante 20 dias. A inclusão desses aditivos na dieta não prejudica a palatabilidade nem a digestibilidade de matéria seca, proteína bruta, extrato etéreo e energia bruta do alimento fornecido. Os níveis de 0,75% e 1,0% de zeólitas reduz significativamente o odor das fezes e aumenta a consistência fecal quando adicionados a rações comerciais para cães.<br>The objective of this study was to determine the interference of extract additives of Yucca schidigera and zeolites (Clinoptilolita) on the palatability and digestibility of commercial rations and to evaluate their capacity for reducing fecal odor and improving of fecal consistency of dogs. It was used Beagle breed adult dogs with average weight of ±12.51 kg in 3 experiments, all of them in a completely randomized design. In the palatability test, performed on the first ten days, it was used 16 animals distributed in two diets (control diet, with 1.00% zeolite and control diet + 375 ppm Yucca schidigera) and, on reduction of fecal odor test, performed on the six following days, it was used 14 animals distributed in seven diets (one control and the other six formulated from control diet, containing Yucca schidigera (125, 250 or 375 ppm) or zeolites (0.50; 0.75 or 100%, however). These diets were also used in the digestibility and fecal score trials performed with 21 animals during 20 days. The inclusion of these aditivies in the diet does not harm the palatability neither digestibility of dry matter, crude protein, ether extract and gross energy of the supplied food. Levels of 0.75% and 1.0% of zeolites significantly reduce odor of feces and increase fecal consistency when added to commercial rations for dogs

Increasing levels of zeolite and Yucca schidigera in diets for adult cats

The effect of the additives Yucca schidigera (YSC) and zeolite (clinoptilolite) on digestibility, fecal texture and odor, blood parameters and urine pH of domesticated felines was evaluated. The experiment was conducted in a randomized block design, with twenty-one cats, in two periods, distributed in seven treatments: moist commercial feed (control); control + 125, 250 and 375 ppm YSC; and control + 0.5; 0.75 and 1.0 % zeolite. No differences were observed between the diets regarding apparent digestibility coefficients of nutrient, energy, urine pH or blood parameters. However, levels of 0.5 and 0.75% zeolite were effective both in reducing odor (R² = 96.39) and for fecal texture (R² = 99.63), showing a quadratic pattern for these variables. Levels of 125 and 375 ppm YSC were also efficient in reducing fecal odor; however they did not adjust to regression. Levels of 0.5% and 0.75% zeolite significantly reduce odor of feces and increase fecal texture when added to commercial feed for cats

Safety and efficacy of non-steroidal anti-inflammatory drugs to reduce ileus after colorectal surgery

Background: Ileus is common after elective colorectal surgery, and is associated with increased adverse events and prolonged hospital stay. The aim was to assess the role of non-steroidal anti-inflammatory drugs (NSAIDs) for reducing ileus after surgery. Methods: A prospective multicentre cohort study was delivered by an international, student- and trainee-led collaborative group. Adult patients undergoing elective colorectal resection between January and April 2018 were included. The primary outcome was time to gastrointestinal recovery, measured using a composite measure of bowel function and tolerance to oral intake. The impact of NSAIDs was explored using Cox regression analyses, including the results of a centre-specific survey of compliance to enhanced recovery principles. Secondary safety outcomes included anastomotic leak rate and acute kidney injury. Results: A total of 4164 patients were included, with a median age of 68 (i.q.r. 57\u201375) years (54\ub79 per cent men). Some 1153 (27\ub77 per cent) received NSAIDs on postoperative days 1\u20133, of whom 1061 (92\ub70 per cent) received non-selective cyclo-oxygenase inhibitors. After adjustment for baseline differences, the mean time to gastrointestinal recovery did not differ significantly between patients who received NSAIDs and those who did not (4\ub76 versus 4\ub78 days; hazard ratio 1\ub704, 95 per cent c.i. 0\ub796 to 1\ub712; P = 0\ub7360). There were no significant differences in anastomotic leak rate (5\ub74 versus 4\ub76 per cent; P = 0\ub7349) or acute kidney injury (14\ub73 versus 13\ub78 per cent; P = 0\ub7666) between the groups. Significantly fewer patients receiving NSAIDs required strong opioid analgesia (35\ub73 versus 56\ub77 per cent; P &lt; 0\ub7001). Conclusion: NSAIDs did not reduce the time for gastrointestinal recovery after colorectal surgery, but they were safe and associated with reduced postoperative opioid requirement