Weight estimation techniques for composite airplanes in general aviation industry

Currently available weight estimation methods for general aviation airplanes were investigated. New equations with explicit material properties were developed for the weight estimation of aircraft components such as wing, fuselage and empennage. Regression analysis was applied to the basic equations for a data base of twelve airplanes to determine the coefficients. The resulting equations can be used to predict the component weights of either metallic or composite airplanes

(E)-3-Phenyl-2-(1-tosyl-1H-indol-3-ylcarbon­yl)acrylonitrile

In the title compound, C25H18N2O3S, the indole moiety is planar and makes a dihedral angle of 89.95 (09)° with the phenyl ring of the sulfonyl substituent. The mol­ecular conformation features a weak C—H⋯N short contact and the crystal packing reveals a weak C—H⋯O hydrogen bond

Crystal structure of 2-methylamino-3-nitro-4-p-tolylpyrano[3,2-c]chromen-5(4H)-one

The authors thank Dr Babu Varghese, SAIF, IIT, Chennai, India, for the data collection.Peer reviewedPublisher PD

OPTIMAL ALLOCATION OF TCSC DEVICES FOR THE ENHANCEMENT OF ATC IN DEREGULATED POWER SYSTEM USING FLOWER POLLINATION ALGORITHM

This paper proposes a best possible distribution of Thyristor Controlled Series Compensator (TCSC) to progress the Available Transfer Capability (ATC) of power transactions between sources and sink areas in the deregulated power system. The principle of TCSC device is to balance the inductive voltage drop in the line by an introduced capacitive voltage or in other words to alleviate the effective reactance of the transmission line to improve ATC in the network. The objective of the optimization is to find the preeminent location and parameters of TCSC devices by means of Flower Pollination Algorithm (FPA) for maximizing ATC and minimizing power losses and installation cost of TCSC device. The estimate of ATC using AC Power Transfer Distribution Factors (ACPTDF) based on the Newton Raphson power flow technique. The ACPTDFs are the consequent using sensitivity based approach for the system intact case and utilized to check the line flow limits during ATC fortitude. The efficacy of the proposed method is demonstrated using an IEEE-30 bus test system for the evaluation of ATC in normal and line outage contingencies conditions for the preferred bilateral, multilateral and area wise transactions. The simulation outcome illustrates that the introduction of TCSC devices in an accurate location could increase ATC, fall in total losses and advance the line congestion as compared to the system without TCSC devices

rac-Diethyl 5-oxo-2-[(2,4,4-trimethyl­pentan-2-yl)amino]-4,5-dihydro­pyrano[3,2-c]chromene-3,4-dicarboxyl­ate

The title compound, C26H33NO7, comprises a racemic mixture of asymmetric mol­ecules containing one stereogenic centre. The dihedral angle between the mean planes of the fused pyran ring and the coumarin ring system is 8.12 (14)°. The mol­ecular structure features a short N—H⋯O contact, which generates an S(6) ring motif. The crystal packing are stabilized by C—H⋯O inter­actions

rac-Dimethyl 2-(tert-butyl­amino)-5-oxo-4,5-dihydro­pyrano[3,2-c]chromene-3,4-dicarboxyl­ate

The title compound, C20H21NO7, is asymmetric with a chiral centre located in the pyran ring and crystallizes as a racemate. The mol­ecular framework is somewhat bent; the coumarin moiety and the pyran ring are inclined by 7.85 (5)°. The mol­ecular structure is characterized by an intra­molecular N—H⋯O hydrogen bond, which generates an S(6) ring motif, and the crystal packing is stabilized by inter­molecular C—H⋯O hydrogen bonds. The 3-carboxyl­ate O atom is involved in both of them, having a bifurcated character

2-Iodo-3-(4-meth­oxy­anilino)-5,5-dimethyl­cyclo­hex-2-en-1-one

The cyclo­hexene ring in the title compound, C15H18INO2, adopts a sofa conformation. The dihedral angle between the cyclo­hexene (through all ring atoms) and benzene rings is 63.3 (1)°. The mol­ecular conformation features an N—H⋯I short contact and the crystal packing features C—H⋯O hydrogen bonds

Angelman Syndrome Protein UBE3A Interacts with Primary Microcephaly Protein ASPM, Localizes to Centrosomes and Regulates Chromosome Segregation

Many proteins associated with the phenotype microcephaly have been localized to the centrosome or linked to it functionally. All the seven autosomal recessive primary microcephaly (MCPH) proteins localize at the centrosome. Microcephalic osteodysplastic primordial dwarfism type II protein PCNT and Seckel syndrome (also characterized by severe microcephaly) protein ATR are also centrosomal proteins. All of the above findings show the importance of centrosomal proteins as the key players in neurogenesis and brain development. However, the exact mechanism as to how the loss-of-function of these proteins leads to microcephaly remains to be elucidated. To gain insight into the function of the most commonly mutated MCPH gene ASPM, we used the yeast two-hybrid technique to screen a human fetal brain cDNA library with an ASPM bait. The analysis identified Angelman syndrome gene product UBE3A as an ASPM interactor. Like ASPM, UBE3A also localizes to the centrosome. The identification of UBE3A as an ASPM interactor is not surprising as more than 80% of Angelman syndrome patients have microcephaly. However, unlike in MCPH, microcephaly is postnatal in Angelman syndrome patients. Our results show that UBE3A is a cell cycle regulated protein and its level peaks in mitosis. The shRNA knockdown of UBE3A in HEK293 cells led to many mitotic abnormalities including chromosome missegregation, abnormal cytokinesis and apoptosis. Thus our study links Angelman syndrome protein UBE3A to ASPM, centrosome and mitosis for the first time. We suggest that a defective chromosome segregation mechanism is responsible for the development of microcephaly in Angelman syndrome

Towards Visible Light Hydrogen Generation: Quantum Dot-Sensitization via Efficient Light Harvesting of Hybrid-TiO2

We report pronounced enhancement of photoelectrochemical hydrogen generation of a quantum dot-sensitized hybrid-TiO2 (QD/H-TiO2) electrode that is composed of a mesoporous TiO2 layer sandwiched by a double sided energy harvesting layer consisting of a surface-textured TiO2 inverse opals layer on the bottom and a patterned mesoporous TiO2 layer on the top. CdSe/H-TiO2 exhibits a maximum photocurrent density of similar to 16.2 mA/cm(2), which is 35% higher than that of the optimized control sample (CdSe/P25), achieved by matching of the bandgap of quantum dot-sensitization with the wavelength where light harvesting of H-TiO2 is observed. Furthermore, CdSe/H-TiO2 under filtered exposure conditions recorded current density of similar to 14.2 mA/cm(2), the greatest value in the visible range. The excellent performance of the quantum dot-sensitized H-TiO2 suggests that alteration of the photoelectrodes to suitable nanostructures with excellent light absorption may offer optimal strategies for attaining maximum efficiency in a variety of photoconversion systems.open3