A clinical case of intricate tracheal disease and asthma

Context: Asthma is the most common inflammatory disease of the airways in children. The term problematic asthma is used to describe children with chronic symptoms or acute severe exacerbations, or both, not responding to standard asthma therapy. Case Presentation: We describe the case of a 5 years old girl with a history of recurrent respiratory infections and asthma since the first months of life, with a poor response to conventional therapies (antibiotics, high dose corticosteroids combined with long-acting β2 agonists and oral leukotriene-receptor antagonists). In some cases she needed hospitalization for the important respiratory engagement and radiological findings of pulmonary consolidations, predominantly localized to the right lung. Computed tomography angiography (CTA), described a mild tracheobronchomalacia caused by the right innominate artery compression and a dense tissue mediastinal extrinsic compression of the main bronchus of the middle lobe, defined a Middle Lobe Syndrome (MLS). Evidence Acquisition: MLS is defined as a recurrent or chronic collapse or infection of the middle lobe of the right lung. There is often a history of multiple treatments with antibiotics and anti-asthmatic drugs for ‘‘recurrent pneumonia’’ or ‘‘asthma’’, as in our patient. Chest X-ray is the first-line diagnostic tool, especially on the lateral view. CT-scan and bronchoscopy are considered useful for diagnosis or treatment. Treatment depends on etiology of MLS. Conclusion: In case of severe asthma symptoms co-morbidities must be evaluated. MLS is frequently unrecognized in children and thinking of it is a prerequisite for diagnosis, especially when recurrent respiratory infections or asthma symptoms are predominantly localized to the right lung

Head–neck melanoma: Clinical, histopathological and prognostic features of an Italian multicentric study

factor. As regards the scalp, some studies indicate a particularly aggressive biological behaviour for this anatomical localisation. Objectives: In this multicentric study, data regarding head–neck melanoma (HNM) have been revised. Methods: The design of the study included two main phases. In this retrospective study, data regarding HNM have been collected and analysed. Results: In summary, our data suggest that the posterior neck is the area most affected by thicker melanomas. Cheeks and neck melanoma are associated with reduced disease‐free years of life and overall survival compared with all other sites of HNM. Conclusions: This study provides useful information in defining the clinical features of HNM, thus improving diagnosis and treatment strategies

Head–neck melanoma: Clinical, histopathological and prognostic features of an Italian multicentric study

BackgroundPrimitive location of melanoma could be a relevant prognostic factor. As regards the scalp, some studies indicate a particularly aggressive biological behaviour for this anatomical localisation.ObjectivesIn this multicentric study, data regarding head-neck melanoma (HNM) have been revised.MethodsThe design of the study included two main phases. In this retrospective study, data regarding HNM have been collected and analysed.ResultsIn summary, our data suggest that the posterior neck is the area most affected by thicker melanomas. Cheeks and neck melanoma are associated with reduced disease-free years of life and overall survival compared with all other sites of HNM.ConclusionsThis study provides useful information in defining the clinical features of HNM, thus improving diagnosis and treatment strategies.Primitive location of melanoma could be a relevant prognostic factor. In this multicentric study, data regarding head-neck melanoma (HNM) have been revised.Our data suggest that posterior neck is the area most affected by thicker melanomas. Cheeks and neck melanoma are associated with reduced disease-free years of life and overall survival compared with all other sites of HNM.This study provides useful information in defining the clinical features of HNM, thus improving diagnosis and treatment strategies. imag

Angiolymphoid hyperplasia with eosinophilia

[No abstract available

Allergopatie cutanee da nichel

Su un campione di 979 soggetti osservati per un anno presso un ambulatorio dermoaallergologico, sono stati analizzati i dati emersi dal protocollo applicato, comprensivo di: visita allergologica preceduta da anamnesi sintomatologia e lavorativa, patch test nei soggetti con sospetta dermatite allergica utilizzando la serie standard dell' ICDRG e, dopo 15 giorni, le serie lavorative specifiche I risultati hanno evidenziato che responsabile di oltre la metà delle positività ai patch test (54,3%) è risultato il nichel. Nel 35,8% delle positività si trattava di sensibilità solo al nichel, mentre nel 18,5% di polisensibilizzazion