Daily Dietary Nutrition and Nutraceutical Intake in Agricultural Laborers of Hirakud Command Area, Sambalpur, Odisha, India

Sambalpur is considered as the rice bowl of Odisha for its cultivation activities due to the presence of hydroelectric power house Hirakud Dam, with total capacity of  5,896,000,000 m3, 55 km long and is one of the first major multipurpose river valley projects started after India's independence. It irrigates about 75,000 km2 (19×106 acres) of land and therefore, is considered as a blessing to the farmer families. As because of cultivation and allied activities, Agricultural Laborers (ALs) constitute a large portion of the active work force. Study on the nutritional intake in this important fraction of population is lacking. Present study was an attempt to know the food consumption pattern and nutritional intakes of ALs in Hirakud command area of Sambalpur district, India. Data were collected from 300 ALs, consisting of 150 from each gender. Daily dietary pattern and nutritional intake of respondent were calculated through 24 hours dietary recall method. It was observed that ALs consume all most all the food varieties available in Odisha. Cereal consumption was 6.80 and 1.77 % excess than the recommend value dietary allowance (RDA) by Indian Council for Medical Research (ICMR, in 1990). Except cereals, all other food consumption was below the RDA value in ALs. The intake of other food varieties in ALs was > 60% deficit from the RDA values. Consumption of milk was 97% less in case of male ALs and 98 % less in case of female ALs in comparison to the values suggested in RDA. Similarly, consumption of all nutrients was less than RDA norms except Vitamin -C in case of male ALs. The consumption of Niacin and Vitamin -C was excess in case of female ALs. Alternate low cost food supply is suggested to compensate such insufficient nutritional uptake by ALs in the study area. Keywords: Food, nutrient intake, nutraceuticals, nutritional status, 24 hours recall metho

Positive environmental effects of the coronavirus 2020 episode: a review

The outbreak of COVID-19 has made a global catastrophic situation that caused 1,039,406 deaths out of 35,347,404 infections, and it will also cause significant socio-economic losses with poverty increasing from 17.1 to 25.9%. Although the spreading rate of COVID-19 is very high on October 6, 2020, the death rate is still less than 2.94%. Nonetheless, this review article shows that the lockdown has induced numerous positive impacts on the environment and on energy consumption. For instance, the lockdown has decreased the electricity demand by 30% in Italy, India, Germany, and the USA, and by 12-20% in France, Germany, Spain, India, and the UK. Additionally, the expenditure of the fuel supply has been decreased by 4% in 2020 as compared to the previous years (2012-2019). In particular, The global demand for coal fuel has been reduced by 8% in March and April 2020 as compared to the same time in 2019. In terms of harmful emissions, the lockdowns reduced the emissions of nitrous oxides by 20-30% in China, Italy, France, Spain, and by 77.3% in São Paulo, Brazil. Similarly, the particulate matter level has been reduced from 5-15% in Western Europe, to 200% in New Delhi, India, which in turn has enhanced the air quality in a never-seen manner in recent times. In some places, such as New York, USA, CO2 emission was also reduced by 5-10%. The water quality, in several polluted areas, has also been remarkably enhanced, for example, the dissolved oxygen content in the Ganga River, India, has increased by about 80%. Traffic congestion has also been reduced worldwide, and in some areas, it has been reduced by 50%, such as New York and Los Angeles, USA. Overall, while the COVID-19 pandemic has shrinked the global economy by 13-32%, the pandemic has also clearly benefited to other sectors, which must be considered as the spotlight for the permanent revival of the global ecosystem. Keywords: Air pollution; COVID-19 benefits; Environmental regeneration; Renewable energy; Surface water; Traffic congestion

Infection, Transmission, Pathogenesis and Vaccine Development against Mycoplasma gallisepticum

Mycoplasma sp. comprises cell wall-less bacteria with reduced genome size and can infect mammals, reptiles, birds, and plants. Avian mycoplasmosis, particularly in chickens, is primarily caused by Mycoplasma gallisepticum (MG) and Mycoplasma synoviae. It causes infection and pathology mainly in the respiratory, reproductive, and musculoskeletal systems. MG is the most widely distributed pathogenic avian mycoplasma with a wide range of host susceptibility and virulence. MG is transmitted both by horizontal and vertical routes. MG infection induces innate, cellular, mucosal, and adaptive immune responses in the host. Macrophages aid in phagocytosis and clearance, and B and T cells play critical roles in the clearance and prevention of MG. The virulent factors of MG are adhesion proteins, lipoproteins, heat shock proteins, and antigenic variation proteins, all of which play pivotal roles in host cell entry and pathogenesis. Prevention of MG relies on farm and flock biosecurity, management strategies, early diagnosis, use of antimicrobials, and vaccination. This review summarizes the vital pathogenic mechanisms underlying MG infection and recapitulates the virulence factors of MG-host cell adhesion, antigenic variation, nutrient transport, and immune evasion. The review also highlights the limitations of current vaccines and the development of innovative future vaccines against MG

A view of Homoeopathy on Musculoskeletal Disorders in Sports Injuries

Musculoskeletal disorders and treatment focus on various aspects of Repetitive Motion Injuries, Repetitive Strain Injuries, Cumulative Trauma Disorders, Occupational Cervico-brachial Disorders, Overuse Syndrome, Regional Musculoskeletal Disorders, Soft Tissue Disorders, Work-Related Musculoskeletal Disorders, Musculoskeletal Disorders. It can be seen in the elderly, arthritis, drug interaction checker, fibromyalgia, living healthy, lupus osteoarthritis, pill identifier, rheumatoid arthritis, sports injuries, etc. Musculoskeletal disorders are among the most common problems in sport injuries resulting loss of mobility and physical independence. Homoeopathic treatment schedule considers disease as a dynamic unit and the derangement of the whole man, expressed through the particular organs of the body, i.e. the ‘whole man’ is primarily diseased and individual organs/parts are only secondarily affected. It distinguishes each entity suffering from various or same diseases as different from others, because individuals are inimitable by virtue of their particular and peculiar mental and physical states, and characteristics. Concisely, it lays emphasis on, the ‘person diagnosis’, instead of the ‘disease diagnosis’. Therefore,” every diseases has a cure” is the believe of homoeopathy. Under this flow of homeopathy principle, the aim of this article is to present some of the most frequent musculoskeletal disorders in sports Injuries and their homoeopathic treatment schedule .Sports is an essential part of each nation. There are many ways to classify sports injuries based on the time taken for the tissues to become injured, tissue type affected, severity of the injury, and type of the injury occurred in the individual. Therefore, different homeopathic treatments are required to tackle different category of injury especially the outcomes of sport activities. Keywords: Acute injuries, homoeopathy, overuse injuries, prevention, sports injuries, treatment

Importance of Diet/Nutrition and Regimen in Homoeopathic Treatment

Homoeopathy is a safe and natural form of medicine, based on the principle of “Similia Similibus Curenter”. It means “like is cured by like” i.e. a disease may be cured by something that can cause similar symptoms. Homoeopathy is concerned with treating the whole person rather than the illness alone. The homeopathic remedy selected will be based on all the symptoms of the patient including physical, mental and emotional states as well as past history, family history, and intrauterine history of the patient.  Homoeopathic remedies stimulate the body's own immune system and offer a long lasting cure rather than giving temporary relief. On the other hand, the action of the homeopathic remedy becomes complete when proper guidance regarding instructions about diet and regimen mentioned by stalwarts of homeopathic physicians are followed. The objective of the present review article is to discuss how diet and regimen also are the key factors for successful treatment of a disease. Therefore, research on the nutritional values of different foods must be evaluated to be used as nutraceutics, besides regimen is also important to treat different disease. Finally, combination of medicine, food (nutrition) and regimen are important for the successful treatment of a disease

Successful treatment of ureteric calculi with constitutional homoeopathic medicine Lycopodium clavatum: A Case report

Introduction Formation of stone in the urinary tract, kidney, ureter and bladder is called as Urolithiasis. Formation of urinary stones is very common. About 5-15% population are affected with urinary stone, and, therefore, causes high morbidity in comparison to the above types of stone formation. Shock wave lithotripsy and ureteroscopy along with conservative treatments are the most common approaches for the treatment of calculi, although considered as expressive in one hand, and on the other hand, such interventions may lead to complications. Therefore, alternative medicines give a second thought for the treatment of urolithiasis because it avoids surgical interventions. Here we present a case study for the successful treatment of urolithiasis by a homoeopathic medicine Lycopodium clavatum in a 43 years old male. Case Profile A 43-year-old male patient with intense pain in the right loin for 5-6 days, increased frequency of urination, ineffectual urination, severe pain during urination, and finally with the pain score was 9, was considered for treatment in the present study. Based on his complete case history, Lycopodium clavatum at potencies of 0/1 to 0/6 was prescribed to him. Conclusion Correct homoeopathic organ specific or constitutional formulation(s) selected based on specific important symptoms can also be efficacious in diseases such as ureteric stone. Constitutional medicine Lycopodium clavatum is usually prescribed when the patient is with right side pain with ureteric stone and it is justified in the present case report. Randomized control trial is suggested to ascertain the results obtained in the present study i.e. successful treatment of urolithiasis with the constitutional homeopathic formulation Lycopodium clavatum

Oxidative stress physiology in Scylla serrata for environmental health assessment

The oxidative stress (OS) condition and antioxidant level as a function of pH, few major elements, temperature, turbidity, organic carbon, sediment, and water salinity are vital to understanding the redox homeostasis of inhabiting animals. These parameters are also used to monitor environmental health. A spatiotemporal redox antioxidant system, followed by discriminant function analysis about the aforementioned abiotic factors, was investigated in the muscle, gill, and hepatopancreas of the mud crab, Scylla serrata, sampled from the Indian coastal belt along the Bay of Bengal (Tamil Nadu and Odisha) and the Arabian Sea (Gujarat) as a measure of environmental health assessment. Results revealed that the redox homeostasis of mud crabs significantly varied with seasonal fluctuations of abiotic factors and sediment chemistry. The level of superoxide dismutase and the non-protein-SH group were negatively correlated, whereas other antioxidant molecules with lipid peroxidation levels were positively correlated with abiotic factors. Only the activities of glutathione peroxidase and glutathione reductase were strongly correlated with all the abiotic factors. The hepatopancreas was found to be the most susceptible organ to OS. The lipid peroxidation level was 20–25 times higher in hepatopancreatic tissue than that in other tissues. The antioxidant level was elevated to 200% during the summer compared to the rainy season. Thus, the results of redox homeostasis in S. serrata may be useful for monitoring the ecotoxic effects of estuarine and marine environments and managing the inhabiting species

Oxidative stress, hormones, and effects of natural antioxidants on intestinal inflammation in inflammatory bowel disease

Inflammatory bowel disease (IBD) is a chronic, relapsing gastrointestinal (GI) disorder characterized by intestinal inflammation. The etiology of IBD is multifactorial and results from a complex interplay between mucosal immunity, environmental factors, and host genetics. Future therapeutics for GI disorders, including IBD, that are driven by oxidative stress require a greater understanding of the cellular and molecular mechanisms mediated by reactive oxygen species (ROS). In the GI tract, oxidative stressors include infections and pro-inflammatory responses, which boost ROS generation by promoting the production of pro-inflammatory cytokines. Nuclear factor kappa B (NF-κB) and nuclear factor erythroid 2–related factor 2 (Nrf2) represent two important signaling pathways in intestinal immune cells that regulate numerous physiological processes, including anti-inflammatory and antioxidant activities. Natural antioxidant compounds exhibit ROS scavenging and increase antioxidant defense capacity to inhibit pro-oxidative enzymes, which may be useful in IBD treatment. In this review, we discuss various polyphenolic substances (such as resveratrol, curcumin, quercetin, green tea flavonoids, caffeic acid phenethyl ester, luteolin, xanthohumol, genistein, alpinetin, proanthocyanidins, anthocyanins, silymarin), phenolic compounds including thymol, alkaloids such as berberine, storage polysaccharides such as tamarind xyloglucan, and other phytochemicals represented by isothiocyanate sulforaphane and food/spices (such as ginger, flaxseed oil), as well as antioxidant hormones like melatonin that target cellular signaling pathways to reduce intestinal inflammation occurring with IBD

Wastewater Based Epidemiology Perspective as a Faster Protocol for Detecting Coronavirus RNA in Human Populations: A Review with Specific Reference to SARS-CoV-2 Virus

Abstract: Wastewater-based epidemiology (WBE) has a long history of identifying a variety of viruses from poliovirus to coronaviruses, including novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The presence and detection of SARS-CoV-2 in human feces and its passage into the water bodies are significant public health challenges. Hence, the hot issue of WBE of SARS-CoV-2 in the coronavirus respiratory disease (COVID-19) pandemic is a matter of utmost importance (e.g., SARS-CoV-1). The present review discusses the background, state of the art, actual status, and prospects of WBE, as well as the detection and quantification protocols of SARS-CoV-2 in wastewater. The SARS-CoV-2 detection studies have been performed in different water matrixes such as influent and effluent of wastewater treatment plants, suburban pumping stations, hospital wastewater, and sewer networks around the globe except for Antarctica. The findings revealed that all WBE studies were in accordance with clinical and epidemiological data, which correlates the presence of SARS-CoV-2 ribonucleic acid (RNA) with the number of new daily positive cases officially reported. This last was confirmed via Reverse Transcriptase-quantitative Polymerase Chain Reaction (RT-qPCR) testing which unfortunately is not suitable for real-time surveillance. In addition, WBE concept may act as a faster protocol to alert the public health authorities to take administrative orders (possible re-emerging infections) due to the impracticality of testing all citizens in a short time with limited diagnostic facilities. A comprehensive and integrated review covering all steps starting from sampling to molecular detection of SARS-CoV-2 in wastewater has been made to guide for the development well-defined and reliable protocols

Recent trends in the nanozeolites-based oxygen concentrators and their application in respiratory disorders

Medical-grade oxygen is the basic need for all medical complications, especially in respiratory-based discomforts. There was a drastic increase in the demand for medical-grade oxygen during the current pandemic. The non-availability of medical-grade oxygen led to several complications, including death. The oxygen concentrator was only the last hope for the patient during COVID-19 pandemic around the globe. The demands also are everlasting during other microbial respiratory infections. The yield of oxygen using conventional molecular zeolites in the traditional oxygen concentrator process is less than the yield noticed when its nano-form is used. Nanotechnology has enlightened hope for the efficient production of oxygen by such oxygen concentrators. Here in the current review work, the authors have highlighted the basic structural features of oxygen concentrators along with the current working principle. Besides, it has been tried to bridge the gap between conventional oxygen concentrators and advanced ones by using nanotechnology. Nanoparticles being usually within 100 nm in size have a high surface area to volume ratio, which makes them suitable adsorbents for oxygen. Here authors have suggested the use of nano zeolite in place of molecular zeolites in the oxygen concentrator for efficient delivery of oxygen by the oxygen concentrators