The impact of age, sex and socioeconomic deprivation on outcomes in a colorectal cancer screening programme

<p>Background: Population-based colorectal cancer screening has been shown to reduce cancer specific mortality and is used across the UK. Despite evidence that older age, male sex and deprivation are associated with an increased incidence of colorectal cancer, uptake of bowel cancer screening varies across demographic groups. The aim of this study was to assess the impact of age, sex and deprivation on outcomes throughout the screening process.</p> <p>Methods: A prospectively maintained database, encompassing the first screening round of a faecal occult blood test screening programme in a single geographical area, was analysed.</p> <p>Results: Overall, 395 096 individuals were invited to screening, 204 139 (52%) participated and 6 079 (3%) tested positive. Of the positive tests, 4 625 (76%) attended for colonoscopy and cancer was detected in 396 individuals (9%). Lower uptake of screening was associated with younger age, male sex and deprivation (all p<0.001). Only deprivation was associated with failure to proceed to colonoscopy following a positive test (p<0.001). Despite higher positivity rates in those that were more deprived (p<0.001), the likelihood of detecting cancer in those attending for colonoscopy was lower (8% most deprived vs 10% least deprived, p = 0.003).</p> <p>Conclusion: Individuals who are deprived are less likely to participate in screening, less likely to undergo colonoscopy and less likely to have cancer identified as a result of a positive test. Therefore, this study suggests that strategies aimed at improving participation of deprived individuals in colorectal cancer screening should be directed at all stages of the screening process and not just uptake of the test.</p&gt

Microstructural characterisation of biocompatible sol-gel derived vanadium doped TiO2 on Ti substrates

Sol-gel derived pure titania is compared with vanadium and / or aluminium modified titania deposited by spin coating on pure titanium substrates annealed at 300C and 650C. Reflection high-energy electron diffraction indicated the presence of anatase from the surface layers of samples annealed at 300C with a transition to rutile with increasing annealing temperature and addition of vanadium. Cross-sectional transmission electron microscopy indicated a gradation of Ti-O phases through the layer with the dominant presence of rutile. Aluminium was found to inhibit grain growth while vanadium promoted crystallisation

Quantitative changes in soil C over 17 years under minimum tillage, well fertilized crop rotations in the Brown Soil Zone

Non-Peer Reviewe

Rational foundation of GR in terms of statistical mechanic in the AdS/CFT framework

In this article, we work out the microscopic statistical foundation of the supergravity description of the simplest 1/2 BPS sector in the AdS(5)/CFT(4). Then, all the corresponding supergravity observables are related to thermodynamical observables, and General Relativity is understood as a mean-field theory. In particular, and as an example, the Superstar is studied and its thermodynamical properties clarified.Comment: 13 pages, 6 eps figures, latex, some improvements introduced, reference added, typos correcte

From Gravitons to Giants

We discuss exact quantization of gravitational fluctuations in the half-BPS sector around AdS$_5 \times$S$^5$ background, using the dual super Yang-Mills theory. For this purpose we employ the recently developed techniques for exact bosonization of a finite number $N$ of fermions in terms of $N$ bosonic oscillators. An exact computation of the three-point correlation function of gravitons for finite $N$ shows that they become strongly coupled at sufficiently high energies, with an interaction that grows exponentially in $N$. We show that even at such high energies a description of the bulk physics in terms of weakly interacting particles can be constructed. The single particle states providing such a description are created by our bosonic oscillators or equivalently these are the multi-graviton states corresponding to the so-called Schur polynomials. Both represent single giant graviton states in the bulk. Multi-particle states corresponding to multi-giant gravitons are, however, different, since interactions among our bosons vanish identically, while the Schur polynomials are weakly interacting at high enough energies.Comment: v2-references added, minor changes and typos corrected; 24 pages, latex, 3 epsf figure

Ordering and finite-size effects in the dynamics of one-dimensional transient patterns

We introduce and analyze a general one-dimensional model for the description of transient patterns which occur in the evolution between two spatially homogeneous states. This phenomenon occurs, for example, during the Freedericksz transition in nematic liquid crystals.The dynamics leads to the emergence of finite domains which are locally periodic and independent of each other. This picture is substantiated by a finite-size scaling law for the structure factor. The mechanism of evolution towards the final homogeneous state is by local roll destruction and associated reduction of local wavenumber. The scaling law breaks down for systems of size comparable to the size of the locally periodic domains. For systems of this size or smaller, an apparent nonlinear selection of a global wavelength holds, giving rise to long lived periodic configurations which do not occur for large systems. We also make explicit the unsuitability of a description of transient pattern dynamics in terms of a few Fourier mode amplitudes, even for small systems with a few linearly unstable modes.Comment: 18 pages (REVTEX) + 10 postscript figures appende

Semi-classical Probe Strings on Giant Gravitons Backgrounds

In the first part of this paper we study two $Z_2$ symmetries of the LLM metric, both of which exchange black and white regions. One of them which can be interpreted as the particle-hole symmetry is the symmetry of the whole supergravity solution while the second one is just the symmetry of the metric and changes the sign of the fivefrom flux. In the second part of the paper we use closed string probes and their semi-classical analysis to compare the two 1/2 BPS deformations of $AdS_5\times S^5$, the smooth LLM geometry which contains localized giant gravitons and the superstar case which is a solution with naked singularity corresponding to smeared giants. We discuss the realization of the $Z_2$ symmetry in the semi-classical closed string probes point of view.Comment: 29 pages, 6 .eps figures; v2: References adde

Extended Fermion Representation of Multi-Charge 1/2-BPS Operators in AdS/CFT -- Towards Field Theory of D-Branes --

We extend the fermion representation of single-charge 1/2-BPS operators in the four-dimensional N=4 super Yang-Mills theory to general (multi-charge) 1/2-BPS operators such that all six directions of scalar fields play roles on an equal footing. This enables us to construct a field-theorectic representation for a second-quantized system of spherical D3-branes in the 1/2-BPS sector. The Fock space of D3-branes is characterized by a novel exclusion principle (called `Dexclusion' principle), and also by a nonlocality which is consistent with the spacetime uncertainty relation. The Dexclusion principle is realized by composites of two operators, obeying the usual canonical anticommutation relation and the Cuntz algebra, respectively. The nonlocality appears as a consequence of a superselction rule associated with a symmetry which is related to the scale invariance of the super Yang-Mills theory. The entropy of the so-called superstars, with multiple charges, which have been proposed to be geometries corresponding to the condensation of giant gravitons is discussed from our viewpoint and is argued to be consistent with the Dexclusion principle. Our construction may be regarded as a first step towards a possible new framework of general D-brane field theory.Comment: 43 pages, 4 figures; version 2, corrected typos and added reference

Templates for Convex Cone Problems with Applications to Sparse Signal Recovery

This paper develops a general framework for solving a variety of convex cone problems that frequently arise in signal processing, machine learning, statistics, and other fields. The approach works as follows: first, determine a conic formulation of the problem; second, determine its dual; third, apply smoothing; and fourth, solve using an optimal first-order method. A merit of this approach is its flexibility: for example, all compressed sensing problems can be solved via this approach. These include models with objective functionals such as the total-variation norm, ||Wx||_1 where W is arbitrary, or a combination thereof. In addition, the paper also introduces a number of technical contributions such as a novel continuation scheme, a novel approach for controlling the step size, and some new results showing that the smooth and unsmoothed problems are sometimes formally equivalent. Combined with our framework, these lead to novel, stable and computationally efficient algorithms. For instance, our general implementation is competitive with state-of-the-art methods for solving intensively studied problems such as the LASSO. Further, numerical experiments show that one can solve the Dantzig selector problem, for which no efficient large-scale solvers exist, in a few hundred iterations. Finally, the paper is accompanied with a software release. This software is not a single, monolithic solver; rather, it is a suite of programs and routines designed to serve as building blocks for constructing complete algorithms.Comment: The TFOCS software is available at http://tfocs.stanford.edu This version has updated reference