Ion-sensing using chemically-modified ISFETs

Synthetic macrocyclic polyether ion receptors are the active components for the selective and sensitive detection of potassium ions in chemical sensors based on modified ISFETs.\ud \ud Covalent chemical anchoring of the sensing membrane to the gate oxide of the ISFET is essential in order to increase the lifetime of the sensor system to more than three months

Smart SU-8 Pillars Implemented in a Microfluidic Bioreactor for Continuous Measurement of Glucose

In this contribution we explore a new and simple approach for immobilizing enzymes like glucose oxidase on SU-8 surfaces to develop a smart substrate integrated in microfluidics. SU-8 is a well known photoresist often used in microfluidic prototyping. Immobilization of enzymes on such substance can open new possibilities in the microfabrication of enzyme biosensors and bioreactors. To demonstrate the consistency of this approach, we describe the design, fabrication and the simple functionalization of a microfluidic bioreactor employing smart SU-8 pillars for continuous amperometric measurement of glucose. The results reveal the possibility of simply binding enzymes on SU-8 surface. Moreover, a significant improvement in the linear response range is observed compared to the previous published amperometric microfluidic glucose sensors

Exact quantum phase model for mesoscopic Josephson junctions

Starting from the two-mode Bose-Hubbard model, we derive an exact version of the standard Mathieu equation governing the wave function of a Josephson junction. For a finite number of particles N, we find an additional cos 2 phi term in the potential. We also find that the inner product in this representation is nonlocal in phi. Our model exhibits phenomena, such as pi oscillations, which are not found in the standard phase model, but have been predicted from Gross-Pitaevskii mean-field theory