Improved antitumor response to isolated limb perfusion with tumor necrosis factor after upregulation of endothelial monocyte-activating polypeptide II in soft tissue sarcoma

BACKGROUND: Experiments with tumor necrosis factor alpha (TNF) in rodents have shown that a high dose can lead to hemorrhagic necrosis in tumors. Endothelial monocyte-activating polypeptide II (EMAP-II) is a novel tumor-derived cytokine, and its expression increases the TNF-1 receptor on tumor endothelium, enhances the induction of tissue factor on tumor endothelial cells, and has an antiangiogenic effect. It has recently been shown that in vivo sensitivity of tumor vasculature to TNF is determined by tumor production of EMAP-II. METHODS: We measured the level of EMAP-II in a TNF-resistant soft tissue sarcoma. We subsequently stabile-transfected this cell line with a retroviral construct containing the EMAP gene. In an extremity perfusion model in tumor-bearing rats, we measured response rates to TNF therapy. RESULTS: Functional EMAP-II production was increased after this transfection. Immunostaining of paraffin-embedded tumor tissue sections in rats showed an overexpression of human EMAP-II. Results of the TNF perfusions in rats suggest that this tumor is more sensitive to TNF therapy. CONCLUSIONS: EMAP-II is produced in various levels. One can increase the sensitivity of tumor for TNF therapy in vivo by upregulating the EMAP-II production. This result leaves an opportunity for enhanced TNF response of tumors in future settings

The Cyborg Astrobiologist: Testing a Novelty-Detection Algorithm on Two Mobile Exploration Systems at Rivas Vaciamadrid in Spain and at the Mars Desert Research Station in Utah

(ABRIDGED) In previous work, two platforms have been developed for testing computer-vision algorithms for robotic planetary exploration (McGuire et al. 2004b,2005; Bartolo et al. 2007). The wearable-computer platform has been tested at geological and astrobiological field sites in Spain (Rivas Vaciamadrid and Riba de Santiuste), and the phone-camera has been tested at a geological field site in Malta. In this work, we (i) apply a Hopfield neural-network algorithm for novelty detection based upon color, (ii) integrate a field-capable digital microscope on the wearable computer platform, (iii) test this novelty detection with the digital microscope at Rivas Vaciamadrid, (iv) develop a Bluetooth communication mode for the phone-camera platform, in order to allow access to a mobile processing computer at the field sites, and (v) test the novelty detection on the Bluetooth-enabled phone-camera connected to a netbook computer at the Mars Desert Research Station in Utah. This systems engineering and field testing have together allowed us to develop a real-time computer-vision system that is capable, for example, of identifying lichens as novel within a series of images acquired in semi-arid desert environments. We acquired sequences of images of geologic outcrops in Utah and Spain consisting of various rock types and colors to test this algorithm. The algorithm robustly recognized previously-observed units by their color, while requiring only a single image or a few images to learn colors as familiar, demonstrating its fast learning capability.Comment: 28 pages, 12 figures, accepted for publication in the International Journal of Astrobiolog

Superconductivity in the Correlated Pyrochlore Cd_2Re_2O_7

We report the observation of superconductivity in high-quality Cd$_2$Re$_2$O$_7$ single crystals with room-temperature pyrochlore structure. Resistivity and ac susceptibility measurements establish an onset transition temperature T$_c^{onset}$ = 1.47 K with transition width $\Delta$T$_c$ = 0.25 K. In applied magnetic field, the resistive transition shows a type-II character, with an approximately linear temperature-dependence of the upper critical field H$_{c2}$. The bulk nature of the superconductivity is confirmed by the specific heat jump with $\Delta$C = 37.9 mJ/mol-K. Using the $\gamma$ value extracted from normal-state specific heat data, we obtain $\Delta$C/$\gamma$T$_c$ = 1.29, close to the weak coupling BCS value. In the normal state, a negative Hall coefficient below 100 K suggests electron-like conduction in this material. The resistivity exhibits a quadratic T-dependence between 2 and 60 K, i.e., $\rho =\rho_0$+AT$^2$, indicative of Fermi-liquid behavior. The values of the Kadowaki-Woods ratio A/$\gamma^2$ and the Wilson ratio are comparable to that for strongly correlated materials.Comment: 4 pages, 5 figure

Random walk on disordered networks

Random walks are studied on disordered cellular networks in 2-and 3-dimensional spaces with arbitrary curvature. The coefficients of the evolution equation are calculated in term of the structural properties of the cellular system. The effects of disorder and space-curvature on the diffusion phenomena are investigated. In disordered systems the mean square displacement displays an enhancement at short time and a lowering at long ones, with respect to the ordered case. The asymptotic expression for the diffusion equation on hyperbolic cellular systems relates random walk on curved lattices to hyperbolic Brownian motion.Comment: 10 Pages, 3 Postscript figure

High Energy QCD: Stringy Picture from Hidden Integrability

We discuss the stringy properties of high-energy QCD using its hidden integrability in the Regge limit and on the light-cone. It is shown that multi-colour QCD in the Regge limit belongs to the same universality class as superconformal $\cal{N}$=2 SUSY YM with $N_f=2N_c$ at the strong coupling orbifold point. The analogy with integrable structure governing the low energy sector of $\cal{N}$=2 SUSY gauge theories is used to develop the brane picture for the Regge limit. In this picture the scattering process is described by a single M2 brane wrapped around the spectral curve of the integrable spin chain and unifying hadrons and reggeized gluons involved in the process. New quasiclassical quantization conditions for the complex higher integrals of motion are suggested which are consistent with the $S-$duality of the multi-reggeon spectrum. The derivation of the anomalous dimensions of the lowest twist operators is formulated in terms of the Riemann surfacesComment: 37 pages, 3 figure

Oscillations of a rapidly rotating annular Bose-Einstein condensate

A time-dependent variational Lagrangian analysis based on the Gross-Pitaevskii energy functional serves to study the dynamics of a metastable giant vortex in a rapidly rotating Bose-Einstein condensate. The resulting oscillation frequencies of the core radius reproduce the trends seen in recent experiments [Engels et al., Phys. Rev. Lett. 90, 170405 (2003)], but the theoretical values are smaller by a factor approximately 0.6-0.8.Comment: 7 pages, revtex

Complex Kerr Geometry and Nonstationary Kerr Solutions

In the frame of the Kerr-Schild approach, we consider the complex structure of Kerr geometry which is determined by a complex world line of a complex source. The real Kerr geometry is represented as a real slice of this complex structure. The Kerr geometry is generalized to the nonstationary case when the current geometry is determined by a retarded time and is defined by a retarded-time construction via a given complex world line of source. A general exact solution corresponding to arbitrary motion of a spinning source is obtained. The acceleration of the source is accompanied by a lightlike radiation along the principal null congruence. It generalizes to the rotating case the known Kinnersley class of "photon rocket" solutions.Comment: v.3, revtex, 16 pages, one eps-figure, final version (to appear in PRD), added the relation to twistors and algorithm of numerical computations, English is correcte

Morphologies of AGN host galaxies using HST/ACS in the CDFS-GOODS field

Using HST/ACS images in four bands F435W, F606W, F775W and F850LP, we identify optical counterparts to the X-ray sources in the Chandra Deep Field South in the GOODS South field. A detailed study has been made of these sources to study their morphological types. We use methods like decomposition of galaxy luminosity profiles, color maps and visual inspection of 192 galaxies which are identified as possible optical counterparts of Chandra X-ray sources in the CDFS-GOODS field. We find that most moderate luminosity AGN hosts are bulge dominated in the redshift range (z \approx 0.4-1.3), but not merging/interacting galaxies. This implies probable fueling of the moderate luminosity AGN by mechanisms other than those merger driven.Comment: pdflatex, accepted in ApSS. revisions in tex

Neurocap Use for the Treatment of Iatrogenic Neuropathic Pain: Preliminary Operative Results in 3 Patients

Painful neuromas are a devastating condition that is notoriously difficult to treat. The large number of techniques that have been attempted suggest that no one technique is superior. Neuromas often occur in the extremities, but iatrogenically caused pain in the head and neck area has also been described. This article describes 3 consecutive patients diagnosed with traumatic neuroma who underwent transection of the causative nerve, followed by capping of the nerve stump with a Neurocap. With a follow-up of 7 to 24 months, our results show a marked reduction in the pain scores of all 3 patients. The preliminary results indicate that this technique might be a viable treatment option for patients with a suspected neuroma in the head and neck area