1,691 research outputs found
Outer Regions of the Milky Way
With the start of the Gaia era, the time has come to address the major
challenge of deriving the star formation history and evolution of the disk of
our MilkyWay. Here we review our present knowledge of the outer regions of the
Milky Way disk population. Its stellar content, its structure and its dynamical
and chemical evolution are summarized, focussing on our lack of understanding
both from an observational and a theoretical viewpoint. We describe the
unprecedented data that Gaia and the upcoming ground-based spectroscopic
surveys will provide in the next decade. More in detail, we quantify the expect
accuracy in position, velocity and astrophysical parameters of some of the key
tracers of the stellar populations in the outer Galactic disk. Some insights on
the future capability of these surveys to answer crucial and fundamental issues
are discussed, such as the mechanisms driving the spiral arms and the warp
formation. Our Galaxy, theMilkyWay, is our cosmological laboratory for
understanding the process of formation and evolution of disk galaxies. What we
learn in the next decades will be naturally transferred to the extragalactic
domain.Comment: 22 pages, 10 figures, Invited review, Book chapter in "Outskirts of
Galaxies", Eds. J. H. Knapen, J. C. Lee and A. Gil de Paz, Astrophysics and
Space Science Library, Springer, in pres
Darboux points and integrability of homogeneous Hamiltonian systems with three and more degrees of freedom
We consider natural complex Hamiltonian systems with degrees of freedom
given by a Hamiltonian function which is a sum of the standard kinetic energy
and a homogeneous polynomial potential of degree . The well known
Morales-Ramis theorem gives the strongest known necessary conditions for the
Liouville integrability of such systems. It states that for each there
exists an explicitly known infinite set \scM_k\subset\Q such that if the
system is integrable, then all eigenvalues of the Hessian matrix V''(\vd)
calculated at a non-zero \vd\in\C^n satisfying V'(\vd)=\vd, belong to
\scM_k. The aim of this paper is, among others, to sharpen this result. Under
certain genericity assumption concerning we prove the following fact. For
each and there exists a finite set \scI_{n,k}\subset\scM_k such that
if the system is integrable, then all eigenvalues of the Hessian matrix
V''(\vd) belong to \scI_{n,k}. We give an algorithm which allows to find
sets \scI_{n,k}. We applied this results for the case and we found
all integrable potentials satisfying the genericity assumption. Among them
several are new and they are integrable in a highly non-trivial way. We found
three potentials for which the additional first integrals are of degree 4 and 6
with respect to the momenta.Comment: 54 pages, 1 figur
Nuevo mĂ©todo de preparaciĂłn de soforosa y kojibiosa a partir de 1,6-anhidro-β-D-glucopiranosa
A new method for the preparation of the dissaccharides sophorose and kojibiose by theatment of the 1,6-anhydro-β-D-glucopyranose in DMFHCl 0,03 N under mild conditions is reported.Se describe un nuevo método para la preparación de los disacáridos soforosa y kojibiosa por tratamiento en condiciones suaves de 1,6-anhidro-β-D-glucopiranosa en DMF-HCl 0,03 N
Oligomerización dé aldohexosas en DMF-HCl. Estudio del mecanismo
On the basis of the obtained data for acid catalysed oligomerization reactions of D-glucose, D-galactose, D-manose and L-rhamnose in DMFHCl, mechanistic schemes are proposed.Basándose en los datos obtenidos en reacciones de oligomerización catalizadas por ácidos de D-glucosa, D-galactosa, D-manosa y L-rhamnosa en DMF-HGl se proponen esquemas mecanísticos para cada caso
Analyse de la performance dâadultes cĂ©rĂ©brolĂ©sĂ©s faisant leurs courses dans un supermarchĂ© virtuel
The Proteome of Biologically Active Membrane Vesicles from Piscirickettsia salmonis LF-89 Type Strain Identifies Plasmid-Encoded Putative Toxins
IndexaciĂłn: Scopus.Piscirickettsia salmonis is the predominant bacterial pathogen affecting the Chilean salmonid industry. This bacterium is the etiological agent of piscirickettsiosis, a significant fish disease. Membrane vesicles (MVs) released by P. salmonis deliver several virulence factors to host cells. To improve on existing knowledge for the pathogenicity-associated functions of P. salmonis MVs, we studied the proteome of purified MVs from the P. salmonis LF-89 type strain using multidimensional protein identification technology. Initially, the cytotoxicity of different MV concentration purified from P. salmonis LF-89 was confirmed in an in vivo adult zebrafish infection model. The cumulative mortality of zebrafish injected with MVs showed a dose-dependent pattern. Analyses identified 452 proteins of different subcellular origins; most of them were associated with the cytoplasmic compartment and were mainly related to key functions for pathogen survival. Interestingly, previously unidentified putative virulence-related proteins were identified in P. salmonis MVs, such as outer membrane porin F and hemolysin. Additionally, five amino acid sequences corresponding to the Bordetella pertussis toxin subunit 1 and two amino acid sequences corresponding to the heat-labile enterotoxin alpha chain of Escherichia coli were located in the P. salmonis MV proteome. Curiously, these putative toxins were located in a plasmid region of P. salmonis LF-89. Based on the identified proteins, we propose that the protein composition of P. salmonis LF-89 MVs could reflect total protein characteristics of this P. salmonis type strain. © 2017 Oliver, HernĂĄndez, Tandberg, Valenzuela, Lagos, Haro, SĂĄnchez, Ruiz, Sanhueza-OyarzĂșn, CortĂ©s, Villar, Artigues, Winther-Larsen, Avendaño-Herrera and Yåñez.https://www.frontiersin.org/articles/10.3389/fcimb.2017.00420/ful
Modelling the hydrodynamic conditions associated with Dinophysis blooms in Galicia (NW Spain)
The northwestern Iberian coast (Galician RĂas and shelf) is frequently affected by toxic harmful algal blooms (HABs) (mainly Dinophysis spp.), leading to lengthy harvesting closures in a region where aquaculture has a strong socioeconomic impact. The project ASIMUTH (http://www.asimuth.eu) aimed to develop forecasting capabilities to warn of impending HABs along the European Atlantic coast. Simulations with the ROMS model (hydrodynamical and ecological simulations complemented with Lagrangian particle tracking simulations) of the Galician coastal circulation have been performed in the framework of the ASIMUTH project to characterize and forecast oceanographic conditions before and during HAB periods. In this work, we present the Galician ASIMUTH forecast system and demonstrate its skill in predicting HAB transport and its usefulness to provide assessment for the management of the areas affected by toxic outbreaks. Experience gained during DSP events in 2005 and 2013 is shown. We also describe the Galician pilot HAB bulletins, aimed at distributing forecasts of HAB events that might induce closures of harvesting areas or, when the areas are already closed, at giving information on forthcoming oceanographic conditions that could favour or hamper the opening of an area. Our results show that the model forecasts and the bulletins can provide early warning of the risk of Dinophysis spp. events and the risk of closures linked to the presence of DSP toxins above regulatory levels in harvesting areas.VersiĂłn del editor3,083
A functional BH3 domain in an aquaporin from Leishmania infantum.
Despite the absence of sequences showing significant similarity to any of the members of the Bcl-2 family of proteins in protozoa, experiments carried out in yeast or trypanosomatids have demonstrated that ectopic expression of some of these members alters their response to different death stimuli. Because the BH3 domain is the smallest common signature in all the proteins of this family of apoptosis regulators and also because they are essential for molecular interactions between antagonistic members, we looked for sequences with significant similarity to the BH3 motif in the Leishmania infantum genome. Among the top scoring ones, we found the MYLALQNLGDEV amino-acid stretch at the C terminus of a previously described aquaporin, now renamed as Li-BH3AQP. This motif is highly conserved in homologous proteins from other species of the Leishmania genus. The association of Li-BH3AQP with human Bcl-XL was demonstrated by both co-immunoprecipitation and yeast two-hybrid experiments. Ectopic expression of Li-BH3AQP reduced viability of HeLa cells and this deleterious effect was abrogated by the simultaneous overexpression of Bcl-XL. Although we were not able to demonstrate a reduction in parasite viability when the protein was overexpressed in Leishmania promastigotes, a prodeath effect could be observed when the parasites overexpressing Li-BH3AQP were treated with staurosporine or antimycin A. Surprisingly, these parasites were more resistant, compared with wild-type parasites, to hypotonic stress or nutrient deprivation. The prodeath activity was abolished upon replacement of two highly conserved amino acids in this BH3 domain. Taken together, these results point to Li-BH3AQP as the first non-enzymatic protein ever described in trypanosomatids that is involved in cell death
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