Using schema transformation pathways for data lineage tracing

With the increasing amount and diversity of information available on the Internet, there has been a huge growth in information systems that need to integrate data from distributed, heterogeneous data sources. Tracing the lineage of the integrated data is one of the problems being addressed in data warehousing research. This paper presents a data lineage tracing approach based on schema transformation pathways. Our approach is not limited to one specific data model or query language, and would be useful in any data transformation/integration framework based on sequences of primitive schema transformations

Structural Basis for Catalysis by the Mono- and Dimetalated Forms of the \u3cem\u3edapE\u3c/em\u3e-Encoded \u3cem\u3eN\u3c/em\u3e-succinyl-L,L-Diaminopimelic Acid Desuccinylase

Biosynthesis of lysine and meso-diaminopimelic acid in bacteria provides essential components for protein synthesis and construction of the bacterial peptidoglycan cell wall. The dapE operon enzymes synthesize both meso-diaminopimelic acid and lysine and, therefore, represent potential targets for novel antibacterials. The dapE-encoded N-succinyl-l,l-diaminopimelic acid desuccinylase functions in a late step of the pathway and converts N-succinyl-l,l-diaminopimelic acid to l,l-diaminopimelic acid and succinate. Deletion of the dapE gene is lethal to Helicobacter pylori and Mycobacterium smegmatis, indicating that DapE\u27s are essential for cell growth and proliferation. Since there are no similar pathways in humans, inhibitors that target DapE may have selective toxicity against only bacteria. A major limitation in developing antimicrobial agents that target DapE has been the lack of structural information. Herein, we report the high-resolution X-ray crystal structures of the DapE from Haemophilus influenzae with one and two zinc ions bound in the active site, respectively. These two forms show different activity. Based on these newly determined structures, we propose a revised catalytic mechanism of peptide bond cleavage by DapE enzymes. These structures provide important insight into catalytic mechanism of DapE enzymes as well as a structural foundation that is critical for the rational design of DapE inhibitors

The critical Ising lines of the d=2 Ashkin-Teller model

The universal critical point ratio $Q$ is exploited to determine positions of the critical Ising transition lines on the phase diagram of the Ashkin-Teller (AT) model on the square lattice. A leading-order expansion of the ratio $Q$ in the presence of a non-vanishing thermal field is found from finite-size scaling and the corresponding expression is fitted to the accurate perturbative transfer-matrix data calculations for the $L\times L$ square clusters with $L\leq 9$.Comment: RevTex, 4 pages, two figure