A Study on Proteolytic Enzyme Activity in the Erythrocytes of Diabetic Patients

The present study demonstrates the possibility of increased proteolytic activities in diabetic individuals. Proteolytic activity was measured by the amount of amino group released by the erythrocyte lysate of the diabetic individual using phenylhydrazine treated hemoglobin as substrate. The proteolytic activity in erythrocyte lysates against oxidatively damaged hemoglobin was significantly increased in diabetic individuals compared to controls (p<0.001).The result of this study indicates that in diabetic individuals, proteolytic enzymes degrade many oxidatively altered proteins preventing the accumulation of altered and damaged proteins in the cell

The use of happiness research for public policy

Research on happiness tends to follow a "benevolent dictator" approach where politicians pursue people's happiness. This paper takes an antithetic approach based on the insights of public choice theory. First, we inquire how the results of happiness research may be used to improve the choice of institutions. Second, we show that the policy approach matters for the choice of research questions and the kind of knowledge happiness research aims to provide. Third, we emphasize that there is no shortcut to an optimal policy maximizing some happiness indicator or social welfare function since governments have an incentive to manipulate this indicator

An approach to hygiene education among rural Indian school going children

Objectives: To find out the prevalence of intestinal parasites and its epidemiological correlates among rural Indian school going (6-14 years) children and to study the effect of focused, need based child to child hygiene education on personal hygiene of school children. Materials and Methods: In September 2007, the present participatory action research was undertaken at a feasibly selected village Dhotra (Kasar) in Wardha district of central India. A triangulated research design of quantitative (survey) and qualitative (transect walk & pile sorting) methods was used for the needs assessment before initiating formal hygiene education. Out of enlisted 172 children, data of 118 children with complete information was used for final analysis. The quantitative and qualitative data was entered and analyzed using the Epi Info 6.04 software and Anthropac 4.98.1/X software package respectively. School based participatory life skills based child to child hygiene education was undertaken for message dissemination and behavior change. The effect of this hygiene education on identified key behaviors was assessed after one month Results: Out of the 118 (50 male and 68 female) subjects examined 21 (17.8%, 95%CI, 11.4 – 25.9%) had intestinal parasite infection. The prevalence of intestinal parasitic infection was significantly high among children having dirty untrimmed nails (47.4%, 95%CI, 30.9 – 64.1%) followed by those having poor hand washing practices (37.2%, 95%CI, 22.9 – 53.2%). One month after hygiene education, the proportion of children having practice of hand washing with soap after defecation significantly improved from 63.6 % to 78%. The proportion of clean and cut nails also improved from 67.8% to 80 % (p<0.05). Conclusions: The need based, focused, life skills based child to child hygiene education was effective for behavior change. An integrated approach of drug treatment and focused participatory hygiene education is required to control parasite load among rural Indian school going children

DeWitt-Virasoro construction

We study a particular approach for analyzing worldsheet conformal invariance for bosonic string propagating in a curved background using hamiltonian formalism. We work in the Schrodinger picture of a single particle description of the problem where the particle moves in an infinite-dimensional space. Background independence is maintained in this approach by adopting DeWitt's (Phys.Rev.85:653-661,1952) coordinate independent formulation of quantum mechanics. This enables us to construct certain background independent notion of Virasoro generators, called DeWitt-Virasoro (DWV) generators, and invariant matrix elements of an arbitrary operator constructed out of them in spin-zero representation. We show that the DWV algebra is given by the Witt algebra with additional anomalous terms that vanish for Ricci-flat backgrounds. The actual quantum Virasoro generators should be obtained by first introducing the vacuum state and then normal ordering the DWV generators with respect to that. We demonstrate the procedure in the simple cases of flat and pp-wave backgrounds. This is a shorter version of arXiv:0912.3987 [hep-th] with many technical derivations omitted.Comment: 18 pages, shorter version of arXiv:0912.3987 [hep-th] accepted for publication in Pramana - Journal of Physic

EXAMINING THE INFLUENCE OF EARLY CHILDHOOD EXPERIENCES ON CURRENT EXPRESSIONS OF VERBAL AGGRESSION AND ASSERTIVENESS

The purpose of this study was to find out if there is a relationship between verbal aggression and assertiveness. Specifically, the aim was to establish the extent to which demographic factors, family of origin variables and early life exposure to trauma affects the occurrence of verbal aggression and assertiveness in day to day interactions. Data was collected using an online survey and results from 321 participants were analyzed. Results from the study indicated that age, gender and exposure to verbal aggression have a significant effect on the occurrence of verbal aggression. None of the variables were found to have an effect on the occurrence of Assertiveness. Implications of these are discussed in the results section

Heterotic strings on G_2 orbifolds

We study compactification of heterotic strings to three dimensions on orbifolds of G_2 holonomy. We consider the standard embedding and show that the gauge group is broken from E_8 x E_8 or SO(32) to F_4 x E_8 or SO(25) respectively. We also compute the spectrum of massless states and compare with the results obtained from reduction of the 10-dimensional fields. Non-standard embeddings are discussed briefly. For type II compactifications we verify that IIB and IIA have equal massless spectrum.Comment: LaTex, 21 page

Asymptotic Implied Volatility at the Second Order with Application to the SABR Model

We provide a general method to compute a Taylor expansion in time of implied volatility for stochastic volatility models, using a heat kernel expansion. Beyond the order 0 implied volatility which is already known, we compute the first order correction exactly at all strikes from the scalar coefficient of the heat kernel expansion. Furthermore, the first correction in the heat kernel expansion gives the second order correction for implied volatility, which we also give exactly at all strikes. As an application, we compute this asymptotic expansion at order 2 for the SABR model.Comment: 27 pages; v2: typos fixed and a few notation changes; v3: published version, typos fixed and comments added. in Large Deviations and Asymptotic Methods in Finance, Springer (2015) 37-6

Francis Daniels Moore: one of the brightest minds in the surgical field.

Francis Daniels Moore was a pioneer ahead of his time who made numerous landmark contributions to the field of surgery, including the understanding of metabolic physiology during surgery, liver and kidney transplant, and the famous Study on Surgical Services of the United States (SOSSUS) report of 1975 that served for decades as a guideline for development of surgical residencies. He was the epitome of what a physician should be, a compassionate and dedicated surgeon, innovative scientist, and a medical professional dedicated to quality medical education across all specialties

The Medecins Sans Frontieres Intervention in the Marburg Hemorrhagic Fever Epidemic, Uige, Angola, 2005. I. Lessons Learned in the Hospital.

When the epidemic of Marburg hemorrhagic fever occurred in Uige, Angola, during 2005, the international response included systems of case detection and isolation, community education, the burial of the dead, and disinfection. However, despite large investments of staff and money by the organizations involved, only a fraction of the reported number of cases were isolated, and many cases were detected only after death. This article describes the response of Medecins Sans Frontieres Spain within the provincial hospital in Uige, as well as the lessons they learned during the epidemic. Diagnosis, management of patients, and infection control activities in the hospital are discussed. To improve the acceptability of the response to the host community, psychological and cultural factors need to be considered at all stages of planning and implementation in the isolation ward. More interventional medical care may not only improve survival but also improve acceptability

Trust Over Time in Exchange Relationships: Meta-Analysis and Theory

A common premise in prior research is that trust increases over time in relationships. Through a meta-analysis of 39 studies, we find that the bivariate correlation between trust and relationship duration (1) is on average positive and small, and (2) varies significantly across studies indicating the presence of unobserved moderators. We therefore build a theoretical framework to specify four different mechanisms—initial bias correction, change in relationship value, identification, and trust-based selection—that may affect the development of trust. We then argue that the relative strength of these mechanisms should influence whether trust increases, remains constant, or decreases over time