53 research outputs found
Recommended from our members
Engineered Tumor-Targeted T Cells Mediate Enhanced Anti-Tumor Efficacy Both Directly and through Activation of the Endogenous Immune System.
Chimeric antigen receptor (CAR) T cell therapy has proven clinically beneficial against B cell acute lymphoblastic leukemia and non-Hodgkin's lymphoma. However, suboptimal clinical outcomes have been associated with decreased expansion and persistence of adoptively transferred CAR T cells, antigen-negative relapses, and impairment by an immunosuppressive tumor microenvironment. Improvements in CAR T cell design are required to enhance clinical efficacy, as well as broaden the applicability of this technology. Here, we demonstrate that interleukin-18 (IL-18)-secreting CAR T cells exhibit enhanced in vivo expansion and persistence and significantly increase long-term survival in syngeneic mouse models of both hematological and solid malignancies. In addition, we demonstrate that IL-18-secreting CAR T cells are capable of modulating the tumor microenvironment, as well as enhancing an effective endogenous anti-tumor immune response. IL-18-secreting CAR T cells represent a promising strategy to enhance the clinical outcomes of adoptive T cell therapy
FACTORS AFFECTING SEASONING OF TIMBER USING SAWDUST OPERATED KILN
This study was carried out to investigate the applicability of sawdust operated kiln developed by Senadheera(2009), by investigating the factors affecting its operation such as burner and cost efficiencies.Most efficientsawdust feeding rate for the burner was found to be 60 g min-1 having particle diameter greater than 1 mm.Kiln was tested by seasoning Rubber (Hevea brasiliensis), Mahogany (Swietenia macrophylla),Lunumidella (Melia dubia) and Albizia (Paraserianthes falcataria). Albizia showed the highest drying rate,followed by Rubber, Lunumidella and Mahogany. This sawdust operated kiln consumed 144 hours to dry 25ft3 of 25 mm thick rubber wood from green conditions to 13% of moisture content. The sawdust operatedkiln in the present study showed the lowest cost efficiency compared with two other industrially operatingkilns in the country. The highest cost efficiency was observed in the kiln at Rowood Lanka Pvt Ltd.However, according to cost â benefit analysis carried out for three kilns, kiln at State Timber Corporationshowed its ability for a long run enterprise. Each kiln contributed approximately 25% of cost on energy outof total seasoning cost. Cost of seasoning per unit volume of timber and cost of seasoning per unit volume oftimber per unit time for this kiln was 1.7 and 2.5 fold higher than that of kiln at Rowood Lanka Pvt Ltdrespectively. It was found that sawdust operated kiln in the present study will not be sustained as anenterprise due to higher cost of seasoning.Key words: kiln seasoning, sawdust, sawdust operated kiln, drying rate, cost efficiency, cost benefitanalysi
Electrical characterization of molecular beam epitaxy grown mercury-cadmium-tellurium alloy under low magnetic field strength.
Electrical characterization of molecular beam epitaxy grown mercury-cadmium-tellurium alloy under low magnetic field strength
Analysis of low doping limitation in molecular beam epitaxially grown HgCdTe(211)B epitaxial layers
Passivation effect on optical and electrical properties of molecular beam epitaxy-grown HgCdTe/CdTe/Si layers
Low-temperature activation of As in Hg1âxCdxTe(211) grown on Si by molecular beam epitaxy
Minority carrier lifetime in indium-doped HgCdTe(211)B epitaxial layers grown by molecular beam epitaxy
Advances in large-area Hg1âxCdxTe photovoltaic detectors for remote-sensing applications
- âŠ