101 research outputs found
Chondroitin sulfates and their binding molecules in the central nervous system
Chondroitin sulfate (CS) is the most abundant glycosaminoglycan (GAG) in the central nervous system (CNS) matrix. Its sulfation and epimerization patterns give rise to different forms of CS, which enables it to interact specifically and with a significant affinity with various signalling molecules in the matrix including growth factors, receptors and guidance molecules. These interactions control numerous biological and pathological processes, during development and in adulthood. In this review, we describe the specific interactions of different families of proteins involved in various physiological and cognitive mechanisms with CSs in CNS matrix. A better understanding of these interactions could promote a development of inhibitors to treat neurodegenerative diseases
Anti-CD11a treatment for psoriasis concurrently increases circulating T-cells and decreases plaque T-cells, consistent with inhibition of cutaneous T-cell trafficking.
Fibroblast growth factor promotes survival of dissociated hippocampal neurons and enhances neurite extension.
Anti-CD11a treatment for psoriasis concurrently increases circulating T-cells and decreases plaque T-cells, consistent with inhibition of cutaneous T-cell trafficking.
Basic Fibroblast Growth Factor in the Mature Brain and Its Possible Role in Alzheimer's Disease
Effects of a Neurotrophic Factor (FGF) on Development, Regeneration and Synaptic Plasticity of Central Neurons
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