22,387 research outputs found
Stress and large-scale spatial structures in dense, driven granular flows
We study the appearance of large-scale dynamical heterogeneities in a
simplified model of a driven, dissipative granular system. Simulations of
steady-state gravity-driven flows of inelastically colliding hard disks show
the formation of large-scale linear structures of particles with a high
collision frequency. These chains can be shown to carry much of the collisional
stress in the system due to a dynamical correlation that develops between the
momentum transfer and time between collisions in these "frequently-colliding"
particles. The lifetime of these dynamical stress heterogeneities is seen to
grow as the flow velocity decreases towards jamming, leading to slowly decaying
stress correlations reminiscent of the slow dynamics observed in supercooled
liquids.Comment: 8 pages, 6 figure
Spin-dependent phenomena and device concepts explored in (Ga,Mn)As
Over the past two decades, the research of (Ga,Mn)As has led to a deeper
understanding of relativistic spin-dependent phenomena in magnetic systems. It
has also led to discoveries of new effects and demonstrations of unprecedented
functionalities of experimental spintronic devices with general applicability
to a wide range of materials. In this article we review the basic material
properties that make (Ga,Mn)As a favorable test-bed system for spintronics
research and discuss contributions of (Ga,Mn)As studies in the general context
of the spin-dependent phenomena and device concepts. Special focus is on the
spin-orbit coupling induced effects and the reviewed topics include the
interaction of spin with electrical current, light, and heat.Comment: 47 pages, 41 figure
Offside goals and induced breaches of contract
An analysis of Global Resources Group Ltd v Mackay which explores the possibility of building links between the offside goals rule and nominate delict of inducing breach of contract
On a model mechanism for the spatial patterning of teeth primordia in the Alligator
We propose a model mechanism for the initiation and spatial positioning of teeth primordia in the alligator,Alligator mississippiensis. Detailed embryological studies by Westergaard & Ferguson (1986, 1987, 1990) show that jaw growth plays a crucial role in the developmental patterning of the tooth initiation process. Based on biological data we develop a reaction-diffusion mechanism, which crucially includes domain growth. The model can reproduce the spatial pattern development of the first seven teeth primordia in the lower half jaw ofA. mississippiensis. The results for the precise spatio-temporal sequence compare well with detailed developmental experiments
The Specific Globular Cluster Frequencies of Dwarf Elliptical Galaxies from the Hubble Space Telescope
The specific globular cluster frequencies (S_N) for 24 dwarf elliptical (dE)
galaxies in the Virgo and Fornax Clusters and the Leo Group imaged with the
Hubble Space Telescope are presented. Combining all available data, we find
that for nucleated dEs --- which are spatially distributed like giant
ellipticals in galaxy clusters --- S_N(dE,N)=6.5 +- 1.2 and S_N increases with
M_V, while for non-nucleated dEs --- which are distributed like late-type
galaxies --- S_N(dE,noN)=3.1 +- 0.5 and there is little or no trend with M_V.
The S_N values for dE galaxies are thus on average significantly higher than
those for late-type galaxies, which have S_N < 1. This suggests that dE
galaxies are more akin to giant Es than to late-type galaxies. If there are
dormant or stripped irregulars hiding among the dE population, they are likely
to be among the non-nucleated dEs. Furthermore, the similarities in the
properties of the globular clusters and in the spatial distributions of dE,Ns
and giant Es suggest that neither galaxy mass or galaxy metallicity is
responsible for high values of S_N. Instead, most metal-poor GCs may have
formed in dwarf-sized fragments that merged into larger galaxies.Comment: 12 pages (uses aaspp4.sty), 2 figures, 1 table, to appear in the
Astrophysical Journa
Anthelmintic tolerance in free-living and facultative parasitic isolates of Halicephalobus (Panagrolaimidae)
Studies on anthelmintic resistance in equine parasites do not include facultative parasites. Halicephalobus gingivalis is a free-living bacteriovorous nematode and a known facultative parasite of horses with a strong indication of some form of tolerance to common anthelmintic drugs. This research presents the results of an in vitro study on the anthelmintic tolerance of several isolates of Halicephalobus to thiabendazole and ivermectin using an adaptation of the Micro-Agar Larval Development Test hereby focusing on egg hatching and larval development. Panagrellus redivivus and Panagrolaimus superbus were included as a positive control. The results generally show that the anthelmintic tolerance of Halicephalobus to both thiabendazole and ivermectin was considerably higher than that of the closely related Panagrolaimidae and, comparing to other studies, than that of obligatory equine parasites. Our results further reveal a remarkable trend of increasing tolerance from fully free-living isolates towards horse-associated isolates. In vitro anthelmintic testing with free-living and facultative parasitic nematodes offers the advantage of observing drug effect on the complete lifecycle as opposed to obligatory parasites which can only be followed until the third larval stage. We therefore propose Halicephalobus gingivalis as an experimental tool to deepen our understanding of the biology of anthelmintic tolerance
Acute post-disaster medical needs of patients with diabetes: emergency department use in New York City by diabetic adults after Hurricane Sandy.
OBJECTIVE: To evaluate the acute impact of disasters on diabetic patients, we performed a geospatial analysis of emergency department (ED) use by New York City diabetic adults in the week after Hurricane Sandy.
RESEARCH DESIGN AND METHODS: Using an all-payer claims database, we retrospectively analyzed the demographics, insurance status, and medical comorbidities of post-disaster ED patients with diabetes who lived in the most geographically vulnerable areas. We compared the patterns of ED use among diabetic adults in the first week after Hurricane Sandy\u27s landfall to utilization before the disaster in 2012.
RESULTS: In the highest level evacuation zone in New York City, postdisaster increases in ED visits for a primary or secondary diagnosis of diabetes were attributable to a significantly higher proportion of Medicare patients. Emergency visits for a primary diagnosis of diabetes had an increased frequency of certain comorbidities, including hypertension, recent procedure, and chronic skin ulcers. Patients with a history of diabetes visited EDs in increased numbers after Hurricane Sandy for a primary diagnosis of myocardial infarction, prescription refills, drug dependence, dialysis, among other conditions.
CONCLUSIONS: We found that diabetic adults aged 65 years and older are especially at risk for requiring postdisaster emergency care compared to other vulnerable populations. Our findings also suggest that there is a need to support diabetic adults particularly in the week after a disaster by ensuring access to medications, aftercare for patients who had a recent procedure, and optimize their cardiovascular health to reduce the risk of heart attacks
Measurements of the Diffuse Ultraviolet Background and the Terrestrial Airglow with the Space Telescope Imaging Spectrograph
Far-UV observations in and near the Hubble Deep Fields demonstrate that the
Space Telescope Imaging Spectrograph (STIS) can potentially obtain unique and
precise measurements of the diffuse far-ultraviolet background. Although STIS
is not the ideal instrument for such measurements, high-resolution images allow
Galactic and extragalactic objects to be masked to very faint magnitudes, thus
ensuring a measurement of the truly diffuse UV signal. The programs we have
analyzed were not designed for this scientific purpose, but would be sufficient
to obtain a very sensitive measurement if it were not for a weak but
larger-than-expected signal from airglow in the STIS 1450-1900 A bandpass. Our
analysis shows that STIS far-UV crystal quartz observations taken near the limb
during orbital day can detect a faint airglow signal, most likely from NI\1493,
that is comparable to the dark rate and inseparable from the far-UV background.
Discarding all but the night data from these datasets gives a diffuse
far-ultraviolet background measurement of 501 +/- 103 ph/cm2/sec/ster/A, along
a line of sight with very low Galactic neutral hydrogen column (N_HI = 1.5E20
cm-2) and extinction (E(B-V)=0.01 mag). This result is in good agreement with
earlier measurements of the far-UV background, and should not include any
significant contribution from airglow. We present our findings as a warning to
other groups who may use the STIS far-UV camera to observe faint extended
targets, and to demonstrate how this measurement may be properly obtained with
STIS.Comment: 7 pages, Latex. 4 figures. Uses corrected version of emulateapj.sty
and apjfonts.sty (included). Accepted for publication in A
Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity
Virus infection of mammalian cells is sensed by pattern recognition receptors and leads to an innate immune response that restricts virus replication and induces adaptive immunity. In response, viruses have evolved many countermeasures that enable them to replicate and be transmitted to new hosts, despite the host innate immune response. Poxviruses, such as vaccinia virus (VACV), have large DNA genomes and encode many proteins that are dedicated to host immune evasion. Some of these proteins are secreted from the infected cell, where they bind and neutralize complement factors, interferons, cytokines and chemokines. Other VACV proteins function inside cells to inhibit apoptosis or signalling pathways that lead to the production of interferons and pro-inflammatory cytokines and chemokines. In this review, these VACV immunomodulatory proteins are described and the potential to create more immunogenic VACV strains by manipulation of the gene encoding these proteins is discussed
An insight into some innovative cycles for aircraft propulsion
Emissions are important drivers in the design and use of aero-engines. This paper presents a part of the work carried out in the VITAL (EnVIronmenTALly aero-engine) project; it consists of a parameter study on the application of three innovative thermodynamic cycles to aircraft propulsion, looking for benefits on fuel consumption, carbon dioxide, nitrogen oxides, and noise. These cycles are intercooler-regenerative, the wave rotor topping, and the constant volume combustor cycles. The work, starting from a next-generation ultra-high bypass ratio turbofan, the baseline, and considering two possible design conditions, presents the influence of the application of these new cycles or design changes to the baseline on emissions and on the required technological level, represented by the turbine entry temperature (TET). VITAL is a project supported by the Sixth Framework Programme of the European Communities. The results showthat some significant benefits on emissions can be achieved although they are linked to significant technology improvements and in-depth studies of the new components involved in cycle implementation
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