1937 Les Bois

https://scholarworks.boisestate.edu/student_yearbooks/1002/thumbnail.jp

1939 Les Bois

https://scholarworks.boisestate.edu/student_yearbooks/1004/thumbnail.jp

Kinetic modulation of bacterial hydrolases by microbial community structure in coastal waters

In this study, we hypothesized that shifts in the kinetic parameters of extracellular hydrolytic enzymes may occur as a consequence of seasonal environmental disturbances and would reflect the level of adaptation of the bacterial community to the organic matter of the ecosystem. We measured the activities of enzymes that play a key role in the bacterial growth (leucine aminopeptidase, β- and α-glucosidases) in surface coastal waters of the Eastern Cantabrian Sea and determined their kinetic parameters by computing kinetic models of distinct complexity. Our results revealed the existence of two clearly distinct enzymatic systems operating at different substrate concentrations: a high-affinity system prevailing at low substrate concentrations and a low-affinity system characteristic of high substrate concentrations. These findings could be the result of distinct functional bacterial assemblages growing concurrently under sharp gradients of high-molecular-weight compounds. We constructed an ecological network based on contemporaneous and time-delayed correlations to explore the associations between the kinetic parameters and the environmental variables. The analysis revealed that the recurring phytoplankton blooms registered throughout the seasonal cycle trigger the wax and wane of those members of the bacterial community able to synthesize and secrete specific enzymes.his work has been supported by projects EFICIENCIA (CTM2006-08023) and CAMBIO (CTM2010-19308), co-financed by Ministry of Science and Innovation of the Spanish Government and European FEDER founds, the Basque Government (Grant to Research Group IT1657-22) and by the UPV/EHU (Grant to Research Group GIU10/17). Naiara Abad was supported by a scholarship from the Basque Government and currently by the grant Margarita Salas from the European Union—NextGenerationEU through the UPV/EHU. Zuriñe Baña and Ainhoa Uranga were financed by scholarships from the UPV/EHU

1940 Les Bois

https://scholarworks.boisestate.edu/student_yearbooks/1005/thumbnail.jp

Automated Neuromelanin Imaging as a Diagnostic Biomarker for Parkinson's Disease

Published onlineWe aimed to analyze the diagnostic accuracy of an automated segmentation and quantification method of the SNc and locus coeruleus (LC) volumes based on neuromelanin (NM)-sensitive MRI (NM-MRI) in patients with idiopathic (iPD) and monogenic (iPD) Parkinson's disease (PD). Thirty-six patients (23 idiopathic and 13 monogenic PARKIN or LRRK2 mutations) and 37 age-matched healthy controls underwent 3T-NM-MRI. SNc and LC volumetry were performed using fully automated multi-image atlas segmentation. The diagnostic performance to differentiate PD from controls was measured using the area under the curve (AUC) and likelihood ratios based on receiver operating characteristic (ROC) analyses. We found a significant reduction of SNc and LC volumes in patients, when compared to controls. ROC analysis showed better diagnostic accuracy when using SNc volume than LC volume. Significant differences between ipsilateral and contralateral SNc volumes, in relation to the more clinically affected side, were found in patients with iPD (P=0.007). Contralateral atrophy in the SNc showed the highest power to discriminate PD subjects from controls (AUC, 0.93-0.94; sensitivity, 91%-92%; specificity, 89%; positive likelihood ratio: 8.4-8.5; negative likelihood ratio: 0.09-0.1 at a single cut-off point). Interval likelihood ratios for contralateral SNc volume improved the diagnostic accuracy of volumetric measurements. SNc and LC volumetry based on NM-MRI resulting from the automated segmentation and quantification technique can yield high diagnostic accuracy for differentiating PD from health and might be an unbiased disease biomarker.Supported by the Fund for Health Research Foundation (FIS-ISCIII), Spanish Ministry of Economy and Competitiveness (reference: PI 13/02211); Spanish Ministry of Science and Innovation SAF2006-10126 (2006-2009), SAF2010-22329-C02-01 (2011-2013), and SAF2013-47939-R (to P.P.); project 061131 from the “Fundació La Marató de TV3” and by the UTE project FIMA, Spain (to P.P.). C.O.d.S. and A.M.B. were supported by Spanish Ministry of Economy and Competitiveness DPI2012-38090-C03-02 and TEC2013-48552-C2-1-R, respectively.Publicad

Spartan Daily, February 25, 1991

Volume 96, Issue 19https://scholarworks.sjsu.edu/spartandaily/8087/thumbnail.jp

Spartan Daily, February 25, 1991

Volume 96, Issue 19https://scholarworks.sjsu.edu/spartandaily/8087/thumbnail.jp

Spartan Daily, March 8, 1991

Volume 96, Issue 28https://scholarworks.sjsu.edu/spartandaily/8096/thumbnail.jp

Spartan Daily, November 29, 1990

Volume 95, Issue 60https://scholarworks.sjsu.edu/spartandaily/8059/thumbnail.jp