Clinical use of rivaroxaban: pharmacokinetic and pharmacodynamic rationale for dosing regimens in different indications.

Target-specific oral anticoagulants have become increasingly available as alternatives to traditional agents for the management of a number of thromboembolic disorders. To date, the direct Factor Xa inhibitor rivaroxaban is the most widely approved of the new agents. The dosing of rivaroxaban varies and adheres to specific schedules in each of the clinical settings in which it has been investigated. These regimens were devised based on the results of phase II dose-finding studies and/or pharmacokinetic modeling, and were demonstrated to be successful in randomized, phase III studies. In most cases, the pharmacodynamic profile of rivaroxaban permits once-daily dosing. A once-daily dose is indicated for the prevention of venous thromboembolism (VTE) in patients undergoing hip or knee replacement surgery, the long-term prevention of stroke in patients with non-valvular atrial fibrillation, and the long-term secondary prevention of recurrent VTE. Twice-daily dosing is required in the acute phase of treatment in patients with VTE and in the combination of rivaroxaban with standard single or dual antiplatelet therapy for secondary prevention after acute coronary syndrome events. This article reviews the empirical and clinical rationale supporting the dose regimens of rivaroxaban in each clinical setting

Digital Communication and Its Influence on Consumer Habits During Health Emergencies

Virtual Social Networks, such as Facebook, text messages, and instant messaging, have produced a great flow of real-time data like never seen before. This has turned multitasking into an information management strategy (Campos, 2018, p. 5). Currently, social networks have become a massive economic medium and generated many expectations due to the growth potential they offer. The sample of this study was made up of 213 marketing students of the Polytechnic School of Chimborazo – 110 female and 103 male students from the Coast, Sierra, and Amazon regions. Results show that digital communication informs and influences the decision of a consumer to purchase goods and services. Keywords: digital marketing, consumers, services, social networks. Resumen Las Redes Sociales Virtuales, tales como Facebook, mensajes de texto y mensajería instantánea han producido un gran flujo de datos en tiempo real, como nunca antes se vio. Lo que ha convertido a la multitarea en una estrategia de gestión de la información. (Campos, 2018, pág. 5), en la actualidad las redes sociales se han convertido en un medio económico, oportuno y masivo, y han generado muchas expectativas por el potencial que brindan al desarrollo de las diferentes funciones en una organización. La muestra objeto de estudio la constituyeron 213 estudiantes de la Carrera de Mercadotecnia de la Escuela Superior Politécnica de Chimborazo, 110 educandos del género femenino y 103 del género masculino y pertenecen a las regiones Costa, Sierra y Amazonía. Los resultados obtenidos muestran que la comunicación digital informa e influye en la decisión de compra de bienes y servicios sin que los mismos se encuentren estrechamente relacionados con la satisfacción de sus necesidades elementales. Palabras Clave: marketing digital, consumidores, servicios, redes sociales

Recent Advances in Chromospheric and Coronal Polarization Diagnostics

I review some recent advances in methods to diagnose polarized radiation with which we may hope to explore the magnetism of the solar chromosphere and corona. These methods are based on the remarkable signatures that the radiatively induced quantum coherences produce in the emergent spectral line polarization and on the joint action of the Hanle and Zeeman effects. Some applications to spicules, prominences, active region filaments, emerging flux regions and the quiet chromosphere are discussed.Comment: Review paper to appear in "Magnetic Coupling between the Interior and the Atmosphere of the Sun", eds. S. S. Hasan and R. J. Rutten, Astrophysics and Space Science Proceedings, Springer-Verlag, 200

Conversational eyebrow frowns facilitate question identification:An online study using virtual avatars

Conversation is a time-pressured environment. Recognizing a social action (the ‘‘speech act,’’ such as a question requesting information) early is crucial in conversation to quickly understand the intended message and plan a timely response. Fast turns between interlocutors are especially relevant for responses to questions since a long gap may be meaningful by itself. Human language is multimodal, involving speech as well as visual signals from the body, including the face. But little is known about how conversational facial signals contribute to the communication of social actions. Some of the most prominent facial signals in conversation are eyebrow movements. Previous studies found links between eyebrow movements and questions, suggesting that these facial signals could contribute to the rapid recognition of questions. Therefore, we aimed to investigate whether early eyebrow movements (eyebrow frown or raise vs. no eyebrow movement) facilitate question identification. Participants were instructed to view videos of avatars where the presence of eyebrow movements accompanying questions was manipulated. Their task was to indicate whether the utterance was a question or a statement as accurately and quickly as possible. Data were collected using the online testing platform Gorilla. Results showed higher accuracies and faster response times for questions with eyebrow frowns, suggesting a facilitative role of eyebrow frowns for question identification. This means that facial signals can critically contribute to the communication of social actions in conversation by signaling social action-specific visual information and providing visual cues to speakers’ intentions