Farming system design for innovative crop-livestock integration in Europe

The development of integrated crop-livestock systems (ICLS) is a major challenge for the ecological modernisation of agriculture but appears difficult to implement at a large scale. A participatory method for ICLS design has been developed and implemented in 15 case studies across Europe, representing a range of production systems, challenges, constraints and resources for innovation. Local stakeholders, primarily farmers, but also cooperatives, environmental-association representatives and natural-resource managers, were involved in the identification of challenges and existing initiatives of crop-livestock integration; in the design of new options at field, farm and territory levels; and then in qualitative multicriteria assessment of these options. A conceptual framework based on a conceptual model (crops, grasslands, animals) was developed to act as a boundary object in the design step and invite innovative thinking in 'metabolic' and 'ecosystemic' approaches. A diversity of crops and grasslands interacting with animals appeared central for designing sustainable farming systems at the territory level, providing and benefitting from ecosystem services. Within this diversity, we define three types of integrated systems according to their degrees of spatial and temporal coordination: complementarity, local synergy, territorial synergy. Moreover, the options for cooperation and collective organisation between farmers and other stakeholders in territories to organise and manage this diversity of land use revealed opportunities for smart social innovation. The qualitative multicriteria assessment identified farmer workload as the main issue of concern while demonstrating expected benefits of ICLS simultaneously for economic, agronomic, environmental and social criteria. This study concludes that participatory design of ICLS based on a generic multi-level and multi-domain framework and a methodology to deal with a local context can identify new systems to be tested. Further assessment and redesign work will be performed in later stages of the European FP7 CANTOGETHER project.authorsversionPeer reviewe

Variation of LDMC and SLA Relationship Between Growth Forms in Natural Grasslands

In agro-ecological studies, there is a growing interest in measuring both leaf dry matter content (LDMC) and specific leaf area (SLA). This interest lies on the fact that leaf traits are linked to gradients of environmental factors and ecosystem functions. Working with three contrasting wild species, Garnier et al. (2001) proposed a model linking these two traits. The model shows a relatively simple non linear and negative correlation between LDMC and SLA. Nevertheless, none of the species used to build the model were grasses (GRA) or forb rosettes (ROS = i.e. dicotyledonous with large entire leaves and absence of stem at the vegetative stage); the species which make the largest contribution to the standing biomass of most natural grasslands. Furthermore, due to the divergent range of LDMC (and not SLA) values between these growth forms, Cruz et al. (2002) proposed that grass records alone could be used as an indicator of fertility gradients. The aim of this paper was to analyse discrepancies in the LDMC - SLA correlation with respect to model predictions in order to consider them in any development of LDMC-based tools for the management of natural vegetation

Integrating agri-environmental indicators, ecosystem services assessment, life cycle assessment and yield gap analysis to assess the environmental sustainability of agriculture

Agriculture's primary function is the production of food, feed, fibre and fuel for the fast-growing world population. However, it also affects human health and ecosystem integrity. Policymakers make policies in order to avoid harmful impacts. How to assess such policies is a challenge. In this paper, we propose a conceptual framework to help evaluate the impacts of agricultural policies on the environment. Our framework represents the global system as four subsystems and their interactions. These four components are the cells of a 2 by 2 matrix [Agriculture, Rest of the word]; [Socio-eco system, Ecological system]. We then developed a set of indicators for environmental issues and positioned these issues in the framework. To assess these issues, we used four well-known existing approaches: Life Cycle Assessment, Ecosystem Services Analysis, Yield Gap Analysis and Agro-Environmental Indicators. Using these four approaches together provided a more holistic view of the impacts of a given policy on the system. We then applied our framework on existing cover crop policies using an extensive literature survey and analysing the different environmental issues mobilised by the four assessment approaches. This demonstration case shows that our framework may be of help for a full systemic assessment. Despite their differences (aims, scales, standardization, data requirements, etc.), it is possible and profitable to use the four approaches together. This is a significant step forward, though more work is needed to produce a genuinely operational tool. © 2022 The Author

Point Mutations in GLI3 Lead to Misregulation of its Subcellular Localization

Background Mutations in the transcription factor GLI3, a downstream target of Sonic Hedgehog (SHH) signaling, are responsible for the development of malformation syndromes such as Greig-cephalopolysyndactyly-syndrome (GCPS), or Pallister-Hall-syndrome (PHS). Mutations that lead to loss of function of the protein and to haploinsufficiency cause GCPS, while truncating mutations that result in constitutive repressor function of GLI3 lead to PHS. As an exception, some point mutations in the C-terminal part of GLI3 observed in GCPS patients have so far not been linked to loss of function. We have shown recently that protein phosphatase 2A (PP2A) regulates the nuclear localization and transcriptional activity a of GLI3 function. Principal Findings We have shown recently that protein phosphatase 2A (PP2A) and the ubiquitin ligase MID1 regulate the nuclear localization and transcriptional activity of GLI3. Here we show mapping of the functional interaction between the MID1-α4-PP2A complex and GLI3 to a region between amino acid 568-1100 of GLI3. Furthermore we demonstrate that GCPS-associated point mutations, that are located in that region, lead to misregulation of the nuclear GLI3-localization and transcriptional activity. GLI3 phosphorylation itself however appears independent of its localization and remains untouched by either of the point mutations and by PP2A-activity, which suggests involvement of an as yet unknown GLI3 interaction partner, the phosphorylation status of which is regulated by PP2A activity, in the control of GLI3 subcellular localization and activity. Conclusions The present findings provide an explanation for the pathogenesis of GCPS in patients carrying C-terminal point mutations, and close the gap in our understanding of how GLI3-genotypes give rise to particular phenotypes. Furthermore, they provide a molecular explanation for the phenotypic overlap between Opitz syndrome patients with dysregulated PP2A-activity and syndromes caused by GLI3-mutations

Monographie Selenium

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