5,678 research outputs found
The Impact on Maryland\u27s Budget of Allowing Same-Sex Couples to Marry
This analysis estimates the potential impact of extending marriage rights to same-sex couples on Maryland’s state budget. Drawing on data from the U.S. Census Bureau and Maryland statistical reports, we estimate that extending marriage rights to same-sex couples would result in a net gain of approximately $3.2 million each year. This net gain is attributable to savings in expenditures on meanstested public benefit programs and an increase in sales and lodging tax revenue from weddings and wedding-related tourism
Conduction Block in the Peripheral Nervous System in Experimental Allergic Encephalomyelitis
Experimental Allergic Encephalomyelitis (EAE) has been widely studied as a model of multiple sclerosis, a central nervous system (CNS) disease of unknown aetiology. The clinical features of both EAE and multiple sclerosis provide the only guide to the progress and severity of these diseases, and are used to assess the response to treatment. In such comparisons the clinical features of EAE are assumed to be due to lesions in the CNS, but in this disease there is also histological evidence of damage to the peripheral nervous system (1-8). However, the functional consequences of such peripheral lesions have been entirely ignored. To examine this, we have studied nerve conduction in rabbits with EAE. We report here that most of the large diameter afferent fibres are blocked in the region of the dorsal root ganglion and at the dorsal root entry zone, thus accounting for the loss of tendon jerks and also, through the severe loss of proprioceptive information, the ataxia of thse animals. We conclude that whenever clinical comparisons are made between EAE and multiple sclerosis, the pathophysiology associated with histological damage of the peripheral nervous system must be taken into account
The Pathophysiology of Acute Experimental Allergic Encephalomyelitis in the Rabbit
Clinical, histological and electrophysiological studies were performed on rabbits with acute experimental allergic encephalomyelitis (EAE). The clinical features were similar to those previously described, with the notable exception of the new findings of areflexia, respiratory slowing and hypothermia. The histological findings were also similar to those previously reported, with inflammatory demyelinating lesions both in the central and peripheral nervous system, especially the dorsal root ganglia. Electrophysiological studies performed one to nine days after the onset of neurological signs demonstrated conduction block in a high proportion of the large diameter afferents in the lumbosacral and thoracic dorsal root ganglia. Single fibre studies with spike-triggered averaging confirmed the conduction block in the dorsal root ganglia. That the conduction block was due to demyelination was indicated by slowing of conduction in large diameter fibres, normal conduction in unmyelinated fibres and the specific effects of temperature and of the potassium channel blocking agent, 4-aminopyridine. These conduction abnormalities in the peripheral nervous system, focused on the dorsal root ganglia, account for the postural disturbance, hypotonia, ataxia and areflexia in rabbits with EAE. Such conduction block is likely to mask the expression of any lesions of the central nervous system that alone could produce similar signs. The implications of these findings for the human demyelinating diseases are discussed
Incoherent dynamics in neutron-matter interaction
Coherent and incoherent neutron-matter interaction is studied inside a
recently introduced approach to subdynamics of a macrosystem. The equation
describing the interaction is of the Lindblad type and using the Fermi
pseudopotential we show that the commutator term is an optical potential
leading to well-known relations in neutron optics. The other terms, usually
ignored in optical descriptions and linked to the dynamic structure function of
the medium, give an incoherent contribution to the dynamics, which keeps
diffuse scattering and attenuation of the coherent beam into account, thus
warranting fulfilment of the optical theorem. The relevance of this analysis to
experiments in neutron interferometry is briefly discussed.Comment: 15 pages, revtex, no figures, to appear in Phys. Rev.
Mirrors for slow neutrons from holographic nanoparticle-polymer free-standing film-gratings
We report on successful tests of holographically arranged grating-structures
in nanoparticle-polymer composites in the form of 100 microns thin
free-standing films, i.e. without sample containers or covers that could cause
unwanted absorption/incoherent scattering of very-cold neutrons. Despite their
large diameter of 2 cm, the flexible materials are of high optical quality and
yield mirror-like reflectivity of about 90% for neutrons of 4.1 nm wavelength
- …