Heterogeneous dacitic magmas and the role of crustal assimilation in the Sierra Chichinautzin Volcanic Field, central Mexico: a perspective from crustal xenoliths

The Sierra Chichinautzin Volcanic Field (SCVF) is constituted by diverse monogenetic volcanic structures with heterogeneous chemical composition. Dacitic magmas are widely distributed in this volcanic field and are the most felsic products. Tabaquillo lava is an example of such felsic rocks, it is porphyritic and highly crystalline, constituted by large phenocrysts of plagioclase and quartz (>1 mm long) + ortho and clinopyroxene + biotite and minor amphibole. Coarse-grained and equigranular clasts classified as ‘crystal-rich enclaves’ are also common in the lava flow, with variable compositions (basaltic andesite, andesite, and dacite) and ages of 0.35–0.36 Ma. The presence of metasandstone crustal xenoliths in the Tabaquillo lava flow, with a maximum sedimentation age of 150 Ma, attests to crustal assimilation of the Guerrero terrain rocks. Isotopic data of Tabaquillo lava and other volcanic rocks from the SCVF show notable variations (87Sr/86Sr = 0.70379–0.70474; 143Nd/144Nd = 0.51272–0.51288). Most of them lie in the mantle array but trending to the more radiogenic metasandstone xenolith and Guerrero terrain rocks (87Sr/86Sr = 0.71271 and 0.71627), suggesting that SCVF magmas have partially assimilated these rocks. Interaction between SCVF magmas with metasandstone, quartzite, and skarn rocks took place at depths > 1.3 km, imprinting geochemical and isotopic characteristics on the felsic magmas and produced the diverse compositional lithologies in the entire SCVF. Additionally, crystal-rich enclaves produced during previous magmatic pulses stalled at different depths, were later mixed with the ascending mafic magma, and subsequently incorporated into the crystal cargo that reached the surface. The common presence of quartz crystals (sometimes with reaction rims of clinopyroxene) found in many SCVF lavas could derive from the crystal-rich magmatic enclaves and/or from the metasandstone basement rocks.</p

Polysaccharide Films Built by Simultaneous or Alternate Spray: A Rapid Way to Engineer Biomaterial Surfaces

We investigated polysaccharide films obtained by simultaneous and alternate spraying of a chitosan (CHI) solution as polycation and hyaluronic acid (HA), alginate (ALG), and chondroitin sulfate (CS) solutions as polyanions. For simultaneous spraying, the film thickness increases linearly with the cumulative spraying time and passes through a maximum for polyanion/CHI molar charge ratios lying between 0.6 and 1.2. The size of polyanion/CHI complexes formed in solution was compared with the simultaneously sprayed film growth rate as a function of the polyanion/CHI molar charge ratio. A good correlation was found. This suggests the importance of polyanion/polycation complexation in the simultaneous spraying process. Depending on the system, the film topography is either liquid-like or granular. Film biocompatibility was evaluated using human gingival fibroblasts. A small or no difference is observed in cell viability and adhesion between the two deposition processes. The CHI/HA system appears to be the best for cell adhesion inducing the clustering of CD44, a cell surface HA receptor, at the membrane of cells. Simultaneous or alternate spraying of CHI/HA appears thus to be a convenient and fast procedure for biomaterial surface modifications

Bioinspired Nanofeatured Substrates: Suitable Environment for Bone Regeneration

International audienceBone mimicking coatings provide a complex microenvironment in which material, through its inherent properties (such as nanostructure and composition), affects the commitment of stem cells into bone lineage and the production of bone tissue regulating factors required for bone healing and regeneration. Herein, a bioactive mineral/biopolymer composite made of calcium phosphate/chitosan and hyaluronic acid (CaP-CHI-HA) was elaborated using a versatile simultaneous spray coating of interacting species. The resulting CaP-CHI-HA coating was mainly constituted of bioactive, carbonated and crystalline hydroxyapatite with 277 ± 98 nm of roughness, 1 μm of thickness, and 2.3 ± 1 GPa of stiffness. After five days of culture, CaP-CHI-HA suggested a synergistic effect of intrinsic biophysical features and biopolymers on stem cell mechanobiology and nuclear organization, leading to the expression of an early osteoblast-like phenotype and the production of bone tissue regulating factors such as osteoprotegerin and vascular endothelial growth factor. More interestingly, amalgamation with biopolymers conferred to the mineral a bacterial antiadhesive property. These significant data shed light on the potential regenerative application of CaP-CHI-HA bioinspired coating in providing a suitable environment for stem cell bone regeneration and an ideal strategy to prevent implant-associated infections