The glucocorticoid receptor in inflammatory processes : transrepression is not enough

Glucocorticoids (GCs) are the most commonly used anti-inflammatory agents to treat inflammatory and immune diseases. However, steroid therapies are accompanied by severe side-effects during long-term treatment. The dogma that transrepression of genes, by tethering of the glucocorticoid receptor (GR) to DNA-bound pro-inflammatory transcription factors, is the main anti-inflammatory mechanism, is now challenged. Recent discoveries using conditional GR mutant mice and genomic approaches reveal that transactivation of anti-inflammatory acting genes is essential to suppress many inflammatory disease models. This novel view radically changes the concept to design selective acting GR ligands with a reduced side-effect profile

Slater-Pauling Rule and Curie-Temperature of Co2_2-based Heusler compounds

A concept is presented serving to guide in the search for new materials with high spin polarization. It is shown that the magnetic moment of half-metallic ferromagnets can be calculated from the generalized Slater-Pauling rule. Further, it was found empirically that the Curie temperature of Co$_2$ based Heusler compounds can be estimated from a seemingly linear dependence on the magnetic moment. As a successful application of these simple rules, it was found that Co$_2$FeSi is, actually, the half-metallic ferromagnet exhibiting the highest magnetic moment and the highest Curie temperature measured for a Heusler compound

A Dialogue : On European Borders, Black Movement, and the History of Social Death.

This article presents a dialogue between Sabine Broeck and P. Khalil Saucier about Black social death and white empathy in contemporary Europe. It is written as a starting point to speak about black movement, European borders, and social death in the midst of almost weekly ship-wrecks in the Mediterrenean Sea; events that Broeck and Saucier read as the constitutive element of the longe duree of black genocide in Europe; the consolidation of late European modernity

Non-equilibrium condensation and coarsening of field-driven dipolar colloids

In colloidal suspensions, self-organization processes can be easily fueled by external fields. One particularly interesting class of phenomena occurs in monolayers of dipolar particles that are driven by rotating external fields. Here we report results from a computer simulation study of such systems focusing on the clustering behavior also observed in recent experiments. The key result of this paper is a novel interpretation of this pattern formation phenomenon: We show the clustering to be a by-product of a vapor-liquid first order phase transition. In fact, the observed dynamic coarsening process corresponds to the spindodal demixing that occurs during such a transitionComment: 6 pages, 5 figure

State and Local Taxes

The year 1968 may have been more significant for constitutional changes that did not occur than for those that did. Proposition 9, the so-called Watson Amendment, would have imposed severe limitations on the property tax as a source of revenue. According to its opponents, this measure, which was defeated, would have resulted in a drastic restriction on the borrowing power of the state and its political subdivisions, and would have required an extensive shift to other taxes if the present level of expenditure were to be maintained. But Proposition I-A, affording a moderate amount of property tax relief was adopted by the voters and became Article 13 section 1d of the Constitution. It was implemented by Senate Bill 8. The specific provisions of this bill will be discussed under the Property Tax and Personal Income Tax headings.Legislative changes in other fields will be discussed under the headings relating to the particular taxes affected

From book to stage to screen: semiotic transformations of Gothic horror genre conventions

This paper adopts a multimodal social semiotic approach for exploring the semiotic changes involved in the transformation of a novel into stage and screen productions. It examines how semiotic resources are deployed in each medium through elements of mise-en-scène, such as speech, music, sound, lighting, props, staging, and cinematographic techniques, and the viewing perspectives that are thus established for audiences. The genre of Gothic horror is selected for this purpose, given how this form of performance has transfixed audiences for centuries and has been adapted for both the stage and the screen. In order to demonstrate how each performance medium has produced its own unique set of foregrounding devices to enthral and captivate audiences, a comparative analysis of excerpts from the novel The Woman in Black by Susan Hill, a videotaped theatrical performance, and the 1989 British television film of the same name is undertaken. The paper discusses the implications of the multimodal semiotic approach for developing a better understanding of the semiotic transformations that horror genre conventions undergo in different media and the viewership positions that are thus re-drawn for audiences. The paper concludes with a view of multimodal recontextualisation processes which form the underlying basis of human sociocultural life