Time Management in the Cost Evaluation of Limited Resource Programs

cost techniques, critical path, CPM, Gantt chart, PERT, time management,

Stratigraphy of Palaeocene phosphate pelagic stromatolites (Prebetic Zone, SE Spain)

The hemipelagic domain of the ancient southern continental margin of Iberia is home to a strongly condensed pelagic succession (6–15 cm thick) characterized by the presence of phosphate stromatolites. This succession, probably generated in the slope of the continental margin, records a period of some 9 Ma, corresponding to the latest Maastrichtian to Late Thanetian interval. A microstratigraphical analysis allows for characterizing and biostratigraphically dating six successive developmental stages in the succession, which outline the main environmental evolution of the depositional setting. The Wrst of them determined the generation of a submarine hardground during the latest Maastrichtian to earliest Danian interval. The other Wve are represented by Wve successive microstratigraphical, unconformity-bounded, genetic units, respectively Early– Middle Danian, Late Danian–Early Selandian, intra-Selandian, Late Selandian–Early Thanetian, and Middle–?Late Thanetian in age. The three oldest units are characterized by the accretion of phosphate stromatolites, favoured by very low rates of pelagic sedimentation and by a microbially mediated extra input of phosphate. The two youngest units are dominated by carbonate deposition, which has always taken place at very low rates. Condensed sedimentation was abruptly interrupted at the end of the Palaeocene (?latest Thanetian), when the condensed succession and its hosting substrate were gravitationally slumped and redeposited at the base of the slope in the form of a megadebris Xow that can be now observed in Sierra de Aixorta (Alicante, SE Spain). The Aixorta pelagic phosphatic stromatolites are among the youngest ever described, and their existence suggests that the oceanographic conditions necessary for their development prevailed during most of the Palaeocene, but disappeared during the Late Selandian, never to return

Random PERT: application to physical activity/sports programs

Random PERT, Physical Activity, Sport Programs,

Characteristics and Outcomes of Adult Patients in the PETHEMA Registry with Relapsed or Refractory FLT3-ITD Mutation-Positive Acute Myeloid Leukemia

This retrospective study investigated outcomes of 404 patients with relapsed/refractory (R/R) FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) acute myeloid leukemia (AML) enrolled in the PETHEMA registry, pre-approval of tyrosine kinase inhibitors. Most patients (63%) had received first-line intensive therapy with 3 + 7. Subsequently, patients received salvage with intensive therapy (n = 261), non-intensive therapy (n = 63) or supportive care only (n = 80). Active salvage therapy (i.e., intensive or non-intensive therapy) resulted in a complete remission (CR) or CR without hematological recovery (CRi) rate of 42%. More patients achieved a CR/CRi with intensive (48%) compared with non-intensive (19%) salvage therapy (p < 0.001). In the overall population, median overall survival (OS) was 5.5 months; 1-and 5-year OS rates were 25% and 7%. OS was significantly (p <0.001) prolonged with intensive or non-intensive salvage therapy compared with supportive therapy, and in those achieving CR/CRi versus no responders. Of 280 evaluable patients, 61 (22%) had an allogeneic stem-cell transplant after they had achieved CR/CRi. In conclusion, in this large cohort study, salvage treatment approaches for patients with FLT3-ITD mutated R/R AML were heterogeneous. Median OS was poor with both non-intensive and intensive salvage therapy, with best long-term outcomes obtained in patients who achieved CR/CRi and subsequently underwent allogeneic stem-cell transplant