18 research outputs found
Time Management in the Cost Evaluation of Limited Resource Programs
cost techniques, critical path, CPM, Gantt chart, PERT, time management,
Stratigraphy of Palaeocene phosphate pelagic stromatolites (Prebetic Zone, SE Spain)
The hemipelagic domain of the ancient southern
continental margin of Iberia is home to a strongly condensed
pelagic succession (6–15 cm thick) characterized by
the presence of phosphate stromatolites. This succession,
probably generated in the slope of the continental margin,
records a period of some 9 Ma, corresponding to the latest
Maastrichtian to Late Thanetian interval. A microstratigraphical
analysis allows for characterizing and biostratigraphically
dating six successive developmental stages in
the succession, which outline the main environmental evolution
of the depositional setting. The Wrst of them determined
the generation of a submarine hardground during the
latest Maastrichtian to earliest Danian interval. The other
Wve are represented by Wve successive microstratigraphical,
unconformity-bounded, genetic units, respectively Early–
Middle Danian, Late Danian–Early Selandian, intra-Selandian,
Late Selandian–Early Thanetian, and Middle–?Late
Thanetian in age. The three oldest units are characterized
by the accretion of phosphate stromatolites, favoured by
very low rates of pelagic sedimentation and by a microbially
mediated extra input of phosphate. The two youngest
units are dominated by carbonate deposition, which has
always taken place at very low rates. Condensed sedimentation
was abruptly interrupted at the end of the Palaeocene
(?latest Thanetian), when the condensed succession and its
hosting substrate were gravitationally slumped and redeposited
at the base of the slope in the form of a megadebris
Xow that can be now observed in Sierra de Aixorta
(Alicante, SE Spain). The Aixorta pelagic phosphatic stromatolites
are among the youngest ever described, and their
existence suggests that the oceanographic conditions necessary
for their development prevailed during most of the
Palaeocene, but disappeared during the Late Selandian,
never to return
Random PERT: application to physical activity/sports programs
Random PERT, Physical Activity, Sport Programs,
Qualitative/quantitative integration in the inductive observational study of interactive behaviour: impact of recording and coding among predominating perspectives
The influence of rules manipulation on offensive patterns during small-sided and conditioned games in football
Characteristics and Outcomes of Adult Patients in the PETHEMA Registry with Relapsed or Refractory FLT3-ITD Mutation-Positive Acute Myeloid Leukemia
This retrospective study investigated outcomes of 404 patients with relapsed/refractory (R/R) FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) acute myeloid leukemia (AML) enrolled in the PETHEMA registry, pre-approval of tyrosine kinase inhibitors. Most patients (63%) had received first-line intensive therapy with 3 + 7. Subsequently, patients received salvage with intensive therapy (n = 261), non-intensive therapy (n = 63) or supportive care only (n = 80). Active salvage therapy (i.e., intensive or non-intensive therapy) resulted in a complete remission (CR) or CR without hematological recovery (CRi) rate of 42%. More patients achieved a CR/CRi with intensive (48%) compared with non-intensive (19%) salvage therapy (p < 0.001). In the overall population, median overall survival (OS) was 5.5 months; 1-and 5-year OS rates were 25% and 7%. OS was significantly (p <0.001) prolonged with intensive or non-intensive salvage therapy compared with supportive therapy, and in those achieving CR/CRi versus no responders. Of 280 evaluable patients, 61 (22%) had an allogeneic stem-cell transplant after they had achieved CR/CRi. In conclusion, in this large cohort study, salvage treatment approaches for patients with FLT3-ITD mutated R/R AML were heterogeneous. Median OS was poor with both non-intensive and intensive salvage therapy, with best long-term outcomes obtained in patients who achieved CR/CRi and subsequently underwent allogeneic stem-cell transplant