Desenvolvimento Tecnológico de Produtos Fitoterápicos

Made available in DSpace on 2017-06-01T18:21:25Z (GMT). No. of bitstreams: 2 license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) 6.pdf: 67168 bytes, checksum: 5768dc2aae847b6cc7b229cb5d58460f (MD5) Previous issue date: 7Universidade Federal do Rio Grande do Sul. Faculdade de Farmácia. Departamento de Produção e Controle de Medicamentos. Programa de Pós-graduação em Ciências Farmacêuticas. Grupo de Pesquisa Desenvolvimento Tecnológico de Produtos Farmacêuticos. Porto Alegre, RS, Brasil.Universidade Federal do Rio Grande do Sul. Faculdade de Farmácia. Departamento de Produção e Controle de Medicamentos. Programa de Pós-graduação em Ciências Farmacêuticas. Grupo de Pesquisa Desenvolvimento Tecnológico de Produtos Farmacêuticos. Porto Alegre, RS, Brasil.Universidade Federal do Rio Grande do Sul. Faculdade de Farmácia. Departamento de Produção e Controle de Medicamentos. Programa de Pós-graduação em Ciências Farmacêuticas. Grupo de Pesquisa Desenvolvimento Tecnológico de Produtos Farmacêuticos. Porto Alegre, RS, Brasil.A transformação de plantas medicinais em produtos com maior valor tecnológico agregado representa uma estratégia que pode contribuir para o progresso da sociedade. Neste trabalho, tomando como modelo um dos grupos de pesquisa existente no Brasil, são apresentados resultados focados no desenvolvimento tecnológico de produtos fitoterápicos oriundos da flora medicinal brasileira. Os exemplos demonstram a capacidade nacional em dominar matérias-primas complexas e os processos e fenômenos de sua transformação em produtos de potencial aplicação no mercado.Technological development of phytopharmaceutical products. The transformation of medicinal plants in products with high technological added value represents a strategic approach in order to promote social development. This article presents research results in the area of technological development of phytopharmaceutical products from Brazilian medicinal plants

Anti-inflammatory, antiallodynic effects and quantitative analysis of gallic acid in spray dried powders from Phyllanthus niruri leaves, stems, roots and whole plant

The anti-inflammatory and antiallodynic effects of spray dried powders starting from leaves, stems, roots, the mixture of leaves and stems, as well as the whole plant aqueous solutions of Phyllanthus niruri L., Phyllanthaceae, were assessed. Gallic acid, used as chemical marker, was quantified by HPLC in the spray dried powders. Carrageenan-induced inflammatory and allodynic responses in the mouse paw were used as pharmacological models. Quantitative and qualitative differences among chemical composition of different herb parts were observed. The oral administration of leaves or leaves plus stems spray dried powders (100 mg/kg) significantly inhibited the carrageenan-induced allodynic effect (42±5 and 54±3%, respectively). Additionally, the spray dried powders of leaves significantly reduced carrageenan-induced paw oedema (35±6%). The spray dried powders of roots, stems, or the mixture of leaves, stems and roots (100 mg/kg, p.o.) did not exhibit antiallodynic or antioedematogenic effect in the same model. In conclusion, differences in the chemical composition of spray dried powders from P. niruri are reflected in their in vivo pharmacological actions. Despite of a direct relationship of anti-inflammatory and antiallodynic effects with the gallic acid content had been observed, especially in the spray dried powders of leaves, the use of spray dried powders of leaves plus stems showed to be more effective, suggesting a synergic effect between their constituents

Caracterização de produto seco por aspersão de Vismia guianensis.

O objetivo do trabalho é a caracterização de produto seco por aspersão de Vismia guianensis com e sem aerosil

Anti-inflammatory and antinociceptive activities of Phyllanthus niruri spray-dried standardized extract

Phyllanthus niruri L., Euphorbiaceae, spray-dried standardized extract was studied for its anti-inflammatory and antinociceptive activities in adult albino rats and mice. The anti-inflammatory effect of spray-dried standardized extract was observed in carrageenan-induced paw edema and thioglycolate-induced leukocyte migration, while antinociceptive effects were observed using Randall & Selitto, tail flick, and hot plate tests. This study showed that intraperitoneal spray-dried standardized extract at 100, 200, 800, or 1600 mg/kg reduced the vascular response in the inflammatory process of paw edema induced by 1% carrageenan. Oral spray-dried standardized extract at 100 or 200 mg/kg inhibited leukocyte migration to the site of inflammation induced by 3% thioglycolate. In rats, at 100 and 200 mg/kg intraperitoneally, the extract exhibited a marked peripheral analgesic effect in a Randall & Selitto assay and showed significant central analgesic activity in a hot plate and tail flick assay. In conclusion, this study suggested that Phyllanthus niruri spray-dried standardized extract has potent inflammatory and antinociceptive activities and that these activities are not modified by standard drying process, making it feasible to use the dry extract standardized to obtain a phytotherapic preparation and thus validating its use for the treatment of pain and inflammation disorders