A theoretical and empirical study of the response of the high latitude thermosphere to the sense of the "Y" component of the interplanetary magnetic field

The strength and direction of the Interplanetary Magnetic Field (IMF) controls the transfer of solar wind momentum and energy to the high latitude thermosphere in a direct fashion. The sense of " Y" component of the IMF (BY) creates a significant asymmetry of the magnetospheric convection pattern as mapped onto the high latitude thermosphere and ionosphere. The resulting response of the polar thermospheric winds during periods when BY is either positive or negative is quite distinct, with pronounced changes in the relative strength of thermospheric winds in the dusk-dawn parts of the polar cap and in the dawn part of the auroral oval. In a study of four periods when there was a clear signature of BY, observed by the ISEE-3 satellite, with observations of polar winds and electric fields from the Dynamics Explorer-2 satellite and with wind observations by a ground-based Fabry-Perot interferometer located in Kiruna, Northern Sweden, it is possible to explain features of the high latitude thermospheric circulation using three dimensional global models including BY dependent, asymmetric, polar convection fields. Ground-based Fabry-Perot interferometers often observe anomalously low zonal wind velocities in the (Northern) dawn auroral oval during periods of extremely high geomagnetic activity when BY is positive. Conversely, for BY negative, there is an early transition from westward to southward and eastward winds in the evening auroral oval (excluding the effects of auroral substorms), and extremely large eastward (sunward) winds may be driven in the auroral oval after magnetic midnight. These observations are matched by the observation of strong anti-sunward polar-cap wind jets from the DE-2 satellite, on the dusk side with BY negative, and on the dawn side with BY positive.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/26311/1/0000396.pd

The GOAT-Ghrelin System Is Not Essential for Hypoglycemia Prevention during Prolonged Calorie Restriction

Ghrelin acylation by ghrelin O-acyltransferase (GOAT) has recently been reported to be essential for the prevention of hypoglycemia during prolonged negative energy balance. Using a unique set of four different genetic loss-of-function models for the GOAT/ghrelin/growth hormone secretagogue receptor (GHSR) system, we thoroughly tested the hypothesis that lack-of-ghrelin activation or signaling would lead to hypoglycemia during caloric deprivation. Male and female knockout (KO) mice for GOAT, ghrelin, GHSR, or both ghrelin and GHSR (dKO) were subjected to prolonged calorie restriction (40% of ad libitum chow intake). Body weight, fat mass, and glucose levels were recorded daily and compared to wildtype (WT) controls. Forty-eight hour blood glucose profiles were generated for each individual mouse when 2% or less body fat mass was reached. Blood samples were obtained for analysis of circulating levels of acyl- and desacyl-ghrelin, IGF-1, and insulin. Chronic calorie restriction progressively decreased body weight and body fat mass in all mice regardless of genotype. When fat mass was depleted to 2% or less of body weight for 2 consecutive days, random hypoglycemic events occurred in some mice across all genotypes. There was no increase in the incidence of hypoglycemia in any of the four loss-of-function models for ghrelin signaling including GOAT KO mice. Furthermore, no differences in insulin or IGF-1 levels were observed between genotypes. The endogenous GOAT-ghrelin-GHSR system is not essential for the maintenance of euglycemia during prolonged calorie restriction

Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status

BACKGROUND: Macrophages play a dual role in multiple sclerosis (MS) pathology. They can exert neuroprotective and growth promoting effects but also contribute to tissue damage by production of inflammatory mediators. The effector function of macrophages is determined by the way they are activated. Stimulation of monocyte-derived macrophages in vitro with interferon-γ and lipopolysaccharide results in classically activated (CA/M1) macrophages, and activation with interleukin 4 induces alternatively activated (AA/M2) macrophages. METHODS: For this study, the expression of a panel of typical M1 and M2 markers on human monocyte derived M1 and M2 macrophages was analyzed using flow cytometry. This revealed that CD40 and mannose receptor (MR) were the most distinctive markers for human M1 and M2 macrophages, respectively. Using a panel of M1 and M2 markers we next examined the activation status of macrophages/microglia in MS lesions, normal appearing white matter and healthy control samples. RESULTS: Our data show that M1 markers, including CD40, CD86, CD64 and CD32 were abundantly expressed by microglia in normal appearing white matter and by activated microglia and macrophages throughout active demyelinating MS lesions. M2 markers, such as MR and CD163 were expressed by myelin-laden macrophages in active lesions and perivascular macrophages. Double staining with anti-CD40 and anti-MR revealed that approximately 70% of the CD40-positive macrophages in MS lesions also expressed MR, indicating that the majority of infiltrating macrophages and activated microglial cells display an intermediate activation status. CONCLUSIONS: Our findings show that, although macrophages in active MS lesions predominantly display M1 characteristics, a major subset of macrophages have an intermediate activation status

PSI - Problem Solving Inventory (scheda descrittiva)

Test psicologico. Scheda descrittiva creata all'interno del progetto Bibliomedi