Poder do Estado na sociedade moderna: os problemas de compreensão e investigação

The article analyzes the problems associated with the understanding of state power, as well as theoretical and methodological innovations and research tools used in the study of this political and legal phenomenon. The authors analyze various directions of the legal, political and sociocultural definition of state power, identify and discuss various dimensions and levels in the conceptualization of the latter. In the context of the paper, the government is as a complex political and legal phenomenon, considered as a specific type of general system of public authority, which is implemented by various political subjects, which have a rigid link to the socio-cultural and territorial space.El artículo analiza los problemas asociados con la comprensión del poder estatal, así como las innovaciones teóricas y metodológicas y las herramientas de investigación utilizadas en el estudio de este fenómeno político y legal. Los autores analizan varias direcciones de la definición legal, política y sociocultural del poder estatal, identifican y discuten varias dimensiones y niveles en la conceptualización de este último. En el contexto del documento, el gobierno es como un fenómeno político y legal complejo, considerado como un tipo específico de sistema general de autoridad pública, que es implementado por varios sujetos políticos, que tienen un vínculo rígido con el contexto sociocultural y territorial. espacio.O artigo analisa os problemas associados à compreensão do poder do Estado, bem como as inovações teóricas e metodológicas e ferramentas de pesquisa utilizadas no estudo desse fenômeno político e jurídico. Os autores analisam várias direções da definição jurídica, política e sociocultural do poder do Estado, identificam e discutem várias dimensões e níveis na conceituação do último. No contexto do trabalho, o governo é um fenômeno político e jurídico complexo, considerado como um tipo específico de sistema geral de autoridade pública, que é implementado por vários sujeitos políticos, que têm um vínculo rígido com as relações socioculturais e territoriais. espaço

Esophageal Hemorrhagic Syndromes

Esophageal  bleeding is  one of  the most  common medical emergencies. It takes  the  3rd place among  all digestive hemorrhages, and accounts for 14–16 % among all gastrointestinal bleeding. The most common cause of esophageal hemorrhages is Mallory – Weiss esophageal tear (10–12 %), less often – varicose veins of the esophagus in portal hypertension syndrome (up to 4 %) and, in some cases, is esophagitis of various etiologies (up to 1.6 %). The problem of  esophageal  bleeding  is  characterized  by  high  incidence,  high  mortality  rate  due  to  constant  increase  of  portal hyper tension cases, recurrences, difficulties in diagnosis, anatomical and physiological features of the esophagus, low efficiency of the main methods of hemostasis. There are various surgical and conservative methods of hemostasis, which show a variety of opinions in the solution to the problem of stopping esophageal bleeding. In Mallory – Weiss syndrome, endoscopic hemostasis is considered to be the preferred method of treatment. Management of portal hypertension is the most difficult task; a wide range of operations is used from the minimally invasive operations to the liver transplantation, as well as endoscopic hemostasis (ligation, sclerotherapy). In esophageal bleeding, due to reflux esophagitis, mainly conservative treatment is suggested, operations are performed with recurrences or complications. Each kind of esophageal hemorrhage is considered as a separate problem

Development of a methodology for molecular genetic monitoring for the cholera causative agent

Background. The ongoing cholera pandemic determines the relevance of the development and improvement of methods for analysis of data on genome-wide sequencing of the cholera pathogen. This is of particular importance in the light of the challenges of import substitution of foreign products, including software. The aim of the study was to develop a methodology for molecular genetic monitoring for the cholera causative agent using online geographic information system (GIS) and analysis with its help of strains isolated in Russia earlier. Materials and methods. Data from genome-wide sequencing of 2598 toxigenic (ctxAB+tcpA+) strains of V. cholerae O1 El Tor, both obtained by the authors on the MiSeq (Illumina) platform, and retrieved from the NCBI database were used in the study. The SNP analysis software was developed in the Java and Python programming languages. Cytoscape program was used to visualize the dendrogram. The development of online GIS was carried out using the programming languages HTML, JavaScript and PHP. The freely distributed Leaflet library written in JavaScript was used as the core. Maps obtained from the OpenStreetMap community were used as cartographic data. Results and discussion. A universal set of SNPs and software have been developed to analyze the data of genome-wide sequencing of cholera vibrio strains. It was shown that the majority of strains were distributed among several large clusters. The most closely related strains for cholera vibrions isolated in Russia since 2001 have been identified. An online GIS "Molecular genetic monitoring for V. cholerae" has been created, which allows the recognition of closely related strains directly on an electronic map

USAGE OF GIS-TECHNOLOGIES BASED ON THE SPATIAL ANALYSIS FOR DEVELOPMENT OF THE RISK ASSESSMENT TECHNIQUES OF POTENTIAL HAZARD OF ROSTOV REGION‘S TERRITORIES DUE TO ANTHRAX

Purpose: to develop the methodology for risk-assessment of the potential hazard of the Rostov region’s territory due to anthrax based on the spatial analysis, independent of the administrative division.Materials and Methods: for development the risk-based assessment of potential hazards of territory due to anthrax the registration data of cases for 132 years have been used. The construction of risk cartograms were carried out on the basis of biweight distribution of stationary unfavorable places due to anthrax.Results: the average value of the epizootic index and density of stationary unfavorable places due to anthrax are calculated for 413 administrative units of the Rostov region.Summary: the identification of «risk areas» by using risk-based methodology would provide the more accurate results than the zoning due to administrative territories

O1 Serogroup Cholera Vibrios Isolated from the Rostov-on-Don Water Bodies in the Course of Surveillance in 2008–2012

Identified are the peculiarities of biological properties and origin of cholera vibrio O1 serogroup strains isolated from the Rostov-on-Don water bodies in the course of surveillance in 2008–2012. 41 atoxigenic V. cholerae O1 strains have been isolated from 767 water samples and investigated. Stable tendency of isolation of increased numbers of atoxigenic V. cholerae O1 strains over time has been demonstrated. In addition, in the strains under study detected have been the genes of additional pathogenicity factors, by PCR genotyping using specific primers for 45 nucleotide sequences associated with V. cholerae pathogenicity. The strains have also been classified according to 19 VNTR-genotypes grouped into 6 clusters based on VNTR-typing using exclusive copyright locus-specific primers. Discovered have been the strains with similar genotypes though isolated at different points both throughout the year and over the period of several years. These ones have probably been imported. They are characterized by a capacity to persist in ambient water bodies for a certain period of time

Mesopause region semidiurnal tide over Europe as seen from ground-based wind measurements

Wind measurements carried out at 6 European sites are investigated to set up a climatology of the semidiurnal tide in the mesopause region over Europe for the latitudinal range between 50°N and 56°N. Intercomparison of amplitudes and phases generally shows good agreement of the results from the different measuring systems. The longitudinal variation of the semidiurnal tide is small. The results are compared with an empirical model of the semidiurnal tide

SAGES consensus recommendations on an annotation framework for surgical video

Background: The growing interest in analysis of surgical video through machine learning has led to increased research efforts; however, common methods of annotating video data are lacking. There is a need to establish recommendations on the annotation of surgical video data to enable assessment of algorithms and multi-institutional collaboration. Methods: Four working groups were formed from a pool of participants that included clinicians, engineers, and data scientists. The working groups were focused on four themes: (1) temporal models, (2) actions and tasks, (3) tissue characteristics and general anatomy, and (4) software and data structure. A modified Delphi process was utilized to create a consensus survey based on suggested recommendations from each of the working groups. Results: After three Delphi rounds, consensus was reached on recommendations for annotation within each of these domains. A hierarchy for annotation of temporal events in surgery was established. Conclusions: While additional work remains to achieve accepted standards for video annotation in surgery, the consensus recommendations on a general framework for annotation presented here lay the foundation for standardization. This type of framework is critical to enabling diverse datasets, performance benchmarks, and collaboration

Cholera Forecast for the Year 2019 Based on Assessment of Epidemiological Situation Around the World, Across CIS and Russia in 2009–2018

Analysis of cholera incidence for the period of 2009–2018 was performed. The upward tendency in the morbidity rate dynamics around the world (compared to 2009) with an average annual growth rate of 5,352 % was revealed. For the first time during the 7th pandemic caused by V. cholerae O1 El Tor, WHO reported 1227391 cases of cholera world-wide in 2017, out of which 1032481 (84.1%) were registered in Yemen, where the war continues and one of the largest epidemics in the world. There have been cross-border epidemiological complications in several African countries. Endemic foci continue to exist and spread in Asia, Africa and the Caribbean. Under the epidemiological surveillance in Russia, 744 strains of V. cholerae El Tor – ctxA– tcpA–, ctxA– tcpA+ and V. cholerae О139 ctxA– and tcpA– were isolated from the surface water bodies, as well as single strains of El Tor ctxA+ tcpA+. As a result of INDEL- and  PCR-genotyping, the isolation of strains with identical genotypes and new ones was established. To make the prognosis for 2019, the risk of activation (continuation) of the cholera epidemic process in the world was assessed, taking into account emergencies of different origin and risk factors. The cholera forecast at the global level and in  Russia for 2019 is unfavorable

Study of low-energy nuclear recoils in liquid argon with the ReD experiment

Liquid Argon (LAr) Time Projection Chambers (TPC) operating in double-phase can detect the nuclear recoils (NR) possibly caused by the elastic scattering of WIMP dark matter particles via light signals from both scintillation and ionization processes. In the scenario of a low-mass WIMP (< 2 GeV/c2), the energy range for the NRs would be below 20 keV, thus making it crucial to characterize the ionization response in LAr TPCs as the lone available detection channel at such low energy. The Recoil Directionality (ReD) project, within the Global Argon Dark Matter Collaboration, aims to measure the ionization yield of a LAr TPC in the recoil energy range of 2-5 keV. The measurement was performed in winter 2023 at the INFN Sezione of Catania and the analysis is ongoing