180 research outputs found
Influence of damping on the excitation of the double giant resonance
We study the effect of the spreading widths on the excitation probabilities
of the double giant dipole resonance. We solve the coupled-channels equations
for the excitation of the giant dipole resonance and the double giant dipole
resonance. Taking Pb+Pb collisions as example, we study the resulting effect on
the excitation amplitudes, and cross sections as a function of the width of the
states and of the bombarding energy.Comment: 8 pages, 3 figures, corrected typo
First principles calculation of structural and magnetic properties for Fe monolayers and bilayers on W(110)
Structure optimizations were performed for 1 and 2 monolayers (ML) of Fe on a
5 ML W(110) substrate employing the all-electron full-potential linearized
augmented plane-wave (FP-LAPW) method. The magnetic moments were also obtained
for the converged and optimized structures. We find significant contractions
( 10 %) for both the Fe-W and the neighboring Fe-Fe interlayer spacings
compared to the corresponding bulk W-W and Fe-Fe interlayer spacings. Compared
to the Fe bcc bulk moment of 2.2 , the magnetic moment for the surface
layer of Fe is enhanced (i) by 15% to 2.54 for 1 ML Fe/5 ML W(110), and
(ii) by 29% to 2.84 for 2 ML Fe/5 ML W(110). The inner Fe layer for 2
ML Fe/5 ML W(110) has a bulk-like moment of 2.3 . These results agree
well with previous experimental data
Work-family conflicts and self-reported work ability: cross-sectional findings in women with chronic musculoskeletal disorders
Work-related medical rehabilitation in patients with musculoskeletal disorders: the protocol of a propensity score matched effectiveness study (EVA-WMR, DRKS00009780)
Severe hematotoxicity after CD19 CAR-T therapy is associated with suppressive immune dysregulation and limited CAR-T expansion
Prolonged cytopenias after chimeric antigen receptor (CAR) T cell therapy are a significant clinical problem and the underlying pathophysiology remains poorly understood. Here, we investigated how (CAR) T cell expansion dynamics and serum proteomics affect neutrophil recovery phenotypes after CD19-directed CAR T cell therapy. Survival favored patients with "intermittent" neutrophil recovery (e.g., recurrent neutrophil dips) compared to either "quick" or "aplastic" recovery. While intermittent patients displayed increased CAR T cell expansion, aplastic patients exhibited an unfavorable relationship between expansion and tumor burden. Proteomics of patient serum collected at baseline and in the first month after CAR-T therapy revealed higher markers of endothelial dysfunction, inflammatory cytokines, macrophage activation, and T cell suppression in the aplastic phenotype group. Prolonged neutrophil aplasia thus occurs in patients with systemic immune dysregulation at baseline with subsequently impaired CAR-T expansion and myeloid-related inflammatory changes. The association between neutrophil recovery and survival outcomes highlights critical interactions between host hematopoiesis and the immune state stimulated by CAR-T infusion
Current Accounts in Europe: Implications of the External Imbalances for the Future of the Common Monetary Policy
A web-based intervention to promote applications for rehabilitation: a study protocol for a randomized controlled trial
A bio-psycho-social exercise program (RÜCKGEWINN) for chronic low back pain in rehabilitation aftercare - Study protocol for a randomised controlled trial
<p>Abstract</p> <p>Background</p> <p>There is strong, internationally confirmed evidence for the short-term effectiveness of multimodal interdisciplinary specific treatment programs for chronic back pain. However, the verification of long-term sustainability of achieved effects is missing so far. For long-term improvement of pain and functional ability high intervention intensity or high volume seems to be necessary (> 100 therapy hours). Especially in chronic back pain rehabilitation, purposefully refined aftercare treatments offer the possibility to intensify positive effects or to increase their sustainability. However, quality assured goal-conscious specific aftercare programs for the rehabilitation of chronic back pain are absent.</p> <p>Methods/Design</p> <p>This study aims to examine the efficacy of a specially developed bio-psycho-social chronic back pain specific aftercare intervention (RÜCKGEWINN) in comparison to the current usual aftercare (IRENA) and a control group that is given an educational booklet addressing pain-conditioned functional ability and back pain episodes. Overall rehabilitation effects as well as predictors for compliance to the aftercare programs are analysed. Therefore, a multicenter prospective 3-armed randomised controlled trial is conducted. 456 participants will be consecutively enrolled in inpatient and outpatient rehabilitation and assigned to either one of the three study arms. Outcomes are measured before and after rehabilitation. Aftercare programs are assessed at ten month follow up after dismissal form rehabilitation.</p> <p>Discussion</p> <p>Special methodological and logistic challenges are to be mastered in this trial, which accrue from the interconnection of aftercare interventions to their residential district and the fact that the proportion of patients who take part in aftercare programs is low. The usability of the aftercare program is based on the transference into the routine care and is also reinforced by developed manuals with structured contents, media and material for organisation assistance as well as training manuals for therapists in the aftercare.</p> <p>Trial Registration</p> <p>Trial Registration number: NCT01070849</p
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