7 research outputs found
Fishery resources of the Exclusive Economic Zone of the northwest coast of India
For well over two decades now, trawling operations,
both exploratory and commercial, have been going on
along the north-western region, off the Goa, Maha
rashtra and Gujarat coasts (15°-24°N). A historical
resimie of trawling in India has been given by Jayaraman
et al. (1959) in their account of the demersal fishery
resources of the shelf waters of this area, for the period
1950 to 1955. Similar accoimts on the distribution
patterns of major exploited fisheries for 1961-1967 and
1968-1970, have been given by Rao (1969) and
Rao et al. (1966, 1972) and Nair (1974). Apart from
the above accoimts on the fisheries in general, detailed
studies on the pattern of distribution and abundance
of individual species have been reported by Rao (1965—
Pseudosciaena' diacanthus), Kagwade (1973—Polynemus
heptadactylus), Deshmukh (1973—Pomadasys hasta),
Kaikini (1974—Lactarius lactarius) and Kagwade
{1966—prawns), as also (Prabhu and Dhawan, 1974)—
regional fisheries off Goa. The results of these
studies, based on bottom-trawling operations mostly
in regions less than 80 metres in depth, have given us a
fair knowledge of the demersal resources potential of
this region
Cellular Fitness Phenotypes of Cancer Target Genes from Oncobiology to Cancer Therapeutics
To define the growing significance of cellular targets and/or effectors of cancer drugs, we examined the fitness dependency of cellular targets and effectors of cancer drug targets across human cancer cells from 19 cancer types. We observed that the deletion of 35 out of 47 cellular effectors and/or targets of oncology drugs did not result in the expected loss of cell fitness in appropriate cancer types for which drugs targeting or utilizing these molecules for their actions were approved. Additionally, our analysis recognized 43 cellular molecules as fitness genes in several cancer types in which these drugs were not approved, and thus, providing clues for repurposing certain approved oncology drugs in such cancer types. For example, we found a widespread upregulation and fitness dependency of several components of the mevalonate and purine biosynthesis pathways (currently targeted by bisphosphonates, statins, and pemetrexed in certain cancers) and an association between the overexpression of these molecules and reduction in the overall survival duration of patients with breast and other hard-to-treat cancers, for which such drugs are not approved. In brief, the present analysis raised cautions about off-target and undesirable effects of certain oncology drugs in a subset of cancers where the intended cellular effectors of drug might not be good fitness genes and that this study offers a potential rationale for repurposing certain approved oncology drugs for targeted therapeutics in additional cancer types