Vortical and Wave Modes in 3D Rotating Stratified Flows: Random Large Scale Forcing

Utilizing an eigenfunction decomposition, we study the growth and spectra of energy in the vortical and wave modes of a 3D rotating stratified fluid as a function of $\epsilon = f/N$. Working in regimes characterized by moderate Burger numbers, i.e. $Bu = 1/\epsilon^2 < 1$ or $Bu \ge 1$, our results indicate profound change in the character of vortical and wave mode interactions with respect to $Bu = 1$. As with the reference state of $\epsilon=1$, for $\epsilon < 1$ the wave mode energy saturates quite quickly and the ensuing forward cascade continues to act as an efficient means of dissipating ageostrophic energy. Further, these saturated spectra steepen as $\epsilon$ decreases: we see a shift from $k^{-1}$ to $k^{-5/3}$ scaling for $k_f < k < k_d$ (where $k_f$ and $k_d$ are the forcing and dissipation scales, respectively). On the other hand, when $\epsilon > 1$ the wave mode energy never saturates and comes to dominate the total energy in the system. In fact, in a sense the wave modes behave in an asymmetric manner about $\epsilon = 1$. With regard to the vortical modes, for $\epsilon \le 1$, the signatures of 3D quasigeostrophy are clearly evident. Specifically, we see a $k^{-3}$ scaling for $k_f < k < k_d$ and, in accord with an inverse transfer of energy, the vortical mode energy never saturates but rather increases for all $k < k_f$. In contrast, for $\epsilon > 1$ and increasing, the vortical modes contain a progressively smaller fraction of the total energy indicating that the 3D quasigeostrophic subsystem plays an energetically smaller role in the overall dynamics.Comment: 18 pages, 6 figs. (abbreviated abstract

Non-Gaussian Distributions in Extended Dynamical Systems

We propose a novel mechanism for the origin of non-Gaussian tails in the probability distribution functions (PDFs) of local variables in nonlinear, diffusive, dynamical systems including passive scalars advected by chaotic velocity fields. Intermittent fluctuations on appropriate time scales in the amplitude of the (chaotic) noise can lead to exponential tails. We provide numerical evidence for such behavior in deterministic, discrete-time passive scalar models. Different possibilities for PDFs are also outlined.Comment: 12 pages and 6 figs obtainable from the authors, LaTex file, OSU-preprint-

Simplifying syntactic and semantic parsing of NL-based queries in advanced application domains

The paper presents a high level query language (MDDQL) for databases, which relies on an ontology driven automaton. This is simulated by the human-computer interaction mode for the query construction process, which is driven by an inference engine operating upon a frames based ontology description. Therefore, given that the query construction process implicitly leads to the contemporary construction of high level query trees prior to submission of the query for transformation and execution to a semantic middle-ware, syntactic and semantic parsing of a query with conventional techniques, i.e., after completion of its formulation, becomes obsolete. To this extent, only, as meaningful as possible, queries can be constructed at a low typing, learning, syntactic and semantic parsing effort and regardless the preferred natural (sub)language. From a linguistics point o view, it turns out that the query construction mechanism can easily be adapted and work with families of natural languages, which underlie another type order such as Subject-Object-Verb as opposed to the typical Subject-Verb-Object type order, which underlie most European languages. The query construction mechanism has been proved as practical in advanced application domains, such as those provided by medical applications, with an advanced and hardly understood terminology for naive users and the public

Phosphorylation of the Leukemic Oncoprotein EVI1 on Serine 196 Modulates DNA Binding, Transcriptional Repression and Transforming Ability

The EVI1 (ecotropic viral integration site 1) gene at 3q26 codes for a transcriptional regulator with an essential role in haematopoiesis. Overexpression of EVI1 in acute myeloid leukaemia (AML) is frequently associated with 3q26 rearrangements and confers extremely poor prognosis. EVI1 mediates transcriptional regulation, signalling, and epigenetic modifications by interacting with DNA, proteins and protein complexes. To explore to what extent protein phosphorylation impacts on EVI1 functions, we analysed endogenous EVI1 protein from a high EVI1 expressing Fanconi anaemia (FA) derived AML cell line. Mass spectrometric analysis of immunoprecipitated EVI1 revealed phosphorylation at serine 196 (S196) in the sixth zinc finger of the N-terminal zinc finger domain. Mutated EVI1 with an aspartate substitution at serine 196 (S196D), which mimics serine phosphorylation of this site, exhibited reduced DNA-binding and transcriptional repression from a gene promotor selectively targeted by the N-terminal zinc finger domain. Forced expression of the S196D mutant significantly reduced EVI1 mediated transformation of Rat1 fibroblasts. While EVI1-mediated serial replating of murine haematopoietic progenitors was maintained by EVI1-S196D, this was associated with significantly higher Evi1-trancript levels compared with WT-EVI1 or EVI1-S196A, mimicking S196 non-phosphorylated EVI1. These data suggest that EVI1 function is modulated by phosphorylation of the first zinc finger domain

Variations of plasma enzyme activities and inflammation markers in severe head injury: a multivariate approach for patient monitoring and outcome prediction.

peer reviewe

investigations on crack propagation under cyclical isothermal and thermo-mechanical loadings for a type 304-l stainless steel used for pressurized water reactor

International audienceThe integrity of structures exhibiting flaws in Pressurized Water Reactor (PWR) has to be assessed to meet safety criteria. This paper deals with crack-propagation under cyclic thermo-mechanical loadings, as encountered in class I austenitic pipes of PWR's. To this end, a device called PROFATH was designed. The specimen is a pre-cracked thick-walled tube undergoing a set of thermal cycles and loaded with a static mechanical force. During the first part of the cycle, a high frequency induction coil heats the external wall. Then, the heating system stops and the specimen is cooled down by running water inside the tube. Finite element calculations show that only a region half-way along the tube should be heated to ensure adequate structural effect. In the heated zone, the machining of a sharp circumferential groove ensures the propagation of a unique crack. An electro-mechanical jack controls the level of the mechanical static load. To obtain a very precise thermal mapping, a specific specimen with dedicated instrumentation is used: 20 thermocouples are appropriately located on the outer surface and along the wall thickness. During the test, the crack-propagation is estimated through crack-opening measurements (compliance method). Now, tests have been carried out at different levels of thermo-mechanical loadings. These tests allow having an evaluation of the pertinence of the correction proposed by the RSE-M for a significant plasticity. And these tests can also be used to have a confirmation or to propose an extension of the validity domain