MS-122: Civil War Institute Collection

This collection contains two different types of materials. Series I contains materials relating to the Civil War in general, and are organized by subject. Series II and III contain materials or records pertaining directly to the Civil War Conferences and the Civil War Institute from 1957 – 1963. Special Collections and College Archives Finding Aids are discovery tools used to describe and provide access to our holdings. Finding aids include historical and biographical information about each collection in addition to inventories of their content. More information about our collections can be found on our website http://www.gettysburg.edu/special_collections/collections/.https://cupola.gettysburg.edu/findingaidsall/1110/thumbnail.jp

Improving estimates of the number of fake leptons and other mis-reconstructed objects in hadron collider events: BoB's your UNCLE. (Previously "The Matrix Method Reloaded")

We consider current and alternative approaches to setting limits on new physics signals having backgrounds from misidentified objects; for example jets misidentified as leptons, b-jets or photons. Many ATLAS and CMS analyses have used a heuristic matrix method for estimating the background contribution from such sources. We demonstrate that the matrix method suffers from statistical shortcomings that can adversely affect its ability to set robust limits. A rigorous alternative method is discussed, and is seen to produce fake rate estimates and limits with better qualities, but is found to be too costly to use. Having investigated the nature of the approximations used to derive the matrix method, we propose a third strategy that is seen to marry the speed of the matrix method to the performance and physicality of the more rigorous approach.Comment: v1 :11 pages, 5 figures. v2: title change requested by referee, and other corrections/clarifications found during review. v3: final tweaks suggested during review + move from revtex to jhep styl

Chemical application of diffusion quantum Monte Carlo

The diffusion quantum Monte Carlo (QMC) method gives a stochastic solution to the Schroedinger equation. This approach is receiving increasing attention in chemical applications as a result of its high accuracy. However, reducing statistical uncertainty remains a priority because chemical effects are often obtained as small differences of large numbers. As an example, the single-triplet splitting of the energy of the methylene molecule CH sub 2 is given. The QMC algorithm was implemented on the CYBER 205, first as a direct transcription of the algorithm running on the VAX 11/780, and second by explicitly writing vector code for all loops longer than a crossover length C. The speed of the codes relative to one another as a function of C, and relative to the VAX, are discussed. The computational time dependence obtained versus the number of basis functions is discussed and this is compared with that obtained from traditional quantum chemistry codes and that obtained from traditional computer architectures

High spatial resolution studies of galaxies in the far IR: Observations with the KAO, and the promise of SOFIA

NASA, in collaboration with the West German Science Ministry (BMFT), plans a larger airborne telescope as a successor to the Kuipper Airborne Observatory (KAO) that will achieve these goals. The Stratospheric Observatory for Infrared Astronomy (SOFIA) is entering the final stages of Phase B review with targeted new start early in the next decade. SOFIA is a 2.7 m diameter telescope that is carried in a Boeing 747SP. In addition to having 3 times the spatial resolution of the KAO, and 10 times the light gathering power, it will incorporate improvements over the KAO in lower optical emissivity and better telescope tracking stability. The thin primary mirror will equilibrate quickly to ambient temperature at an altitude which, accompanied by airflow improvements across the telescope cavity, will result in better image quality. The sensitivity of SOFIA will allow us to see a large number of typical bright galactic HII regions in local group galaxies. The spatial resolution of 8 seconds (full width half maximum Airy disk) at 100 microns will allow these regions to be measured independently, if they are distributed similarly to those in our own galaxy. At this spatial resolution, the disks of normal galaxies will be easily resolved out to distances of several hundred Mpc. This portion of space includes many of the superluminous galaxies discovered by the Infrared Astronomy Satellite (IRAS), and this spatial scale is relevant for studies of the morphology of regions of interaction among the majority of these galaxies that are members of colliding pairs

POPCORN: a Supervisory Control Simulation for Workload and Performance Research

A multi-task simulation of a semi-automatic supervisory control system was developed to provide an environment in which training, operator strategy development, failure detection and resolution, levels of automation, and operator workload can be investigated. The goal was to develop a well-defined, but realistically complex, task that would lend itself to model-based analysis. The name of the task (POPCORN) reflects the visual display that depicts different task elements milling around waiting to be released and pop out to be performed. The operator's task was to complete each of 100 task elements that ere represented by different symbols, by selecting a target task and entering the desired a command. The simulated automatic system then completed the selected function automatically. Highly significant differences in performance, strategy, and rated workload were found as a function of all experimental manipulations (except reward/penalty)

Reducing latency when using Virtual Reality for teaching in sport

Latency is a frequently cited shortcoming of Virtual Reality (VR) applications. To compensate for excessive latency, prediction mechanisms may use sophisticated mathematical algorithms, which may not be appropriate for complex virtual teaching applications. This paper suggests that heuristic prediction algorithms could be used to develop more effective and general systems for VR educational applications. A fast synchronization squash simulation illustrates where heuristic prediction can be used to deal with latency problems

Correction to the pathogenic alternative splicing, caused by the common GNB3 c.825C>T allele, using a novel, antisense morpholino

The very common GNB3 c.825C>T polymorphism (rs5443), is present in approximately half of all human chromosomes. Significantly the presence of the GNB3 825T allele has been strongly associated, with predisposition to essential hypertension. Paradoxically the presence of the GNB3 825T allele, in exon 10, introduces a pathogenic alternative RNA splice site into the middle of exon 9. To attempt to correct this pathogenic aberrant splicing, we therefore bioinformatically designed, using a Gene Tools® algorithm, a GNB3 specific, antisense morpholino. It was hoped that this morpholino would behave in vitro as either a potential “ splice blocker and/or exon skipper, to both bind and inhibit/reduce the aberrant splicing of the GNB3, 825T allele. On transfecting a human lymphoblast cell line homozygous for the 825T allele, with this antisense morpholino, we encouragingly observed both a significant reduction (from ~58% to ~5%) in the production of the aberrant smaller GNB3 transcript, and a subsequent increase in the normal GNB3 transcript (from ~42% to ~95%). Our results demonstrate the potential use of a GNB3 specific antisense morpholino, as a pharmacogenetic therapy for essential hypertension

A Stereochemical Test of a Proposed Structural Feature of the Nicotinic Acetylcholine Receptor

Understanding the gating mechanism of the nicotinic acetylcholine receptor (nAChR) and similar channels constitutes a significant challenge in chemical neurobiology. In the present work, we use a stereochemical probe to evaluate a proposed pin-into-hydrophobic socket mechanism for the αVal46 side chain of the nAChR. Utilizing nonsense suppression methodology we incorporated isoleucine (Ile), O-methyl threonine (Omt) and threonine (Thr) as well as their side chain epimers (the allo counterparts). Surprisingly, our results indicate that only the pro-S methyl group of the αVal46 side chain is sensitive to changes in hydrophobicity, consistent with the precise geometrical requirements of the pin-into-socket mechanism

Pedagogical Feedback for Computer-based Sport Training

Feedback in Computer-based Sport Training (CBST) may be synthetically designed to allow athletes to practise in a more effective way and enhance their skill acquisition. Little research has integrated pedagogic theory and instructional design with the design of feedback in CBST. To bridge this gap, the paper presents the design of pedagogically-informed feedback for the implementation of a CBST system. The heart of the design is to generate feedback based on the athletes’ achievement of their intended training outcome. The pedagogical feedback system measures athletes’ performance and compares it with the given training outcomes. The system then identifies the performance’s gap and generates feedback to reinforce better performance. A Counterbalanced experiment asked student rowers (N = 8) to explore the differences between the pedagogical feedback system and their current feedback system (Sean-Analysis). Pedagogical feedback was at least as good as Sean-Analysis with respect to the level of satisfaction of the athlete. Overall, it can be concluded that the pedagogical feedback appears to be a good model for generating feedback in CBST