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Patient-Related Barriers to Timely Dialysis Access Preparation: A Qualitative Study of the Perspectives of Patients, Family Members, and Health Care Providers
Rational & Objective
A key aspect of smooth transition to dialysis is the timely creation of a permanent access. Despite early referral to kidney care, initiation onto dialysis is still suboptimal for many patients, which has clinical and cost implications. This study aimed to explore perspectives of various stakeholders on barriers to timely access creation.
Study Design
Qualitative study.
Setting & Participants
Semi-structured interviews with 96 participants (response rate, 67%), including patients with stage 4 chronic kidney disease (n = 30), new hemodialysis patients with (n = 18) and without (n = 20) permanent access (arteriovenous fistula), family members (n = 19), and kidney health care providers (n = 9).
Analytical Approach
Thematic analysis.
Results
Patients reported differential levels of behavioral activation toward access creation: avoidance/denial, wait and see, or active intention. 6 core themes were identified: (1) lack of symptoms, (2) dialysis fear and practical concerns (exaggerated fear, pain, cost, lifestyle disruptions, work-related concerns, burdening their families), (3) evaluating value against costs/risks of access creation (benefits, threat of operation, viability, prompt for early initiation), (4) preference for alternatives, (5) social influences (hearsay, family involvement, experiences of others), and (6) health care provider interactions (mistrust, interpersonal tension, lack of clarity on information). Themes were common to all groups, whereas nuanced perspectives of family members and health care providers were noted in some subthemes.
Limitations
Response bias.
Conclusions
Individual, interpersonal, and psychosocial factors compromise dialysis preparation and contribute to suboptimal dialysis initiation. Our findings support the need for interventions to improve patient and family engagement and address emotional concerns and misperceptions about preparing for dialysis
A Longitudinal Study of Streptococcus mutans Colonization in Infants after Tooth Eruption
We previously reported that, before tooth eruption, over one-half of infants aged 6 mos were already infected with Streptococcus mutans. The aim of this investigation was to determine the colonization of S. mutans after tooth eruption in the same cohort of 111 infants (35 pre-term, 76 full-term). Our results showed that S. mutans colonization increased with increasing age, so that by 24 mos of age, 84% harbored the bacteria (p 10(5) CFU/mL (p < 0.02). In contrast, non-colonization of S. mutans was associated with toothbrushing (p < 0.03) and multiple courses of antibiotics (p < 0.001). Analysis of our data establishes the timing of S. mutans colonization in children from birth to 24 mos of age
Smoking cessation and lung cancer risk in an Asian population: Findings from the Singapore Chinese Health Study
10.1038/sj.bjc.6605782British Journal of Cancer10371093-1096BJCA
Longitudinal Current Dissipation in Bose-glass Superconductors
A scaling theory of vortex motion in Bose glass superconductors with currents
parallel to the common direction of the magnetic field and columnar defects is
presented. Above the Bose-glass transition the longitudinal DC resistivity
vanishes much faster than the
corresponding transverse resistivity , thus {\it reversing} the usual anisotropy of electrical transport in
the normal state of layered superconductors. In the presence of a current at an angle with the common field and columnar defect axis, the
electric field angle approaches as .
Scaling also predicts the behavior of penetration depths for the AC currents as
, and implies a {\it jump discontinuity} at in
the superfluid density describing transport parallel to the columns.Comment: 5 pages, revte
Distributed Supervisory Control of Discrete-Event Systems with Communication Delay
This paper identifies a property of delay-robustness in distributed
supervisory control of discrete-event systems (DES) with communication delays.
In previous work a distributed supervisory control problem has been
investigated on the assumption that inter-agent communications take place with
negligible delay. From an applications viewpoint it is desirable to relax this
constraint and identify communicating distributed controllers which are
delay-robust, namely logically equivalent to their delay-free counterparts. For
this we introduce inter-agent channels modeled as 2-state automata, compute the
overall system behavior, and present an effective computational test for
delay-robustness. From the test it typically results that the given delay-free
distributed control is delay-robust with respect to certain communicated
events, but not for all, thus distinguishing events which are not
delay-critical from those that are. The approach is illustrated by a workcell
model with three communicating agents
The effects of chlorhexidine gel on Streptococcus mutans infection in 10-month-old infants: A longitudinal, placebo-controlled, double-blind trial
This study investigated the long-term effects of 0.2% chlorhexidine gel, used as a weekly brush-on gel, on Streptoccocus mutans infection in 10-month-old infants.The investigation followed the criteria of a placebo-controlled, double-blind, longitudinal clinical trial. Infants were recruited at birth and oral microbiological swabs were taken at 3 monthly intervals, together with medical, dental, dietary and brushing histories. Children who were found to be colonized with S. mutans were randomly assigned to either the chlorhexidine-gel group (N = 50) or placebo gel group (N = 46), and parents were instructed to brush the gel on the teeth once per week for 12 weeks. In another control group (N = 210), infants did not use either chlorhexidine or placebo gels. Saliva samples were cultured using S. mutans-selective tryptone-yeast extract-cysteine-sucrose-bacitracin (TYCSB) agar. The mean age of the children was 10.2 +/- 2.6 months at the start of the trial and subjects were followed until the ages of 18 months.In the children with initial low S. mutans counts of < 300 CFU/mL, there was a significant percentage reduction in S. mutans counts in the chlorhexidine-gel group compared to the placebo gel and no-gel control groups after 3 months of weekly gel brushing. However, no significant differences with the placebo group were observed after 15 months of follow-up. There were 39 children (41%) who achieved reduction of their S. mutans to 0 CFU/mL. Compared to those who remained infected with S. mutans, these children had higher toothbrushing frequencies (P < .001) and toothpaste use (P < .001), as well as lower frequencies of daily feeds (P < .01), and lesser weekly frequencies of sweet solids and liquids (P < .001).Children with relatively low initial S. mutans counts (< 300 CFU/mL) showed a reduction in S. mutans counts in the first 3 months when 0.2% chlorhexidine gel was brushed on the teeth weekly. No differences were observed when compared with the placebo and no-treatment groups at later follow-up periods
Melting of Flux Lines in an Alternating Parallel Current
We use a Langevin equation to examine the dynamics and fluctuations of a flux
line (FL) in the presence of an {\it alternating longitudinal current}
. The magnus and dissipative forces are equated to those
resulting from line tension, confinement in a harmonic cage by neighboring FLs,
parallel current, and noise. The resulting mean-square FL fluctuations are
calculated {\it exactly}, and a Lindemann criterion is then used to obtain a
nonequilibrium `phase diagram' as a function of the magnitude and frequency of
. For zero frequency, the melting temperature of the
mixed phase (a lattice, or the putative "Bose" or "Bragg Glass") vanishes at a
limiting current. However, for any finite frequency, there is a non-zero
melting temperature.Comment: 5 pages, 1 figur
Soy intake and breast cancer risk in Singapore Chinese Health Study
We investigated the effects of soy isoflavone intake on breast cancer in a prospective study of 35 303 Singapore Chinese women enrolled during April 1993 to December 1998 in the Singapore Chinese Health Study. At recruitment, each subject was personally administered a validated semiquantitative food frequency questionnaire covering 165 food and beverage items. As of December 31 2005, 629 had developed breast cancer following an accumulation of 338 242 person-years. Using Cox regression and adjusting for age at interview, year of interview, dialect group, education, family history of breast cancer, age when periods became regular, parity, menopausal status, body mass index (BMI), n-3 fatty acid, and other covariates, we found breast cancer risk was reduced significantly in association with high soy intake. Relative to women with lower (below median) soy intake (<10.6 mg isoflavone per 1000 Kcal), women with higher (above median) intake showed a significant 18% risk reduction (relative risk (RR)=0.82, 95% confidence interval (CI)=0.70–0.97). This inverse association was apparent mainly in postmenopausal women (RR=0.74, 95% CI=0.61–0.90), and was not observed in premenopausal women (RR=1.04, 95% CI=0.77–1. 40). Among postmenopausal women, the soy–breast cancer association was stronger in those above median BMI (RR=0.67, 95% CI=0.51–0.88) than in leaner women (RR=0.83, 95% CI=0.62–1.11). Duration of follow-up modified the soy–breast cancer association, the effect being twice as large among women with 10+ vs fewer years of follow-up. Neither oestrogen nor progesterone receptor status of the tumours materially influenced the association. These prospective findings suggest that approximately 10 mg of isoflavones per day, obtained in a standard serving of tofu, may have lasting beneficial effects against breast cancer development
Female trauma patients in the emergency department: should their injury prevention programme be different?
Background: (1) To compare the characteristics of female and male trauma patients seen in the Emergency Department (ED) and (2) to determine if injury prevention programmes for women should be different. Methods: A prospective survey was conducted for 11544 trauma patients, aged 15 years and above, who presented to the ED of an urban public hospital in Singapore over 6 months. The following data were collected: demography, place, type and mechanism of injury and subsequent disposition from the ED. Results: Almost half (49.5%) the injuries sustained by females occurred at home, with low falls of less than 2 metres being the most common mechanism of injury (52.7%). Victims of domestic violence were predominantly female at p<0.0001
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