The rodent research animal holding facility as a barrier to environmental contamination

The rodent Research Animal Holding Facility (RAHF), developed by NASA Ames Research Center (ARC) to separately house rodents in a Spacelab, was verified as a barrier to environmental contaminants during a 12-day biocompatibility test. Environmental contaminants considered were solid particulates, microorganisms, ammonia, and typical animal odors. The 12-day test conducted in August 1988 was designed to verify that the rodent RAHF system would adequately support and maintain animal specimens during normal system operations. Additional objectives of this test were to demonstrate that: (1) the system would capture typical particulate debris produced by the animal; (2) microorganisms would be contained; and (3) the passage of animal odors was adequately controlled. In addition, the amount of carbon dioxide exhausted by the RAHF system was to be quantified. Of primary importance during the test was the demonstration that the RAHF would contain particles greater than 150 micrometers. This was verified after analyzing collection plates placed under exhaust air ducts and rodent cages during cage maintenance operations, e.g., waste tray and feeder changeouts. Microbiological testing identified no additional organisms in the test environment that could be traced to the RAHF. Odor containment was demonstrated to be less than barely detectable. Ammonia could not be detected in the exhaust air from the RAHF system. Carbon dioxide levels were verified to be less than 0.35 percent

Paper Session II-B - Life Sciences Shuttle Flights- 15 Years

Fifteen years ago, the first Life Sciences Announcement of Opportunity offered the promises of man-tended microgravity flights. For the experiments involving nonhuman elements, i.e., plants, animals, tissues and cells, the Shuttle Transportation System (STS) flights posed both challenges and rewards. The transition from the 1-G laboratory bench to O-G environment has resulted in new information with each succeeding flight. These rewards are measured both in better understanding in methods and materials to conduct research within the microgravity milieu and interpretation of the data obtained. The engineering systems developed, operational knowledge gained over the past 15 years, and data base of experimental results being developed, can only enhance, support, and stimulate the scientific community\u27s sights toward NASA\u27s next direction - Space Station Freedom

Dynamic model tracking design for low inertia, high speed permanent magnet ac motors

Permanent magnet a

Coverage-dependent adsorption sites for K/Cu(001) and Cs/Cu(001) determined by surface X-ray diffraction

Surface X-ray diffraction has been used to analyze in situ the room-temperature adsorption behaviour and the structure of K and Cs on Cu(100) at submonolayer coverages. Adsorption of K takes place in fourfold hollow sites up to coverages of about 0.25 monolayers (ML), where 1 ML corresponds to 1.53 × 1015 atoms/cm2. At higher coverages the formation of a quasi-hexagonal incommensurate adlayer is observed. In contrast, for Cs adsorption we observe from the very beginning the formation of the quasi-hexagonal structure up to the completion of the adlayer at about 0.30 ML. For K adsorption in the hollow sites we determine an adsorption height, d = 2.25(15) Å, corresponding to an effective K radius of reff = 1.6(1) Å close to the ionic radius of 1.33 Å. We do not observe a change in the effective radius as a function of coverage. For the quasi-hexagonal Cs structure we find an (average) adsorption height d = 2.94 Å corresponding to an effective radius of reff = 2.18 and 1.93 Å, for the limiting ca hollow- and bridge-site adsorption, respectively. The analysis of the superlattice reflections corresponding to the quasi-hexagonal incommensurate structures indicated that the K adlayer is strongly modulated. The first Fourier component of the substrate-induced modulation was determined to u01 = 1.29(3) Å. In contrast, for Cs/Cu(001) static modulation is much less important (u01 0.2 Å). Variation of the Cs adlayer density by changing the substrate temperature allows continuous expansion and contraction of the adsorbate unit cell. No commensurate-incommensurate transition has been observed

Paper Session I-A - Learning about Life on Space Station

The International Space Station as humanity’s outpost in low Earth orbit, is an ideal platform for studying how to live in space, as well as to conduct research to learn more about life. A long-duration microgravity platform such as ISS allows the study of biological and physiological processes free of the one constant force to which they have been subjected since the origin of life on Earth: gravity. Although construction of ISS is still under way, the US Laboratory Module Destiny has been outfitted with its full complement of 10 research facilities, two of them dedicated to life sciences research. In the coming years, Destiny will be joined by the European Space Agency’s Columbus and by Japan’s Kibo research modules with additional facilities, and then by the Centrifuge Accommodation Module containing a centrifuge for variable gravity research. Research has been ongoing for only 2 of its planned 15 years of orbital life, so we have clearly just opened the door to learning about life on Space Station

Surface PM machine parameter selection for wide field-weakening applications

Recent work on fractional-slot pitch, concentrated winding (FSCW) surface PM machines has shown that these machines can achieve a wide constant-power speed range. This paper shows that defining the allowable machine design parameter plane using the characteristic current and the peak back-emf provides useful insights into how application requirements restrict the machine parameters. The parameter plane also shows the influence of changing the parameters on the machine's current rating and magnet losses. As an example of a practical application, the parameter plane is used to study the FreedomCAR traction motor drive requirements and the characteristics of five FSCW surface PM machine designs.W.L. Soong, P.B. Reddy, A.M. El-Refaie, T.M. Jahns and N. Ertugru

Bacterial Cholangitis, Cholecystitis, or both in Dogs

BACKGROUND: Bacterial cholangitis and cholecystitis are rarely reported, poorly characterized diseases in the dog. OBJECTIVES: To characterize the clinical features of these conditions. ANIMALS: Twenty‐seven client‐owned dogs with bacterial cholangitis, cholecystitis, or both. METHODS: Multicenter, retrospective cases series of dogs with bacterial cholangitis, cholecystitis, or both, presenting January 2000 to June 2011 to 4 Veterinary Schools in Ireland/United Kingdom. Interrogation of hospital databases identified all cases with the inclusion criteria; histopathologically confirmed cholangitis or cholecystitis and bile culture/cytology results supporting a bacterial etiology. RESULTS: Twenty‐seven dogs met the inclusion criteria with approximately 460 hepatitis cases documented over the same study period. Typical clinical pathology findings were increases in liver enzyme activities (25/26), hyperbilirubinemia (20/26), and an inflammatory leukogram (21/24). Ultrasound findings, although nonspecific, aided decision‐making in 25/26 cases. The most frequent hepatobiliary bacterial isolates were Escherichia coli (n = 17; 16 cases), Enterococcus spp. (n = 8; 6 cases), and Clostridium spp. (n = 5; 5 cases). Antimicrobial resistance was an important feature of aerobic isolates; 10/16 E. coli isolates resistant to 3 or more antimicrobial classes. Biliary tract rupture complicated nearly one third of cases, associated with significant mortality (4/8). Discharged dogs had a guarded to fair prognosis; 17/18 alive at 2 months, although 5/10 re‐evaluated had persistent liver enzyme elevation 2–12 months later. CONCLUSION AND CLINICAL SIGNIFICANCE: Bacterial cholangitis and cholecystitis occur more frequently than suggested by current literature and should be considered in dogs presenting with jaundice and fever, abdominal pain, or an inflammatory leukogram or with ultrasonographic evidence of gallbladder abnormalities

Covariance of Antiproton Yield and Source Size in Nuclear Collisions

We confront for the first time the widely-held belief that combined event-by-event information from quark gluon plasma signals can reduce the ambiguity of the individual signals. We illustrate specifically how the measured antiproton yield combined with the information from pion-pion HBT correlations can be used to identify novel event classes.Comment: 8 pages, 5 figures, improved title, references and readability; results unchange