Anisotropy and inflation in Bianchi I brane worlds

After a more general assumption on the influence of the bulk on the brane, we extend some conclusions by Maartens et al. and Santos et al. on the asymptotic behavior of Bianchi I brane worlds. As a consequence of the nonlocal anisotropic stresses induced by the bulk, in most of our models, the brane does not isotropize and the nonlocal energy does not vanish in the limit in which the mean radius goes to infinity. We have also found the intriguing possibility that the inflation due to the cosmological constant might be prevented by the interaction with the bulk. We show that the problem for the mean radius can be completely solved in our models, which include as particular cases those in the references above.Comment: 10 pages, improved discussion on the likeliness of non-isotropization, completed list of references, matches version to appear in Class. Quantum Gra

Hubble Space Telescope Evidence for an Intermediate-Mass Black Hole in the Globular Cluster M15: II. Kinematical Analysis and Dynamical Modeling

We analyze HST/STIS spectra (see Paper I) of the central region of the dense globular cluster M15. We infer the velocities of 64 individual stars, two-thirds of which have their velocity measured for the first time. This triples the number of stars with measured velocities in the central 1 arcsec of M15 and doubles the number in the central 2 arcsec. Combined with existing ground-based data we obtain the radial profiles of the projected kinematical quantities. The RMS velocity sigma_RMS rises to 14 km/s in the central few arcsec, somewhat higher than the values of 10-12 km/s inferred previously from ground-based data. To interpret the results we construct dynamical models based on the Jeans equation, which imply that M15 must have a central concentration of non-luminous material. If this is due to a single black hole, then its mass is M_BH = (3.9 +/- 2.2) x 10^3 solar masses. This is consistent with the relation between M_BH and sigma_RMS that has been established for galaxies. Also, the existence of intermediate-mass black holes in globular clusters is consistent with several scenarios for globular cluster evolution proposed in the literature. Therefore, these results may have important implications for our understanding of the evolution of globular clusters, the growth of black holes, the connection between globular cluster and galaxy formation, and the nature of the recently discovered `ultra-luminous' X-ray sources in nearby galaxies. Instead of a single black hole, M15 could have a central concentration of dark remnants (e.g., neutron stars) due to mass segregation. However, the best-fitting Fokker-Planck models that have previously been constructed for M15 do not predict a central mass concentration that is sufficient to explain the observed kinematics.[ABRIDGED]Comment: 43 pages, LaTeX, with 14 PostScript figures. Astronomical Journal, in press (Dec 2002). Please note that the results reported here are modified by the Addendum available at astro-ph/0210158 (Astronomical Journal, in press, Jan 2003). This second version submitted to astro-ph is identical to first, with the exception of the preceeding remar

3-D Photoionization Structure and Distances of Planetary Nebulae II. Menzel 1

We present the results of a spatio-kinematic study of the planetary nebula Menzel 1 using spectro-photometric mapping and a 3-D photoionization code. We create several 2-D emission line images from our long-slit spectra, and use these to derive the line fluxes for 15 lines, the Halpha/Hbeta extinction map, and the [SII] line ratio density map of the nebula. We use our photoionization code constrained by these data to derive the three-dimensional nebular structure and ionizing star parameters of Menzel 1 by simultaneously fitting the integrated line intensities, the density map, and the observed morphologies in several lines, as well as the velocity structure. Using theoretical evolutionary tracks of intermediate and low mass stars, we derive a mass for the central star of 0.63+-0.05 Msolar. We also derive a distance of 1050+_150 pc to Menzel 1.Comment: To be published in ApJ of 10th February 2005. 12 figure

Subpopulations of bovine WC1+ γδ T cells rather than CD4+CD25highFoxp3+ T cells act as immune regulatory cells ex vivo

Regulatory T cells (Treg) are regarded essential components for maintenance of immune homeostasis. Especially CD4+CD25high T cells are considered to be important regulators of immune reactivity. In humans and rodents these natural Treg are characterized by their anergic nature, defined as a non-proliferative state, suppressive function and expression of Foxp3. In this study the potential functional role of flowcytometry-sorted bovine white blood cell populations, including CD4+CD25high T cells and γδ T cell subpopulations, as distinct ex vivo regulatory cells was assessed in co-culture suppression assays. Our findings revealed that despite the existence of a distinct bovine CD4+CD25high T cell population, which showed Foxp3 transcription/expression, natural regulatory activity did not reside in this cell population. In bovine co-culture suppression assays these cells were neither anergic nor suppressive. Subsequently, the following cell populations were tested functionally for regulatory activity: CD4+CD25low T cells, WC1+, WC1.1+ and WC1.2+ γδ T cells, NK cells, CD8+ T cells and CD14+ monocytes. Only the WC1.1+ and WC1.2+ γδ T cells and CD14+ monocytes proved to act as regulatory cells in cattle, which was supported by the fact that these regulatory cells showed IL-10 transcription/expression. In conclusion, our data provide first evidence that cattle CD4+CD25highFoxp3+ and CD4+CD25low T cells do not function as Treg ex vivo. The bovine Treg function appears to reside in the γδ T cell population, more precisely in the WC1.1+ and the WC1.2+ subpopulation, major populations present in blood of cattle in contrast to non-ruminant species

Quantum Gravity in Large Dimensions

Quantum gravity is investigated in the limit of a large number of space-time dimensions, using as an ultraviolet regularization the simplicial lattice path integral formulation. In the weak field limit the appropriate expansion parameter is determined to be $1/d$. For the case of a simplicial lattice dual to a hypercube, the critical point is found at $k_c/\lambda=1/d$ (with $k=1/8 \pi G$) separating a weak coupling from a strong coupling phase, and with $2 d^2$ degenerate zero modes at $k_c$. The strong coupling, large $G$, phase is then investigated by analyzing the general structure of the strong coupling expansion in the large $d$ limit. Dominant contributions to the curvature correlation functions are described by large closed random polygonal surfaces, for which excluded volume effects can be neglected at large $d$, and whose geometry we argue can be approximated by unconstrained random surfaces in this limit. In large dimensions the gravitational correlation length is then found to behave as $| \log (k_c - k) |^{1/2}$, implying for the universal gravitational critical exponent the value $\nu=0$ at $d=\infty$.Comment: 47 pages, 2 figure

Interventions with potential to reduce sedentary time in adults:Systematic review and meta-analysis

Context: Time spent in sedentary behaviours (SB) is associated with poor health, irrespective of the level of physical activity. The aim of this study was to evaluate the effect of interventions which included SB as an outcome measure in adults. Methods: Thirteen databases, including The Cochrane Library, MEDLINE and SPORTDiscus, trial registers and reference lists, were searched for randomised controlled trials until January 2014. Study selection, data extraction and quality assessment were performed independently. Primary outcomes included SB, proxy measures of SB and patterns of accumulation of SB. Secondary outcomes were cardiometabolic health, mental health and body composition. Intervention types were categorised as SB only, physical activity (PA) only, PA and SB or lifestyle interventions (PA/SB and diet). Results: Of 8087 records, 51 studies met the inclusion criteria. Meta-analysis of 34/51 studies showed a reduction of 22 min/day in sedentary time in favour of the intervention group (95% CI −35 to −9 min/day, n=5868). Lifestyle interventions reduced SB by 24 min/day (95% CI −41 to −8 min/day, n=3981, moderate quality) and interventions focusing on SB only by 42 min/day (95% CI −79 to −5 min/day, n=62, low quality). There was no evidence of an effect of PA and combined PA/SB interventions on reducing sedentary time. Conclusions: There was evidence that it is possible to intervene to reduce SB in adults. Lifestyle and SB only interventions may be promising approaches. More high quality research is needed to determine if SB interventions are sufficient to produce clinically meaningful and sustainable reductions in sedentary time

Increasing Short-Stay Unplanned Hospital Admissions among Children in England; Time Trends Analysis '97-'06

BACKGROUND: Timely care by general practitioners in the community keeps children out of hospital and provides better continuity of care. Yet in the UK, access to primary care has diminished since 2004 when changes in general practitioners' contracts enabled them to 'opt out' of providing out-of-hours care and since then unplanned pediatric hospital admission rates have escalated, particularly through emergency departments. We hypothesised that any increase in isolated short stay admissions for childhood illness might reflect failure to manage these cases in the community over a 10 year period spanning these changes. METHODS AND FINDINGS: We conducted a population based time trends study of major causes of hospital admission in children 2 days. By 2006, 67.3% of all unplanned admissions were isolated short stays <2 days. The increases in admission rates were greater for common non-infectious than infectious causes of admissions. CONCLUSIONS: Short stay unplanned hospital admission rates in young children in England have increased substantially in recent years and are not accounted for by reductions in length of in-hospital stay. The majority are isolated short stay admissions for minor illness episodes that could be better managed by primary care in the community and may be evidence of a failure of primary care services

Dynamical Instabilities of the Randall-Sundrum Model

We derive dynamical equations to describe a single 3-brane containing fluid matter and a scalar field coupling to the dilaton and the gravitational field in a five dimensional bulk. First, we show that a scalar field or an arbitrary fluid on the brane cannot evolve to cancel the cosmological constant in the bulk. Then we show that the Randall-Sundrum model is unstable under small deviations from the fine-tuning between the brane tension and the bulk cosmological constant and even under homogeneous gravitational perturbations. Implications for brane world cosmologies are discussed.Comment: 12 pages, 2 figure

Axisymmetric metrics in arbitrary dimensions

We consider axially symmetric static metrics in arbitrary dimension, both with and without a cosmological constant. The most obvious such solutions have an SO(n) group of Killing vectors representing the axial symmetry, although one can also consider abelian groups which represent a flat `internal space'. We relate such metrics to lower dimensional dilatonic cosmological metrics with a Liouville potential. We also develop a duality relation between vacuum solutions with internal curvature and those with zero internal curvature but a cosmological constant. This duality relation gives a solution generating technique permitting the mapping of different spacetimes. We give a large class of solutions to the vacuum or cosmological constant spacetimes. We comment on the extension of the C-metric to higher dimensions and provide a novel solution for a braneworld black hole.Comment: 36 pages, LaTeX (JHEP), 4 figures, section added (published version