77 research outputs found
Altered cardiac rhythm in infants with bronchiolitis and respiratory syncytial virus infection
Background: Although the most frequent extra-pulmonary manifestations of respiratory syncytial virus (RSV) infection involve the cardiovascular system, no data regarding heart function in infants with bronchiolitis associated with RSV infection have yet been systematically collected. The aim of this study was to verify the real frequency of heart involvement in patients with bronchiolitis associated with RSV infection, and whether infants with mild or moderate disease also risk heart malfunction.Methods: A total of 69 otherwise healthy infants aged 1-12 months with bronchiolitis hospitalised in standard wards were enrolled. Pernasal flocked swabs were performed to collect specimens for the detection of RSV by real-time polymerase chain reaction, and a blood sample was drawn to assess troponin I concentrations. On the day of admission, all of the infants underwent 24-hour Holter ECG monitoring and a complete heart evaluation with echocardiography. Patients were re-evaluated by investigators blinded to the etiological and cardiac findings four weeks after enrolment.Results: Regardless of their clinical presentation, sinoatrial blocks were identified in 26/34 RSV-positive patients (76.5%) and 1/35 RSV-negative patients (2.9%) (p < 0.0001). The blocks recurred more than three times over 24 hours in 25/26 RSV-positive patients (96.2%) and none of the RSV-negative infants. Mean and maximum heart rates were significantly higher in the RSV-positive infants (p < 0.05), as was low-frequency power and the low and high-frequency power ratio (p < 0.05). The blocks were significantly more frequent in the children with an RSV load of 65100,000 copies/mL than in those with a lower viral load (p < 0.0001). Holter ECG after 28 \ub1 3 days showed the complete regression of the heart abnormalities.Conclusions: RSV seems associated with sinoatrial blocks and transient rhythm alterations even when the related respiratory problems are mild or moderate. Further studies are needed to clarify the mechanisms of these rhythm problems and whether they remain asymptomatic and transient even in presence of severe respiratory involvement or chronic underlying disease
Holographic Measurement and Improvement of the Green Bank Telescope Surface
We describe the successful design, implementation, and operation of a 12 GHz
holography system installed on the Robert C. Byrd Green Bank Telescope (GBT).
We have used a geostationary satellite beacon to construct high-resolution
holographic images of the telescope mirror surface irregularities. These images
have allowed us to infer and apply improved position offsets for the 2209
actuators which control the active surface of the primary mirror, thereby
achieving a dramatic reduction in the total surface error (from 390 microns to
~240 microns, rms). We have also performed manual adjustments of the corner
offsets for a few panels. The expected improvement in the radiometric aperture
efficiency has been rigorously modeled and confirmed at 43 GHz and 90 GHz. The
improvement in the telescope beam pattern has also been measured at 11.7 GHz
with greater than 60 dB of dynamic range. Symmetric features in the beam
pattern have emerged which are consistent with a repetitive pattern in the
aperture due to systematic panel distortions. By computing average images for
each tier of panels from the holography images, we confirm that the magnitude
and direction of the panel distortions, in response to the combination of
gravity and thermal gradients, are in general agreement with finite-element
model predictions. The holography system is now fully integrated into the GBT
control system, and by enabling the telescope staff to monitor the health of
the individual actuators, it continues to be an essential tool to support
high-frequency observations.Comment: Accepted for publication in PASP. Contains 28 pages with 2 tables and
9 figures (several at reduced quality). The full resolution version is
available at http://wwwlocal.gb.nrao.edu/ptcs/papers/Hunter2011/gbtholo.ps.gz
(34MB gzip file unpacks to 134MB postscript
"Delirium Day": A nationwide point prevalence study of delirium in older hospitalized patients using an easy standardized diagnostic tool
Background: To date, delirium prevalence in adult acute hospital populations has been estimated generally from pooled findings of single-center studies and/or among specific patient populations. Furthermore, the number of participants in these studies has not exceeded a few hundred. To overcome these limitations, we have determined, in a multicenter study, the prevalence of delirium over a single day among a large population of patients admitted to acute and rehabilitation hospital wards in Italy. Methods: This is a point prevalence study (called "Delirium Day") including 1867 older patients (aged 65 years or more) across 108 acute and 12 rehabilitation wards in Italian hospitals. Delirium was assessed on the same day in all patients using the 4AT, a validated and briefly administered tool which does not require training. We also collected data regarding motoric subtypes of delirium, functional and nutritional status, dementia, comorbidity, medications, feeding tubes, peripheral venous and urinary catheters, and physical restraints. Results: The mean sample age was 82.0 \ub1 7.5 years (58 % female). Overall, 429 patients (22.9 %) had delirium. Hypoactive was the commonest subtype (132/344 patients, 38.5 %), followed by mixed, hyperactive, and nonmotoric delirium. The prevalence was highest in Neurology (28.5 %) and Geriatrics (24.7 %), lowest in Rehabilitation (14.0 %), and intermediate in Orthopedic (20.6 %) and Internal Medicine wards (21.4 %). In a multivariable logistic regression, age (odds ratio [OR] 1.03, 95 % confidence interval [CI] 1.01-1.05), Activities of Daily Living dependence (OR 1.19, 95 % CI 1.12-1.27), dementia (OR 3.25, 95 % CI 2.41-4.38), malnutrition (OR 2.01, 95 % CI 1.29-3.14), and use of antipsychotics (OR 2.03, 95 % CI 1.45-2.82), feeding tubes (OR 2.51, 95 % CI 1.11-5.66), peripheral venous catheters (OR 1.41, 95 % CI 1.06-1.87), urinary catheters (OR 1.73, 95 % CI 1.30-2.29), and physical restraints (OR 1.84, 95 % CI 1.40-2.40) were associated with delirium. Admission to Neurology wards was also associated with delirium (OR 2.00, 95 % CI 1.29-3.14), while admission to other settings was not. Conclusions: Delirium occurred in more than one out of five patients in acute and rehabilitation hospital wards. Prevalence was highest in Neurology and lowest in Rehabilitation divisions. The "Delirium Day" project might become a useful method to assess delirium across hospital settings and a benchmarking platform for future surveys
Retrieval of symmetrical image blur using zero sheets
10.1049/ip-vis:20010143IEE Proceedings: Vision, Image and Signal Processing148165-69IVIP
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