Energy Barrier Enhancement by Ligand Substitution in Tetrairon(III) Single Molecule Magnets

A dramatic increase of the energy barrier (Ueff) in tetrairon(III) single-mol. magnets can be achieved by simple chem. modification. Site-specific replacement of the six methoxide bridges in [Fe4(OMe)6(dpm)6] (Hdpm = dipivaloylmethane; Ueff/kB = 3.5 K) with two tripodal 1,1,1-tris(hydroxymethyl)ethane (H3thme) ligands affords [Fe4(thme)2(dpm)6] with Ueff/kB = 15.6(2) K and a magnetic relaxation time exceeding 1000 s at T <0.2 K. The prepd. complex is trigonal, space group R-3c, Z = 6, R1 = 0.0370, R2 = 0.1089

Idoneit&#224; alla guida dei disabili : l&apos;esperienza del centro di mobilit&#224; di Milano

Idoneit\ue0 alla guida dei disabili : l'esperienza del centro di mobilit\ue0 di Milan

C2-symmetrical sterol–polyether conjugates as highly efficient synthetic ionophores

A new class of artificial ionophores has been rationally designed and synthesized linking to a tetrafunctionalized L-treitol spacer two rigid hydrophobic 3beta-hydroxy-5alpha-23,24-bisnorcholanic units and two flexible hydrophilic oligo(ethylene glycol) chains. Compounds 1a and 1b were incorporated into phospholipid vesicles and shown to facilitate Na+-transport

Experimental test of the collapse time of a delocalized photon state

We investigate whether the collapse of the quantum state of a single photon split between two space- like separated places takes a nonvanishing time. We realize this by using a source of heralded single photons, then splitting the resulting single photon state and letting it propagate over distances much larger than the experimental time resolution times the speed of light c. We find no additional delay within our accuracy and set a lower limit for the speed of collapse of the quantum state to 1550c

Body mass index and serum proteomic profile in breast cancer and healthy women: a prospective study.

Epidemiological studies suggest a possible association between BMI, diagnosis and clinical-pathological breast cancer characteristics but biological bases for this relationship still remain to be ascertained. Several biological mechanisms play a role in the genesis and progression of breast cancer. This study aimed to investigate relationships between BMI and breast cancer diagnosis/progression in a Southern Italian population and to try to interpret results according to the serum proteomic profile of healthy and breast cancer patients. BMI, presence or absence of breast cancer and its clinical-pathological characteristics were analyzed in a series of 300 breast cancer women and compared with those of 300 healthy women prospectively. To investigate whether obesity is associated with alterations in serum protein profile, SELDI-ToF approach was applied.Alcohol consumption (22.7% vs 11.3%; p = 30 respect to normal weight: OR = 2.49, 95% CI 1.25-4.99, p = 0.0098) and a higher probability of having positive axillary lymph node (OR = 3.67, CI 95% 2.16-6.23, p<0.0001). Multivariate analysis confirmed the association of breast cancer diagnosis with alcohol consumption (OR = 2.28;CI 1.36-3.83; p<0.0018). Serum protein profile revealed the presence of significant (p-value <0,01) differentially expressed peaks m/z 6934, m/z 5066 in high BMI breast cancer patients vs healthy subjects and m/z 6934, m/z 3346 in high vs low BMI breast cancer patients.The analysis of pathological features of cancer indicates that normal weight women have a significantly higher probability of having a smaller breast cancer at time of diagnosis and negative axillary lymph nodes while increased BMI is associated with an altered protein profile in breast cancer patients. Further studies to identify specific proteins found in the serum and their role in breast cancerogenesis and progression are in progress

An artificial ionophore based on a polyhydroxylated steroid dimer

The Na+ transporting properties of the first member of a new class of artificial ionophores, based on a C-2-symmetric polyhydroxylated steroid dimer, are described

Tuneable Energy Barriers in Tetrairon(III) Single–molecule Magnets

The tetrairon(III) clusters Fe4(L)2(dpm)6 where Hdpm = dipivaloylmethane and H3L = MeC(CH2OH)3 or PhC(CH2OH)3 were obtained by site-specific replacement of the six methoxide bridges in Fe4(OMe)6(dpm)6. As compared with the parent compd., the new clusters show a much larger anisotropy in the S = 5 ground spin state (D/kB∼-0.6 K vs. -0.3 K) and a higher energy barrier to the reversal of the magnetization

An artificial ionophore based on a polyhydroxylated steroid dimer

8The Na+ transporting properties of the first member of a new class of artificial ionophores, based on a C-2-symmetric polyhydroxylated steroid dimer, are described.nonenoneDI FILIPPO M.; GARRISI D.; IZZO I.; MANCIN F.; PASQUATO L.; DE RICCARDIS F.; SCRIMIN P.; TECILLA P.DI FILIPPO, M.; Garrisi, D.; Izzo, I.; Mancin, F.; Pasquato, Lucia; DE RICCARDIS, F.; Scrimin, P.; Tecilla, Paol