Pharmacological correction of immune disorders in patients with chronic heart failure and ischemic heart disease

Currently, there are few data on the effect of cardiovascular drugs on the immune status of patients with heart failure (HF). This paper provides information on the impact of ß-adrenergic blocking agent (BAB), angiotensin-converting enzyme inhibitors (ACEI) on the maintenance of markers of immune inflammation in the blood, as well as on inhibition of synthesis of tumor necrosis factor-α (TNF-α) and on blocking of interaction between TNF-α and membrane receptor

Splitting technique for analytical modelling of two-phase multicomponent flow in porous media

In this paper we discuss one-dimensional models for two-phase Enhanced Oil Recovery (EOR) floods (oil displacement by gases, polymers, carbonized water, hot water, etc.). The main result presented here is the splitting of the EOR mathematical model into thermodynamical and hydrodynamical parts. The introduction of a potential associated with one of the conservation laws and its use as a new independent coordinate reduces the number of equations by one. The (n) × (n) conservation law model for two-phase n-component EOR flows in new coordinates is transformed into a reduced (n − 1) × (n − 1) auxiliary system containing just thermodynamical variables (equilibrium fractions of components, sorption isotherms) and one lifting equation containing just hydrodynamical parameters (phase relative permeabilities and viscosities). The algorithm to solve analytically the problem includes solution of the reduced auxiliary problem, solution of one lifting hyperbolic equation and inversion of the coordinate transformation. The splitting allows proving the independence of phase transitions occurring during displacement of phase relative permeabilities and viscosities. For example, the minimum miscibility pressure (MMP) and transitional tie lines are independent of relative permeabilities and phases viscosities. Relative motion of polymer, surfactant and fresh water slugs depends on sorption isotherms only. Therefore, MMP for gasflood or minimum fresh water slug size providing isolation of polymer/surfactant from incompatible formation water for chemical flooding can be calculated from the reduced auxiliary system. Reduction of the number of equations allows the generation of new analytical models for EOR. The analytical model for displacement of oil by a polymer slug with water drive is presented.Adolfo P. Pires, Pavel G. Bedrikovetsky, Alexander A. Shapir

Periodic Pattern in the Residual-Velocity Field of OB Associations

An analysis of the residual-velocity field of OB associations within 3 kpc of the Sun has revealed periodic variations in the radial residual velocities along the Galactic radius vector with a typical scale length of lambda=2.0(+/-0.2) kpc and a mean amplitude of fR=7(+/-1) km/s. The fact that the radial residual velocities of almost all OB-associations in rich stellar-gas complexes are directed toward the Galactic center suggests that the solar neighborhood under consideration is within the corotation radius. The azimuthal-velocity field exhibits a distinct periodic pattern in the region 0<l<180 degrees, where the mean azimuthal-velocity amplitude is ft=6(+/-2) km/s. There is no periodic pattern of the azimuthal-velocity field in the region 180<l<360 degrees. The locations of the Cygnus arm, as well as the Perseus arm, inferred from an analysis of the radial- and azimuthal-velocity fields coincide. The periodic patterns of the residual-velocity fields of Cepheids and OB associations share many common features.Comment: 21 page

Open Clusters IC 4665 and Cr 359 and a Probable Birthplace of the Pulsar PSR B1929+10

Based on the epicyclic approximation, we have simulated the motion of the young open star clusters IC 4665 and Collinder 359. The separation between the cluster centers is shown to have been minimal 7 Myr ago, 36 pc. We have established a close evolutionary connection between IC 4665 and the Scorpius-Centaurus association -- the separation between the centers of these structures was $\approx200$ pc 15 Myr ago. In addition, the center of IC 4665 at this time was near two well-known regions of coronal gas: the Local Bubble and the North Polar Spur. The star HIP 86768 is shown to be one of the candidates for a binary (in the past) with the pulsar PSR B1929+10. At the model radial velocity of the pulsar $V_r= 2\pm50$ km s$^{-1}$, a close encounter of this pair occurs in the vicinity of IC 4665 at a time of -1.1 Myr. At the same time, using currently available data for the pulsar B1929+10 at its model radial velocity $V_r=200\pm50$ km s$^{-1}$, we show that the hypothesis of Hoogerwerf et al. (2001) about the breakup of the $\zeta$Oph--B1929+10 binary in the vicinity of Upper Scorpius (US) about 0.9 Myr ago is more plausible.Comment: 19 pages, 8 figure

Kinematic Control of the Inertiality of ICRS Catalogs

We perform a kinematic analysis of the Hipparcos and TRC proper motions of stars by using a linear Ogorodnikov-Milne model. All of the distant (r more than 0.2 kpc) stars of the Hipparcos catalog have been found to rotate around the Galactic y axis with an angular velocity of -0.36 +/- 0.09 mas/year. One of the causes of this rotation may be an uncertainty in the lunisolar precession constant adopted when constructing the ICRS. In this case? the correction to the IAU (1976) lunisolar precession constant in longitude is shown to be -3.26 +/- 0.10 mas/yr. Based on the TRC catalog, we have determined the main Oort constants: A = 14.9 +/- 1.0 and B = -10.8 +/- 0.3 km/s/kpc. The component of the model that describes the rotation of all TRC stars around the Galactic y axis is nonzero for all magnitudes, My= -0.86 +/- 0.11 mas/yr.Comment: 10 pages, 4 figures, 2 table

Dynamics of Gaseous Disks in a Non-axisymmetric Dark Halo

The dynamics of a galactic disk in a non-axisymmetric (triaxial) dark halo is studied in detail using high-resolution, numerical, hydrodynamical models. A long-lived, two-armed spiral pattern is generated for a wide range of parameters. The spiral structure is global, and the number of turns can be two or three, depending on the model parameters. The morphology and kinematics of the spiral pattern are studied as functions of the halo and disk parameters. The spiral structure rotates slowly, and its angular velocity varies quasi-periodically. Models with differing relative halo masses, halo semi-axis ratios, distributions of matter in the disk, Mach numbers in the gaseous component, and angular rotational velocities of their halos are considered.Comment: 22 pages, 11 figure

Kinematic Peculiarities of Gould Belt Stars

We analyzed the space velocities of Gould Belt stars younger than 125 Myr located at heliocentric distances <650 pc. We determined the rotation and expansion parameters of the Gould Belt by assuming the existence of a single kinematic center whose direction was found to be the following: $l_\circ=128^\circ$ and $R_\circ=150$ pc. The linear velocities reach their maximum at a distance of $\approx300$ pc from the center and are -6 km s$^{-1}$ for the rotation (whose direction coincides with the Galactic rotation) and +4 km s$^{-1}$ for the expansion. The stellar rotation model used here is shown to give a more faithful description of the observed velocity field than the linear model based on the Oort constants $A_G$ and $B_G$. We present evidence that the young clusters $\beta$ Pic, Tuc/HorA, and TWA belong to the Gould Belt structure.Comment: 17 pages, 5 figure

Pharmacological correction of immune disorders in patients with chronic heart failure and ischemic heart disease

Currently, there are few data on the effect of cardiovascular drugs on the immune status of patients with heart failure (HF). This paper provides information on the impact of ß-adrenergic blocking agent (BAB), angiotensin-converting enzyme inhibitors (ACEI) on the maintenance of markers of immune inflammation in the blood, as well as on inhibition of synthesis of tumor necrosis factor-α (TNF-α) and on blocking of interaction between TNF-α and membrane receptor